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  1. Artikel ; Online: Capsaicin-sensitive cutaneous primary afferents convey electrically induced itch in humans.

    Andersen, Hjalte H / van Laarhoven, Antoinette I M / Justesen, Frederik D / Pedersen, Jacob B / Sørensen, Laurits L / Jensen, Line P / Arendt-Nielsen, Lars

    Neuroscience letters

    2018  Band 666, Seite(n) 186–189

    Abstract: Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated ... ...

    Abstract Specially designed transcutaneous electrical stimulation paradigms can be used to provoke experimental itch. However, it is unclear which primary afferent fibers are activated and whether they represent pathophysiologically relevant, C-fiber mediated itch. Since low-threshold mechano-receptors have recently been implicated in pruriception we aimed to characterize the peripheral primary afferent subpopulation conveying electrically evoked itch in humans (50Hz stimulation, 100μs square pulses, stimulus-response function to graded stimulus intensity). In 10 healthy male volunteers a placebo-controlled, 24-h 8% topical capsaicin-induced defunctionalization of capsaicin-sensitive (transient receptor potential V1-positive, 'TRPV1'
    Mesh-Begriff(e) Administration, Cutaneous ; Adult ; Capsaicin/pharmacology ; Electric Stimulation/methods ; Histamine/pharmacology ; Humans ; Male ; Nociceptors/physiology ; Pain Threshold/drug effects ; Pruritus/chemically induced ; Skin/physiopathology ; Young Adult
    Chemische Substanzen Histamine (820484N8I3) ; Capsaicin (S07O44R1ZM)
    Sprache Englisch
    Erscheinungsdatum 2018-02-08
    Erscheinungsland Ireland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 194929-9
    ISSN 1872-7972 ; 0304-3940
    ISSN (online) 1872-7972
    ISSN 0304-3940
    DOI 10.1016/j.neulet.2017.11.061
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: NMDAR activation regulates the daily rhythms of sleep and mood.

    Burgdorf, Jeffrey S / Vitaterna, Martha H / Olker, Christopher J / Song, Eun Joo / Christian, Edward P / Sørensen, Laurits / Turek, Fred W / Madsen, Torsten M / Khan, M Amin / Kroes, Roger A / Moskal, Joseph R

    Sleep

    2019  Band 42, Heft 10

    Abstract: Study objectives: The present studies examine the effects of NMDAR activation by NYX-2925 diurnal rhythmicity of both sleep and wake as well as emotion.: Methods: Twenty-four-hour sleep EEG recordings were obtained in sleep-deprived and non-sleep- ... ...

    Abstract Study objectives: The present studies examine the effects of NMDAR activation by NYX-2925 diurnal rhythmicity of both sleep and wake as well as emotion.
    Methods: Twenty-four-hour sleep EEG recordings were obtained in sleep-deprived and non-sleep-deprived rats. In addition, the day-night cycle of both activity and mood was measured using home cage ultrasonic-vocalization recordings.
    Results: NYX-2925 significantly facilitated non-REM (NREM) sleep during the lights-on (sleep) period, and this effect persisted for 3 days following a single dose in sleep-deprived rats. Sleep-bout duration and REM latencies were increased without affecting total REM sleep, suggesting better sleep quality. In addition, delta power during wake was decreased, suggesting less drowsiness. NYX-2925 also rescued learning and memory deficits induced by sleep deprivation, measured using an NMDAR-dependent learning task. Additionally, NYX-2925 increased positive affect and decreased negative affect, primarily by facilitating the transitions from sleep to rough-and-tumble play and back to sleep. In contrast to NYX-2925, the NMDAR antagonist ketamine acutely (1-4 hours post-dosing) suppressed REM and non-REM sleep, increased delta power during wake, and blunted the amplitude of the sleep-wake activity rhythm.
    Discussion: These data suggest that NYX-2925 could enhance behavioral plasticity via improved sleep quality as well as vigilance during wake. As such, the facilitation of sleep by NYX-2925 has the potential to both reduce symptom burden on neurological and psychiatric disorders as well as serve as a biomarker for drug effects through restoration of sleep architecture.
    Mesh-Begriff(e) Affect/drug effects ; Affect/physiology ; Animals ; Circadian Rhythm/drug effects ; Circadian Rhythm/physiology ; Electroencephalography/methods ; Male ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate/agonists ; Receptors, N-Methyl-D-Aspartate/physiology ; Sleep/drug effects ; Sleep/physiology ; Sleep Deprivation/drug therapy ; Sleep Deprivation/physiopathology ; Spiro Compounds/pharmacology ; Spiro Compounds/therapeutic use ; Wakefulness/drug effects ; Wakefulness/physiology
    Chemische Substanzen NYX-2925 ; Receptors, N-Methyl-D-Aspartate ; Spiro Compounds
    Sprache Englisch
    Erscheinungsdatum 2019-09-10
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 424441-2
    ISSN 1550-9109 ; 0161-8105
    ISSN (online) 1550-9109
    ISSN 0161-8105
    DOI 10.1093/sleep/zsz135
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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