Article ; Online: Photopic negative response using a handheld mini-ganzfeld stimulator in healthy adults: normative values, intra- and inter-session variability.
Documenta ophthalmologica. Advances in ophthalmology
2020 Volume 142, Issue 2, Page(s) 153–163
Abstract: Purpose: To determine normative values, intra- and inter-session variability for a range of parameters derived from the photopic negative response (PhNR) using a handheld mini-Ganzfeld stimulator in healthy normal adults.: Methods: Light-adapted ... ...
Abstract | Purpose: To determine normative values, intra- and inter-session variability for a range of parameters derived from the photopic negative response (PhNR) using a handheld mini-Ganzfeld stimulator in healthy normal adults. Methods: Light-adapted flash full-field electroretinograms (ERGs) were recorded from healthy individuals with no visual complaints, visual acuity equal to or better than 0.0 logMAR (20/20 Snellen), and negative family history for visual diseases. ERGs were recorded from both eyes using a DTL Results: Normative limits for PhNR amplitude (µV) using 1, 5 and 7 cd.s./m2 stimuli were, respectively: 20.81; 18.06 and 19.60 for BT and 69.11; 77.98; 76.51 for PT. Peak times (ms) normative limits for 1, 5 and 7 cd.s/m2 intensities were, respectively, 65.98; 78.20 and 77.96. Overall, intra-session variability assessed by coefficients of variation ranged from 1.35 to 10.28%. Inter-session variability disclosed significant intraclass correlation values for all PhNR parameters only for 1 cd.s/m2 stimuli. Conclusions: The normative values provided by this study are clinically helpful in the diagnosis of inner retinal disorders, especially those affecting retinal ganglion cells such as glaucoma and other optic neuropathies. Further studies, including a larger sample with variable age range would extend the validity of the current results. |
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MeSH term(s) | Adolescent ; Adult ; Color Vision/physiology ; Electroretinography/methods ; Female ; Healthy Volunteers ; Humans ; Male ; Microelectrodes ; Middle Aged ; Observer Variation ; Photic Stimulation ; Reference Values ; Retina/physiology ; Retinal Ganglion Cells/physiology ; Young Adult |
Language | English |
Publishing date | 2020-07-17 |
Publishing country | Netherlands |
Document type | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 212594-8 |
ISSN | 1573-2622 ; 0012-4486 |
ISSN (online) | 1573-2622 |
ISSN | 0012-4486 |
DOI | 10.1007/s10633-020-09784-x |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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