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  1. Artikel ; Online: Chromatin dynamics and subnuclear gene positioning for transcriptional regulation.

    Sakamoto, Takuya / Matsunaga, Sachihiro

    Current opinion in plant biology

    2023  Band 75, Seite(n) 102431

    Abstract: Plants have been found to exhibit diverse characteristics and functions of chromatin organization, showing both similarities and differences to animals. It is becoming clear how chromatin organization is linked to transcriptional regulation in response ... ...

    Abstract Plants have been found to exhibit diverse characteristics and functions of chromatin organization, showing both similarities and differences to animals. It is becoming clear how chromatin organization is linked to transcriptional regulation in response to environmental stresses. Regulation of specific chromatin positions in the nuclear space is important for transcription, and the mechanisms that enable such chromatin dynamics are gradually being unveiled. Genes move between subdomains responsible for transcriptional activation or suppression in the subnuclear space in a gene repositioning cycle. We propose a model of localized chromatin interaction in nuclear subdomains, in which the dynamics of local chromatin interactions have a more important impact on the regulation of gene expression than large-scale chromatin organization. In this mini-review, we highlight recent findings on chromatin dynamics, particularly involving transcriptional regulation, and discuss future directions in the study of chromatin organization in plants.
    Mesh-Begriff(e) Animals ; Chromatin/genetics ; Gene Expression Regulation
    Chemische Substanzen Chromatin
    Sprache Englisch
    Erscheinungsdatum 2023-08-08
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2023.102431
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  2. Buch ; Online: Stepped-frequency DORT Imaging with Singular Value Decomposition for a Single-antenna Ultrawideband Radar in Multi-path Environments

    Sakamoto, Takuya

    2021  

    Abstract: Ultrawideband radar is an attractive technology for a variety of applications including security systems. As such, it is essential to develop low-cost systems that produce clear target images. Electromagnetic inverse scattering with time-reversal imaging ...

    Abstract Ultrawideband radar is an attractive technology for a variety of applications including security systems. As such, it is essential to develop low-cost systems that produce clear target images. Electromagnetic inverse scattering with time-reversal imaging has been studied for a variety of applications. The time-reversal method, however, uses large-scale antenna arrays, making the system potentially more costly. In this study, we propose an ultrawideband radar imaging algorithm, namely the stepped-frequency DORT algorithm, that uses multi-path scattering for a single antenna. The proposed imaging method is an extension of the conventional DORT method, and uses a frequency-frequency matrix that is suitable for a system with a single antenna. The performance of the proposed method is verified through numerical simulations.

    Comment: 7 pages, 10 figures
    Schlagwörter Electrical Engineering and Systems Science - Signal Processing
    Thema/Rubrik (Code) 518
    Erscheinungsdatum 2021-10-13
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Chromatin dynamics and subnuclear gene positioning for transcriptional regulation

    Sakamoto, Takuya / Matsunaga, Sachihiro

    Current Opinion in Plant Biology. 2023 Oct., v. 75 p.102431-

    2023  

    Abstract: Plants have been found to exhibit diverse characteristics and functions of chromatin organization, showing both similarities and differences to animals. It is becoming clear how chromatin organization is linked to transcriptional regulation in response ... ...

    Abstract Plants have been found to exhibit diverse characteristics and functions of chromatin organization, showing both similarities and differences to animals. It is becoming clear how chromatin organization is linked to transcriptional regulation in response to environmental stresses. Regulation of specific chromatin positions in the nuclear space is important for transcription, and the mechanisms that enable such chromatin dynamics are gradually being unveiled. Genes move between subdomains responsible for transcriptional activation or suppression in the subnuclear space in a gene repositioning cycle. We propose a model of localized chromatin interaction in nuclear subdomains, in which the dynamics of local chromatin interactions have a more important impact on the regulation of gene expression than large-scale chromatin organization. In this mini-review, we highlight recent findings on chromatin dynamics, particularly involving transcriptional regulation, and discuss future directions in the study of chromatin organization in plants.
    Schlagwörter chromatin ; genes ; models ; plant biology ; transcription (genetics) ; transcriptional activation ; Chromatin organization ; Centromeres ; Lamina ; Gene positioning ; Super-enhancer
    Sprache Englisch
    Erscheinungsverlauf 2023-10
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel ; Online
    ZDB-ID 1418472-2
    ISSN 1879-0356 ; 1369-5266
    ISSN (online) 1879-0356
    ISSN 1369-5266
    DOI 10.1016/j.pbi.2023.102431
    Datenquelle NAL Katalog (AGRICOLA)

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  4. Artikel ; Online: First noncontact millimeter-wave radar measurement of heart rate in great apes: Validation in chimpanzees (Pan troglodytes).

    Matsumoto, Takuya / Iwata, Itsuki / Sakamoto, Takuya / Hirata, Satoshi

    American journal of primatology

    2024  , Seite(n) e23633

    Abstract: Heart rate is a crucial vital sign and a valuable indicator for assessing the physical and psychological condition of a target animal. Heart rate contributes to (1) fundamental information for cognitive research, (2) an indicator of psychological and ... ...

    Abstract Heart rate is a crucial vital sign and a valuable indicator for assessing the physical and psychological condition of a target animal. Heart rate contributes to (1) fundamental information for cognitive research, (2) an indicator of psychological and physical stress, and (3) improving the animal welfare of captive animals, especially in nonhuman primate studies. Heart rate has been measured using a contact-type device; however, the device burdens the target animals and that there are risks associated with anesthesia during installation. This study explores the application of heartbeat measurement techniques using millimeter-wave radar, primarily developed for humans, as a remote and noninvasive method for measuring the heart rate of nonhuman primates. Through a measurement test conducted on two chimpanzees, we observed a remarkable correspondence between the peak frequency spectrum of heart rate estimated using millimeter-wave radar and the mean value obtained from electrocardiograph data, thereby validating the accuracy of the method. To the best of our knowledge, this is the first demonstration of the precise measurement of great apes' heart rate using millimeter-wave radar technology. Compared to heart rate measurement using video analysis, the method using millimeter-wave radar has the advantage that it is less susceptible to weather and lighting conditions and that measurement techniques for multiple individuals have been developed for human subjects, while its disadvantage is that validation of measurement from long distances has not been completed. Another disadvantage common to both methods is that measurement becomes difficult when the movement of the target individual is large. The possibility of noncontact measurement of heart rate in wild and captive primates will undoubtedly open up a new research area while taking animal welfare into consideration.
    Sprache Englisch
    Erscheinungsdatum 2024-05-22
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1495834-X
    ISSN 1098-2345 ; 0275-2565
    ISSN (online) 1098-2345
    ISSN 0275-2565
    DOI 10.1002/ajp.23633
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Online: Signal Separation Using a Mathematical Model of Physiological Signals for the Measurement of Heart Pulse Wave Propagation With Array Radar

    Sakamoto, Takuya

    2020  

    Abstract: The arterial pulse wave, which propagates along the artery, is an important indicator of various cardiovascular diseases. By measuring the displacement at multiple parts of the human body, pulse wave velocity can be estimated from the pulse transit time. ...

    Abstract The arterial pulse wave, which propagates along the artery, is an important indicator of various cardiovascular diseases. By measuring the displacement at multiple parts of the human body, pulse wave velocity can be estimated from the pulse transit time. This paper proposes a technique for signal separation using an antenna array, so that pulse wave propagation can be measured in a non-contact manner. The body displacements due to the pulse wave at different body parts are highly correlated, and cannot be accurately separated using techniques that assume independent or uncorrelated signals. The proposed method formulates the signal separation as an optimization problem, based on a mathematical model of the arterial pulse wave. The objective function in the optimization comprises four terms that are derived based on a small-displacement approximation, unimodal impulse response approximation, and a causality condition. The optimization process was implemented using a genetic algorithm. The effectiveness of the proposed method is demonstrated through numerical simulations and experiments.

    Comment: This paper has been published in IEEE Access (Early Access), 12 pages, 17 figures
    Schlagwörter Electrical Engineering and Systems Science - Signal Processing
    Thema/Rubrik (Code) 530
    Erscheinungsdatum 2020-08-20
    Erscheinungsland us
    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  6. Buch ; Online: Ultra-Wideband Radar and Wireless Human Sensing

    Sakamoto, Takuya

    2020  

    Abstract: This study presents the progress of our recent research regarding wireless measurements of the human body. First, we explain radar imaging algorithms for screening passengers at security checkpoints that can process data faster than existing algorithms ... ...

    Abstract This study presents the progress of our recent research regarding wireless measurements of the human body. First, we explain radar imaging algorithms for screening passengers at security checkpoints that can process data faster than existing algorithms to generate accurate and high-resolution images of human bodies. Second, we introduce signal processing techniques for accurately measuring radar micro-Doppler signals associated with human motions and activities. Finally, we present radar signal processing algorithms for measuring human respiration, heartbeat, and other types of motion. Such algorithms can be applied in various fields including healthcare, security, biometric identification, and man-machine interfaces. These fields have one thing in common: prior knowledge about the human shape, motion, and physiology are effectively exploited to improve performance by optimizing the radar systems and signal processing algorithms.

    Comment: 9 pages and 13 figures
    Schlagwörter Electrical Engineering and Systems Science - Signal Processing
    Thema/Rubrik (Code) 006
    Erscheinungsdatum 2020-12-03
    Erscheinungsland us
    Dokumenttyp Buch ; Online
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  7. Buch ; Online: Personal Identification Using Ultrawideband Radar Measurement of Walking and Sitting Motions and a Convolutional Neural Network

    Sakamoto, Takuya

    2020  

    Abstract: This study proposes a personal identification technique that applies machine learning with a two-layered convolutional neural network to spectrogram images obtained from radar echoes of a target person in motion. The walking and sitting motions of six ... ...

    Abstract This study proposes a personal identification technique that applies machine learning with a two-layered convolutional neural network to spectrogram images obtained from radar echoes of a target person in motion. The walking and sitting motions of six participants were measured using an ultrawideband radar system. Time-frequency analysis was applied to the radar signal to generate spectrogram images containing the micro-Doppler components associated with limb movements. A convolutional neural network was trained using the spectrogram images with personal labels to achieve radar-based personal identification. The personal identification accuracies were evaluated experimentally to demonstrate the effectiveness of the proposed technique.

    Comment: 9 pages, 7 figures, and 3 tables
    Schlagwörter Electrical Engineering and Systems Science - Signal Processing
    Erscheinungsdatum 2020-08-05
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    Dokumenttyp Buch ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  8. Artikel ; Online: Novel whole-mount FISH analysis for intact root of Arabidopsis thaliana with spatial reference to 3D visualization.

    Kikuchi, Suzuka / Sakamoto, Takuya / Matsunaga, Sachihiro / Iwamoto, Akitoshi

    Journal of plant research

    2023  Band 136, Heft 3, Seite(n) 423–428

    Abstract: Whole-mount fluorescent in situ hybridization (WM-FISH) is an effective tool to observe chromosome behavior in tissues or organs. However, it is difficult to obtain a precise spatial profile of fluorescent signals in roots using conventional WM-FISH ... ...

    Abstract Whole-mount fluorescent in situ hybridization (WM-FISH) is an effective tool to observe chromosome behavior in tissues or organs. However, it is difficult to obtain a precise spatial profile of fluorescent signals in roots using conventional WM-FISH mainly because of the severe damage caused during the processing. To address this problem, we established a novel WM-FISH analysis for intact roots of Arabidopsis thaliana and successfully obtained a precise spatial profile of nuclear size and centromere signals. The two main improvements in the novel WM-FISH analysis are: (i) hybridization was performed directly on MAS-coated glass slides covered with silicon wells and (ii) conditions for enzyme treatment were optimized (37 °C, 45 s). After the WM-FISH using a centromere probe, we analyzed the results by 3D data processing to quantify the nuclear volume and number of centromere signals of the obtained cortical cell files and determined the position of each nucleus in intact roots. Then we plotted the nuclear volume and number of centromere signals versus distance from the quiescent center to evaluate the precise spatial profile of each parameter.
    Mesh-Begriff(e) Arabidopsis/genetics ; In Situ Hybridization, Fluorescence/methods ; Imaging, Three-Dimensional/methods ; Cell Nucleus/genetics
    Sprache Englisch
    Erscheinungsdatum 2023-01-31
    Erscheinungsland Japan
    Dokumenttyp Journal Article
    ZDB-ID 2077362-6
    ISSN 1618-0860 ; 0918-9440
    ISSN (online) 1618-0860
    ISSN 0918-9440
    DOI 10.1007/s10265-023-01438-8
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  9. Artikel ; Online: Nuclear pore complex proteins are involved in centromere distribution.

    Ito, Nanami / Sakamoto, Takuya / Oko, Yuka / Sato, Hikaru / Hanamata, Shigeru / Sakamoto, Yuki / Matsunaga, Sachihiro

    iScience

    2024  Band 27, Heft 2, Seite(n) 108855

    Abstract: The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker of nucleoskeleton and cytoskeleton (LINC) complex. However, other nuclear membrane structures and nuclear proteins are probably involved in centromere ... ...

    Abstract The subnuclear distribution of centromeres is cooperatively regulated by condensin II and the linker of nucleoskeleton and cytoskeleton (LINC) complex. However, other nuclear membrane structures and nuclear proteins are probably involved in centromere dynamics and distribution. Here, we focused on the nuclear pore complex (NPC), which is known to regulate gene expression, transcription memory, and chromatin structure in addition to transport between the cytoplasm and nucleoplasm. We report here that some nucleoporins (Nups), including Nup85, Nup133, CG1, Nup93b, and NUA, are involved in centromere scattering in
    Sprache Englisch
    Erscheinungsdatum 2024-01-11
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.108855
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  10. Artikel: Antecedents and Outcomes of Work Engagement among Psychiatric Nurses in Japan.

    Kato, Yuichi / Chiba, Rie / Shimazu, Akihito / Hayashi, Yuta / Sakamoto, Takuya

    Healthcare (Basel, Switzerland)

    2023  Band 11, Heft 3

    Abstract: While previous studies have examined antecedents and outcomes of work engagement among general nurses, studies among psychiatric nurses remain limited. This study aimed to explore the antecedents (i.e., job crafting and nursing practice environment) and ... ...

    Abstract While previous studies have examined antecedents and outcomes of work engagement among general nurses, studies among psychiatric nurses remain limited. This study aimed to explore the antecedents (i.e., job crafting and nursing practice environment) and outcomes (i.e., strength-oriented care attitudes, mental health, and turnover intention) of work engagement among psychiatric nurses in Japan. This cross-sectional study included 309 nurses from three psychiatric hospitals in Japan (valid response rate: 60.4%). Data collection using the self-administered questionnaire took place from July to August 2021. We performed Structural Equation Modeling to examine the directional relationships among variables. Job crafting (β = 0.57,
    Sprache Englisch
    Erscheinungsdatum 2023-01-18
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2721009-1
    ISSN 2227-9032
    ISSN 2227-9032
    DOI 10.3390/healthcare11030295
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