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  1. Artikel ; Online: MicroCLOTS pathophysiology in coronavirus disease 2019

    Samuele Renzi / Giovanni Landoni / Alberto Zangrillo / Fabio Ciceri

    The Korean Journal of Internal Medicine, Vol 38, Iss 4, Pp 570-

    2023  Band 571

    Schlagwörter Medicine ; R
    Sprache Englisch
    Erscheinungsdatum 2023-07-01T00:00:00Z
    Verlag The Korean Association of Internal Medicine
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: Splenic rupture or infarction associated with Epstein-Barr virus infectious mononucleosis

    Johannes M. A. Toti / Beatrice Gatti / Isabella Hunjan / Lisa Kottanattu / Pietro B. Faré / Samuele Renzi / Mario G. Bianchetti / Gregorio P. Milani / Sebastiano A. G. Lava / Pietro Camozzi

    Swiss Medical Weekly, Vol 153, Iss

    a systematic literature review

    2023  Band 5

    Abstract: BACKGROUND: Epstein-Barr virus (EBV), also known as human herpesvirus 4, is one of the most common pathogenic viruses in humans. EBV mononucleosis always involves the spleen and as such it predisposes to splenic rupture, often without a trauma, and ... ...

    Abstract BACKGROUND: Epstein-Barr virus (EBV), also known as human herpesvirus 4, is one of the most common pathogenic viruses in humans. EBV mononucleosis always involves the spleen and as such it predisposes to splenic rupture, often without a trauma, and splenic infarction. Nowadays the goal of management is to preserve the spleen, thereby eliminating the risk of post-splenectomy infections. METHODS: To characterise these complications and their management, we performed a systematic review (PROSPERO CRD42022370268) following PRISMA guidelines in three databases: Excerpta Medica, the United States National Library of Medicine, and Web of Science. Articles listed in Google Scholar were also considered. Eligible articles were those describing splenic rupture or infarction in subjects with Epstein-Barr virus mononucleosis. RESULTS: In the literature, we found 171 articles published since 1970, documenting 186 cases with splenic rupture and 29 with infarction. Both conditions predominantly occurred in males, 60% and 70% respectively. Splenic rupture was preceded by a trauma in 17 (9.1%) cases. Approximately 80% (n = 139) of cases occurred within three weeks of the onset of mononucleosis symptoms. A correlation was found between the World Society of Emergency Surgery splenic rupture score, which was retrospectively calculated, and surgical management: splenectomy in 84% (n = 44) of cases with a severe score and in 58% (n = 70) of cases with a moderate or minor score (p = 0.001). The mortality rate of splenic rupture was 4.8% (n = 9). In splenic infarction, an underlying haematological condition was observed in 21% (n = 6) of cases. The treatment of splenic infarction was always conservative without any fatal outcomes. CONCLUSIONS: Similarly to traumatic splenic rupture, splenic preservation is increasingly common in the management of mononucleosis-associated cases as well. This complication is still occasionally fatal. Splenic infarction often occurs in subjects with a pre-existing haematological condition.
    Schlagwörter Medicine ; R
    Thema/Rubrik (Code) 630
    Sprache Englisch
    Erscheinungsdatum 2023-05-01T00:00:00Z
    Verlag SMW supporting association (Trägerverein Swiss Medical Weekly SMW)
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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