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  1. Artikel ; Online: Macula as a Window to Diagnosis.

    Sangeeth, Thuppanattumadam Ananthasubramanian / Padmanabha, Hansashree / Santhosh-Kumar, Rashmi / Chandra, Sadanandavalli R / Dhar, Debjyoti / Mailankody, Pooja / Santosh, Vani

    The Journal of pediatrics

    2020  Band 231, Seite(n) 284–285

    Mesh-Begriff(e) Child, Preschool ; Humans ; Macula Lutea ; Male ; Neuronal Ceroid-Lipofuscinoses/complications ; Neuronal Ceroid-Lipofuscinoses/diagnosis ; Retinal Diseases/etiology
    Sprache Englisch
    Erscheinungsdatum 2020-12-15
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2020.12.017
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: HyPE study: hydroxychloroquine prophylaxis-related adverse events' analysis among healthcare workers during COVID-19 pandemic: a rising public health concern.

    Nagaraja, Bada Sharanappa / Ramesh, Kalhalli Narayanaswamy / Dhar, Debjyoti / Mondal, Mahammad Samim / Dey, Treshita / Saha, Subhrakamal / Khan, Mumtaz Ali / Rutul, Shah Dhiren / Pratik, Kishore / Manjula, Jayaram / Sangeeth, Thuppanattumadam Ananthasubramanian / Singh, Vikram

    Journal of public health (Oxford, England)

    2020  Band 42, Heft 3, Seite(n) 493–503

    Abstract: Background: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature.: Methods: A ... ...

    Abstract Background: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature.
    Methods: A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis.
    Results: Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18-5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17-4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG.
    Conclusions: A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported.
    Mesh-Begriff(e) Adult ; Antiviral Agents/adverse effects ; Antiviral Agents/therapeutic use ; COVID-19 ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Cross-Sectional Studies ; Female ; Health Personnel/statistics & numerical data ; Humans ; Hydroxychloroquine/adverse effects ; Hydroxychloroquine/therapeutic use ; Incidence ; India/epidemiology ; Male ; Middle Aged ; Pandemics ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Public Health/statistics & numerical data ; Retrospective Studies ; Risk Assessment ; Risk Factors
    Chemische Substanzen Antiviral Agents ; Hydroxychloroquine (4QWG6N8QKH)
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-06-01
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2142082-8
    ISSN 1741-3850 ; 1741-3842
    ISSN (online) 1741-3850
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdaa074
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: HyPE study: hydroxychloroquine prophylaxis-related adverse events' analysis among healthcare workers during COVID-19 pandemic: a rising public health concern

    Nagaraja, Bada Sharanappa / Ramesh, Kalhalli Narayanaswamy / Dhar, Debjyoti / Mondal, Mahammad Samim / Dey, Treshita / Saha, Subhrakamal / Khan, Mumtaz Ali / Rutul, Shah Dhiren / Pratik, Kishore / Manjula, Jayaram / Sangeeth, Thuppanattumadam Ananthasubramanian / Singh, Vikram

    J Public Health (Oxf)

    Abstract: BACKGROUND: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. METHODS: A ... ...

    Abstract BACKGROUND: The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. METHODS: A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. RESULTS: Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd's ratio (OR): 2.44, 95% confidence interval (CI): 1.18-5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17-4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG. CONCLUSIONS: A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported.
    Schlagwörter covid19
    Verlag WHO
    Dokumenttyp Artikel
    Anmerkung WHO #Covidence: #505973
    Datenquelle COVID19

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  4. Artikel ; Online: HyPE study

    Nagaraja, Bada Sharanappa / Ramesh, Kalhalli Narayanaswamy / Dhar, Debjyoti / Mondal, Mahammad Samim / Dey, Treshita / Saha, Subhrakamal / Khan, Mumtaz Ali / Rutul, Shah Dhiren / Pratik, Kishore / Manjula, Jayaram / Sangeeth, Thuppanattumadam Ananthasubramanian / Singh, Vikram

    Journal of Public Health

    hydroxychloroquine prophylaxis-related adverse events’ analysis among healthcare workers during COVID-19 pandemic: a rising public health concern

    2020  Band 42, Heft 3, Seite(n) 493–503

    Abstract: Abstract Background The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods A ...

    Abstract Abstract Background The rising burden of Coronavirus disease (COVID-19) has led to the mass use of hydroxychloroquine by healthcare workers (HCWs). Adverse event profile of this drug when used as prophylaxis is not well known in the literature. Methods A retrospective, cross-sectional study was conducted across the country using semi-structured web-based questionnaire among COVID-19 negative and asymptomatic healthcare workers, taking hydroxychloroquine prophylaxis. Descriptive and multivariate logistic-regression models were applied for analysis. Results Of the 166 participants, at least one adverse event was experienced by 37.9% participants, gastrointestinal being the most common (30.7%). Risk was higher in participants <40 years age (odd’s ratio (OR): 2.44, 95% confidence interval (CI): 1.18–5.05) and after first dose of hydroxychloroquine (51.2%, OR: 2.38, 95%CI: 1.17–4.84). Hydroxychloroquine prophylaxis was initiated without electrocardiography by 80.1% of HCWs. Only 21.6% of those with cardiovascular disease could get prior ECG. Conclusions A higher incidence of adverse events was observed when results were compared with studies involving patients on long-term hydroxychloroquine therapy. Younger age and first dose were associated with greater incidence of adverse events though all were self-limiting. Monitoring prior and during prophylaxis was inadequate even among those with cardiovascular disease and risk-factors. However, no serious cardiovascular events were reported.
    Schlagwörter Public Health, Environmental and Occupational Health ; General Medicine ; covid19
    Sprache Englisch
    Verlag Oxford University Press (OUP)
    Erscheinungsland uk
    Dokumenttyp Artikel ; Online
    ZDB-ID 2142082-8
    ISSN 1741-3842
    ISSN 1741-3842
    DOI 10.1093/pubmed/fdaa074
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

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