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  1. Artikel ; Online: Nurses' perception of the impact of professional development sessions on their pre-hospital clinical practice with trauma victims.

    Mota, Mauro / Pires, Regina / Cunha, Madalena / Santos, Margarida Reis

    Frontiers in public health

    2024  Band 12, Seite(n) 1365509

    Abstract: Background: Continuing education is important for the quality of clinical practice because it complements it and focuses primarily on producing qualified pre-hospital nurses with operationally defined competence in nursing standards. The objective of ... ...

    Abstract Background: Continuing education is important for the quality of clinical practice because it complements it and focuses primarily on producing qualified pre-hospital nurses with operationally defined competence in nursing standards. The objective of this study was to assess pre-hospital nurses' opinion of the impact of professional development sessions on their clinical practice.
    Method: A descriptive and quantitative study was carried out involving Portuguese pre-hospital nurses. Six professional development sessions were presented in 2020 to pre-hospital registered nurses in four of Portugal's main cities. To collect the data, at the end of each session, we apply a questionnaire designed specifically for this study. This data collection instrument consists of 11 questions, six designed to evaluate the session and five designed to evaluate the trainer responsible for the session. A five-point Likert scale was used for each question, where 1 corresponds to very dissatisfied and 5 to extremely satisfied.
    Results: Two hundred and two nurses, which represents 55% of all Portuguese pre-hospital nurses, took part in the assessment of the professional development sessions. The nurses were from the Northern region of Portugal (51%;
    Conclusion: The professional development sessions provide pre-hospital nurses with the latest research findings and the majority of nurses considered that the training had a huge impact on their clinical practice. However, it is important that future research aims to explore the cause-effect relationship between training and improved clinical practice.
    Mesh-Begriff(e) Humans ; Portugal ; Surveys and Questionnaires ; Adult ; Female ; Male ; Attitude of Health Personnel ; Nurses/psychology ; Middle Aged ; Wounds and Injuries ; Education, Nursing, Continuing ; Perception
    Sprache Englisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2711781-9
    ISSN 2296-2565 ; 2296-2565
    ISSN (online) 2296-2565
    ISSN 2296-2565
    DOI 10.3389/fpubh.2024.1365509
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Eating habits: what foods do children between 12 and 36 months consume?

    Marinho, Catarina Saraiva / Koch, Cândida / Santos, Margarida Reis

    Revista brasileira de enfermagem

    2023  Band 76, Heft 4, Seite(n) e20220393

    Abstract: Objective: to identify toddlers' eating habits.: Method: a cross-sectional study of quantitative analysis, with a sample of 808 toddlers who attended day care centers in the district of Viseu, Portugal, between November 2018 and September 2019. Data ... ...

    Abstract Objective: to identify toddlers' eating habits.
    Method: a cross-sectional study of quantitative analysis, with a sample of 808 toddlers who attended day care centers in the district of Viseu, Portugal, between November 2018 and September 2019. Data were collected using a questionnaire directed at parents.
    Results: the prevalence of children who ate six meals a day was 42.8%, and 42.5%, those who ate five meals. It was found that 2.0% of children consumed chocolates, 1.0%, desserts, and 0.4%, carbonated beverages, daily. On average, dairy product (M=5.61; SD=2.62) and meat/fish/egg (M=4.80; SD=3.57) consumption was higher than recommended, while fat (M=0.48; SD=0.40), legume (M=0.49; SD=0.45), vegetable (M=1.18; SD=0.87) and water (M=0 .51; SD=0.29) consumption was lower.
    Conclusions: there was a higher or lower consumption than recommended for some foods, highlighting the need to implement nursing intervention programs aimed at promoting healthy eating habits in toddlers and families.
    Mesh-Begriff(e) Animals ; Humans ; Cross-Sectional Studies ; Energy Intake ; Feeding Behavior ; Vegetables ; Portugal
    Sprache Portugiesisch
    Erscheinungsdatum 2023-10-09
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/0034-7167-2022-0393
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  3. Artikel ; Online: CARM1 arginine methyltransferase as a therapeutic target for cancer.

    Santos, Margarida / Hwang, Jee Won / Bedford, Mark T

    The Journal of biological chemistry

    2023  Band 299, Heft 9, Seite(n) 105124

    Abstract: Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that posttranslationally modifies proteins that regulate multiple levels of RNA production and processing. Its substrates include histones, transcription factors, ...

    Abstract Coactivator-associated arginine methyltransferase 1 (CARM1) is an arginine methyltransferase that posttranslationally modifies proteins that regulate multiple levels of RNA production and processing. Its substrates include histones, transcription factors, coregulators of transcription, and splicing factors. CARM1 is overexpressed in many different cancer types, and often promotes transcription factor programs that are co-opted as drivers of the transformed cell state, a process known as transcription factor addiction. Targeting these oncogenic transcription factor pathways is difficult but could be addressed by removing the activity of the key coactivators on which they rely. CARM1 is ubiquitously expressed, and its KO is less detrimental in embryonic development than deletion of the arginine methyltransferases protein arginine methyltransferase 1 and protein arginine methyltransferase 5, suggesting that therapeutic targeting of CARM1 may be well tolerated. Here, we will summarize the normal in vivo functions of CARM1 that have been gleaned from mouse studies, expand on the transcriptional pathways that are regulated by CARM1, and finally highlight recent studies that have identified oncogenic properties of CARM1 in different biological settings. This review is meant to kindle an interest in the development of human drug therapies targeting CARM1, as there are currently no CARM1 inhibitors available for use in clinical trials.
    Mesh-Begriff(e) Animals ; Humans ; Mice ; Drug Delivery Systems ; Neoplasms/drug therapy ; Neoplasms/genetics ; Transcription Factors/metabolism ; Protein-Arginine N-Methyltransferases/antagonists & inhibitors ; Protein-Arginine N-Methyltransferases/genetics ; Protein-Arginine N-Methyltransferases/metabolism
    Chemische Substanzen coactivator-associated arginine methyltransferase 1 (EC 2.1.1.319) ; Transcription Factors ; Protein-Arginine N-Methyltransferases (EC 2.1.1.319)
    Sprache Englisch
    Erscheinungsdatum 2023-08-01
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Review
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2023.105124
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  4. Artikel: School engagement, school climate and youth externalizing behaviors: direct and indirect effects of parenting practices.

    da Fonseca, Inês Barbosa / Santos, Gilda / Santos, Margarida A

    Current psychology (New Brunswick, N.J.)

    2023  , Seite(n) 1–18

    Abstract: This research aimed to explore the direct and indirect effects of students' school engagement, school climate and parenting practices on youth's externalizing behaviors. A quantitative methodology with a sample of 183 Portuguese students, aged between 11 ...

    Abstract This research aimed to explore the direct and indirect effects of students' school engagement, school climate and parenting practices on youth's externalizing behaviors. A quantitative methodology with a sample of 183 Portuguese students, aged between 11 and 16 years old, was used. The main results suggested negative associations between externalizing behaviors and higher levels of school engagement and positive school climate. Poor parental supervision, inconsistent discipline and corporal punishment were positively related with externalizing behaviors, contrary to parental involvement and positive parenting that were associated with lower levels of externalizing behaviors. However, negative parenting practices were associated with lower levels of school engagement. Additionally, the results indicated that parenting practices might influence youth's externalizing behaviors through school engagement.
    Sprache Englisch
    Erscheinungsdatum 2023-03-25
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2021598-8
    ISSN 1936-4733 ; 1046-1310
    ISSN (online) 1936-4733
    ISSN 1046-1310
    DOI 10.1007/s12144-023-04567-4
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  5. Artikel ; Online: Occludin is overexpressed in tubo-ovarian high-grade serous carcinoma compared to mesothelioma and is a marker of tumor progression and chemoresistance.

    Dos Santos, Margarida Varela / Holth, Arild / Bischof, Katharina / Davidson, Ben

    Clinical & experimental metastasis

    2023  Band 41, Heft 1, Seite(n) 69–76

    Abstract: The objective of this study was to analyze the expression and prognostic role of the tight junction protein occludin in high-grade serous carcinoma (HGSC). Occludin protein expression by immunohistochemistry was analyzed in 602 HGSC (417 effusions, 185 ... ...

    Abstract The objective of this study was to analyze the expression and prognostic role of the tight junction protein occludin in high-grade serous carcinoma (HGSC). Occludin protein expression by immunohistochemistry was analyzed in 602 HGSC (417 effusions, 185 surgical specimens). Expression in mesothelioma (n = 87; 45 effusions, 42 surgical specimens) was studied for comparative purposes. Occludin protein expression was found in 587/602 (98%) HGSC vs. 40/87 (46%) mesotheliomas and was predominantly limited to < 5% of cells in the latter (p < 0.001). Occludin was additionally overexpressed in HGSC effusions compared to surgical specimens (p < 0.001) and was overexpressed in post-chemotherapy effusions compared to chemo-naive effusions tapped at diagnosis (p = 0.015). Occludin expression in HGSC surgical specimens was associated with poor chemoresponse (p < 0.001) and primary resistance (p = 0.001). Expression in effusions and surgical specimens was unrelated to survival (p > 0.05). In conclusion, occludin expression is higher in HGSC compared to mesothelioma, and this protein is overexpressed in HGSC effusions, possibly reflecting changes in adhesion related to anchorage-independent growth in this microenvironment. Overexpression in post-chemotherapy compared to chemo-naïve effusions suggest a role in disease progression. Occludin expression in surgical specimens may be related to chemoresistance.
    Mesh-Begriff(e) Female ; Humans ; Biomarkers, Tumor ; Carcinoma ; Cystadenocarcinoma, Serous/drug therapy ; Cystadenocarcinoma, Serous/metabolism ; Cystadenocarcinoma, Serous/pathology ; Drug Resistance, Neoplasm ; Mesothelioma/drug therapy ; Mesothelioma/pathology ; Occludin/genetics ; Ovarian Neoplasms/drug therapy ; Ovarian Neoplasms/surgery ; Tumor Microenvironment
    Chemische Substanzen Biomarkers, Tumor ; Occludin ; OCLN protein, human
    Sprache Englisch
    Erscheinungsdatum 2023-12-23
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 604952-7
    ISSN 1573-7276 ; 0262-0898
    ISSN (online) 1573-7276
    ISSN 0262-0898
    DOI 10.1007/s10585-023-10251-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1855: Hefte anzeigen Standort:
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  6. Artikel ; Online: Early detection of grapevine graft incompatibility: Insights into translocated and virus-induced incompatibility

    Tedesco, Sara / Irisarri, Patricia / Teixeira Santos, Margarida / Fevereiro, P. / Pina, Ana / Kragler, Friedrich

    Scientia Horticulturae. 2023 Aug., v. 318 p.112087-

    2023  

    Abstract: In vineyards to control phylloxera (Daktulosphaira vitifolia Ficth) attacks in Vitis vinifera L., heterografted vines are planted using American vines hybrids as rootstocks. However, graft incompatibilities can affect grape yield and plant longevity. ... ...

    Abstract In vineyards to control phylloxera (Daktulosphaira vitifolia Ficth) attacks in Vitis vinifera L., heterografted vines are planted using American vines hybrids as rootstocks. However, graft incompatibilities can affect grape yield and plant longevity. Thus, to identify early graft incompatibility factors, we established in vitro micrografting protocols coupled with histology and histochemistry analysis in grapevine graft combinations of known compatibility behavior. The histochemical characterization of the graft union revealed irregular cell arrangement, slower vascular differentiation, persistence of the necrotic layer, accumulation of starch, and lower differentiation of phloem cells in hetero- compared to homografts, indicating the presence of translocated incompatibility symptoms. We highlight the utility of evaluating the graft interface cellular arrangement and starch content via calcofluor and I₂KI staining, respectively, as allowed to identify the graft combinations with lower graft success. Wounded and grafted Syrah plantlets pointed out an impaired sucrose distribution in these plants and levels of Grapevine Rupestris Stem Pitting associated Virus (GRSPaV) infections correlated with graft (un)-success in two Syrah clones micrografted onto 110-Ritcher rootstock. Furthermore, silencing GRSPaV before grafting increased graft success rates. We propose that grapevine graft incompatibility is mainly a virus-induced phenomenon that can arise even in certified plants.
    Schlagwörter Daktulosphaira ; Vitis vinifera ; allografting ; graft compatibility ; grapes ; histochemistry ; longevity ; phloem ; plantlets ; rootstocks ; starch ; sucrose ; viruses ; Grapevine ; GRSPaV ; Histology ; Graft incompatibility ; In vitro culture ; Syrah
    Sprache Englisch
    Erscheinungsverlauf 2023-08
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version ; Use and reproduction
    ZDB-ID 185557-8
    ISSN 0304-4238
    ISSN 0304-4238
    DOI 10.1016/j.scienta.2023.112087
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: Nurses' perception of the nursing process and its relationship with leadership.

    Bär, Karen Ariane / Lima, Bianca Dos Santos / Martelle, Gicelle Morais / Silva, Silvana Cruz da / Santos, Margarida Reis Dos / Costenaro, Regina Gema Santini

    Revista brasileira de enfermagem

    2024  Band 77, Heft 1, Seite(n) e20230371

    Abstract: Objectives: to describe Nurses' perception of the Nursing Process and its relationship with leadership.: Methods: action research conducted between September/2021 and April/2022 with nurses from a medium-sized hospital in southern Brazil. The data ... ...

    Abstract Objectives: to describe Nurses' perception of the Nursing Process and its relationship with leadership.
    Methods: action research conducted between September/2021 and April/2022 with nurses from a medium-sized hospital in southern Brazil. The data investigated, one of the stages of the method, was collected using the Focus Group technique and submitted to Strategic Focus Analysis.
    Results: three categories emerged from the organized and analyzed data, namely: Nursing Process: a tool that qualifies nursing care; Conditions that weaken the Nursing Process; and Strategies that enhance the Systematization of Nursing Care.
    Final considerations: the perception of the Nursing Process and its relationship with leadership are not always understood as complementary themes. Although they recognize that the Nursing Process is sometimes imposed as normative, nurses do not perceive the importance of the role of the leader, who is considered a key player in conducting and boosting the Systematization of Nursing Care.
    Mesh-Begriff(e) Leadership ; Humans ; Brazil ; Focus Groups/methods ; Perception ; Female ; Male ; Nursing Process/trends ; Adult ; Nurses/psychology ; Attitude of Health Personnel ; Middle Aged ; Qualitative Research
    Sprache Portugiesisch
    Erscheinungsdatum 2024-04-22
    Erscheinungsland Brazil
    Dokumenttyp Journal Article
    ZDB-ID 731983-6
    ISSN 1984-0446 ; 0034-7167
    ISSN (online) 1984-0446
    ISSN 0034-7167
    DOI 10.1590/0034-7167-2023-0371
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel: Developing a hetero-intelligence methodological framework for sustainable policy-making based on the assessment of large language models.

    Buitrago-Esquinas, Eva M / Puig-Cabrera, Miguel / Santos, José António C / Custódio-Santos, Margarida / Yñiguez-Ovando, Rocío

    MethodsX

    2024  Band 12, Seite(n) 102707

    Abstract: This work delves into the increasing relevance of Large Language Models (LLMs) in the realm of sustainable policy-making, proposing an innovative hetero-intelligence framework that blends human and artificial intelligence (AI) for tackling modern ... ...

    Abstract This work delves into the increasing relevance of Large Language Models (LLMs) in the realm of sustainable policy-making, proposing an innovative hetero-intelligence framework that blends human and artificial intelligence (AI) for tackling modern sustainability challenges. The research methodology includes a hetero-intelligence performance test, which juxtaposes human intelligence with AI in the formulation and implementation of sustainable policies. After testing this hetero-intelligence methodology, seven steps are rigorously described so that it can be replicated in any sustainability planning related context. The results underscore the capabilities and limitations of LLMs, underscoring the critical role of human intelligence in enhancing the efficacy of hetero-intelligence systems. This work fulfils the need of a rigorous methodological framework based on empirical steps that can provide unbiased outcomes to be integrated into sustainable planning and decision-making processes.•Assesses LLMs' limitations and capabilities regarding sustainable planning issues•A replicable methodology is proposed based on the combination of both human and artificial intelligence•It proposes and systematises the integration of a hetero-intelligent approach into the formulation of sustainability policies to be more efficient and effective.
    Sprache Englisch
    Erscheinungsdatum 2024-04-14
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 2830212-6
    ISSN 2215-0161
    ISSN 2215-0161
    DOI 10.1016/j.mex.2024.102707
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  9. Artikel ; Online: Digital Educational Game "O Jardim do Ferro": A Tool for the Prevention of Iron Deficiency Anemia in Childhood.

    Beber, Rejane Bermudes Costa / Doviggi Meyer, Nicholas / Felipetto, Gabriel Rodrigues / Machado, Marianne / Santos, Margarida Reis / Vargas, Camila Lehnhart / Benedetti, Franceliane Jobim

    Games for health journal

    2024  Band 13, Heft 1, Seite(n) 50–56

    Abstract: Objective: ...

    Abstract Objective:
    Mesh-Begriff(e) Child, Preschool ; Humans ; Anemia, Iron-Deficiency/prevention & control ; Software ; Health Education ; Schools ; Iron
    Chemische Substanzen Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2024-02-02
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2650543-5
    ISSN 2161-7856 ; 2161-783X
    ISSN (online) 2161-7856
    ISSN 2161-783X
    DOI 10.1089/g4h.2023.0006
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  10. Artikel ; Online: A scoping review as an exploratory method to inform future research on nonpharmacological interventions to prevent anxiety in adolescents in the perioperative period.

    Pestana-Santos, Márcia / Reis Santos, Margarida / Lomba, Lurdes

    JBI evidence synthesis

    2021  Band 19, Heft 9, Seite(n) 2048–2049

    Mesh-Begriff(e) Adolescent ; Anxiety/prevention & control ; Anxiety Disorders ; Humans ; Perioperative Period ; Research Design
    Sprache Englisch
    Erscheinungsdatum 2021-08-26
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Comment
    ISSN 2689-8381
    ISSN (online) 2689-8381
    DOI 10.11124/JBIES-21-00311
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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