Artikel: Synapse loss may be a minor contributor to decreased regional cerebral blood flow in Alzheimer disease.
Dementia and geriatric cognitive disorders
2003 Band 15, Heft 2, Seite(n) 72–78
Abstract: In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 ... ...
Abstract | In this study we tested the hypothesis that synapse loss contributes to decreased regional cerebral blood flow (rCBF) in Alzheimer disease (AD). We compared antemortem rCBF and postmortem analysis of synaptophysin, as a measure of synapse loss, in 13 cases of AD. rCBF studies were performed using inhaled xenon gas (Xe-133), which yields quantitative results. Synapse loss was evaluated in postmortem brain samples using an enzyme-linked immunosorbant assay (ELISA) that measures synaptophysin, with results expressed as picomoles synaptophysin/10 mg brain. Synaptophysin was expressed either as concentration (QS method) or as the ratio of the concentration to the combined results in frontal, temporal and parietal lobe (RS method). There was no correlation between synapse loss and rCBF using the QS method and only borderline significance between right SPECT and right temporal synaptophysin using the RS method. The results of this study suggest that synapse loss may be a minor contributor to the decreased rCBF observed in AD. |
---|---|
Mesh-Begriff(e) | Aged ; Alzheimer Disease/pathology ; Alzheimer Disease/physiopathology ; Brain/blood supply ; Brain/pathology ; Brain/ultrastructure ; Case-Control Studies ; Cerebrovascular Circulation ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Male ; Synapses/pathology ; Synaptophysin/analysis ; Tomography, Emission-Computed, Single-Photon |
Chemische Substanzen | Synaptophysin |
Sprache | Englisch |
Erscheinungsdatum | 2003 |
Erscheinungsland | Switzerland |
Dokumenttyp | Comparative Study ; Journal Article ; Research Support, U.S. Gov't, P.H.S. |
ZDB-ID | 1026007-9 |
ISSN | 1420-8008 ; 1013-7424 |
ISSN | 1420-8008 ; 1013-7424 |
DOI | 10.1159/000067970 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
Zs.A 2866: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.