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Article ; Online: Voice disorders occurred as a result of the use of psychoactive substances

Ilić-Savić Ivana S. / Babac Snežana S.

Baština, Vol 2023, Iss 60, Pp 539-

2023 Volume 548

Abstract: Frequent use of psychoactive drugs, alcohol and tobacco can lead to pathological changes in the vocal cords. The aim of this study is to analyze the connection between the consumption of psychoactive substances and disturbances in the quality of the ... ...

Abstract	Frequent use of psychoactive drugs, alcohol and tobacco can lead to pathological changes in the vocal cords. The aim of this study is to analyze the connection between the consumption of psychoactive substances and disturbances in the quality of the voice by reviewing the previous literature. Voice disorders in users of psychoactive substances occur over time, due to the appearance of organic changes in the vocal apparatus. Marijuana smoke causes irritation of the mucous membrane of the larynx, which causes hoarseness and hoarseness in the voice. The effect of electronic cigarettes on voice quality is milder compared to the effect of conventional cigarettes. The results of this study also show that drug users have lower results in the domain of social functioning compared to alcohol and tobacco users. The findings of this study suggest that users of psychoactive substances have respiratory disorders and worse lung function, changes in vocal folds, disturbance of auditory and perceptual parameters of voice quality and worse quality of life. Additional implications suggest the necessary help and support of speech therapists in educating users of psychoactive substances about the ways of their use and their connection with voice disorders and quality of life as a whole.
Keywords	voice disorders ; psychoactive substances ; phonation ; voice quality ; History (General) and history of Europe ; D ; Social sciences (General) ; H1-99
Subject code	303
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Institute of Serbian Culture Priština, Leposavić
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Role of gap junctions and connexin 43 in cancerogenesis and tumor metastasis

Savić Ivana / Ivanović Nebojša / Oprić Dejan

Medicinski Podmladak, Vol 73, Iss 3, Pp 18-

2022 Volume 21

Abstract: Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation. They are composed of connexin proteins, of which the most common and most ... ...

Abstract	Gap junctions are intercellular connections that enable direct communication between neighboring cells. They are important in tissue homeostasis, cell growth, and differentiation. They are composed of connexin proteins, of which the most common and most studied is connexin 43. The role of connexin 43 in the development and progression of tumors is contradictory. The aim of this paper is to summarize the current state of knowledge on the expression of connexin 43 in various primary and secondary tumors, in order to explain its role in the development and progression of malignant tumors. Previous studies have examined the expression of connexin 43 in various primary and secondary tumors, as well as its association with prognosis. The expression of connexin 43 has been shown to be associated with various aspects of tumor behavior. However, it has been shown that the expression of connexin 43 differs between different types and localizations of tumors, as well as between different stages in tumor progression, which indicates the complex role of connexin 43 in tumor evolution. Since gap junctions play a role in carcinogenesis, invasion, and metastasis of malignant cells, further studies should clarify whether connexin 43 can be used as a diagnostic biomarker.
Keywords	gap junctions ; connexin 43 ; immunohistochemistry ; carcinoma ; Medicine ; R
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	University of Belgrade, Medical Faculty
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Update on Diagnosing and Reporting Malignant Pleural Mesothelioma.

Savic, Ivana / Myers, Jeffrey

Acta medica academica

2021 Volume 50, Issue 1, Page(s) 197–208

Abstract: In this review, we summarize current approaches to diagnosis of malignant pleural mesothelioma, focusing on the distinction from benign mesothelial proliferations and other malignant tumors. Current recommendations for reporting histological sub-type and ...

Abstract	In this review, we summarize current approaches to diagnosis of malignant pleural mesothelioma, focusing on the distinction from benign mesothelial proliferations and other malignant tumors. Current recommendations for reporting histological sub-type and tumor grade are also reviewed. Particular emphasis is placed on immunohistochemical and molecular tools that may help in establishing the diagnosis of mesothelioma with greater confidence. Immunohistochemical stains for BRCA1-associated protein (BAP1) and methylthioadenosine phosphorylase (MTAP) and homozygous deletion of p16 using fluorescence in situ hybridization (FISH) are emphasized as important methods for distinguishing benign from malignant mesothelial proliferations. CONCLUSIONS: Diffuse malignant pleural mesothelioma is a heterogeneous group of aggressive pleural tumors for which histological classification plays an increasingly important role in patient management. Stage and resectability remain key drivers of therapeutic strategies and outcomes. There is an increasingly robust suite of diagnostic tools, including immunohistochemical stains for BAP1 and MTAP and p16 FISH, for differentiating benign from malignant mesothelial proliferations in cytology and tissue specimens.
MeSH term(s)	Biomarkers, Tumor ; Diagnosis, Differential ; Homozygote ; Humans ; Immunohistochemistry ; In Situ Hybridization, Fluorescence ; Lung Neoplasms ; Mesothelioma, Malignant ; Sequence Deletion ; Tumor Suppressor Proteins/genetics ; Ubiquitin Thiolesterase/genetics
Chemical Substances	BAP1 protein, human ; Biomarkers, Tumor ; Tumor Suppressor Proteins ; Ubiquitin Thiolesterase (EC 3.4.19.12)
Language	English
Publishing date	2021-06-02
Publishing country	Bosnia and Herzegovina
Document type	Journal Article ; Review
ZDB-ID	2558604-X
ISSN	1840-2879 ; 1840-1848
ISSN (online)	1840-2879
ISSN	1840-1848
DOI	10.5644/ama2006-124.335
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Pathogenesis of Pulmonary Calcification and Homologies with Biomineralization in Other Tissues.

Savic, Ivana / Farver, Carol / Milovanovic, Petar

The American journal of pathology

2022 Volume 192, Issue 11, Page(s) 1496–1505

Abstract: Lungs often present tissue calcifications and even ossifications, both in the context of high or normal serum calcium levels. Precise mechanisms governing lung calcifications have not been explored. Herein, we emphasize recent advances about ... ...

Abstract	Lungs often present tissue calcifications and even ossifications, both in the context of high or normal serum calcium levels. Precise mechanisms governing lung calcifications have not been explored. Herein, we emphasize recent advances about calcification processes in other tissues (especially vascular and bone calcifications) and discuss potential sources of calcium precipitates in the lungs, involvement of mineralization promoters and crystallization inhibitors, as well as specific cytokine milieu and cellular phenotypes characteristic for lung diseases, which may be involved in pulmonary calcifications. Further studies are necessary to demonstrate the exact mechanisms underlying calcifications in the lungs, document homologies in biomineralization processes between various tissues in physiological and pathologic conditions, and unravel any locally specific characteristics of mineralization processes that may be targeted to reduce or prevent functionally relevant lung calcifications without negatively affecting the skeleton.
Language	English
Publishing date	2022-08-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2943-9
ISSN	1525-2191 ; 0002-9440
ISSN (online)	1525-2191
ISSN	0002-9440
DOI	10.1016/j.ajpath.2022.07.015
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Article: Expression of connexin-43 in surgical resections of primary tumor and lymph node metastases of squamous cell carcinoma and adenocarcinoma of the lung: a retrospective study.

Savic, Ivana / Milovanovic, Petar / Opric, Svetlana / Ivanovic, Nebojsa / Oprić, Dejan

PeerJ

2022 Volume 10, Page(s) e13055

Abstract: Background: Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood. The objective of the study was to ... ...

Abstract	Background: Connexins are transmembrane proteins forming gap junctions between the cells, which allow intercellular communication. Significance of gap junctions and connexins in lung carcinoma is not yet understood. The objective of the study was to investigate immunohistochemical expression and the localization of connexin-43 (Cx43) in primary lung carcinoma and its lymphatic metastases. Methods: Surgical specimens of excised tumors from 88 patients (45 men and 43 women, 61.9 ± 7.4 years) with lung carcinoma (52 adenocarcinoma (AC), 36 squamous cell carcinoma (SqCC)) who were operated on at the University Hospital "Bezanijska Kosa" in a five-year period (2012-2016) were used. We conducted immunohistochemical staining for Cx43 and measured the degree of expression (percentage of positive cells and staining intensity) as well as localization of Cx43 in primary tumor and in lymphatic metastases. Results: Immunohistochemical analysis of the primary tumors revealed that SqCC showed significantly higher percentage of tumor cells expressing Cx43 as well as higher staining intensity than AC ( Conclusion: The results of this study showed that lung carcinomas express Cx43 in more than 65% of cases and that it was aberrantly localized (not membranous localization). We highlighted that SqCC expressed Cx43 more than did AC, both in primary tumor and lymphatic metastases. Further research is needed to establish whether Cx43 could be used as a prognostic biomarker in lung carcinoma.
Language	English
Publishing date	2022-03-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2703241-3
ISSN	2167-8359
ISSN	2167-8359
DOI	10.7717/peerj.13055
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Article ; Online: Recovery of yellow fever virus whole genome from an individual with severe vaccine-associated viscerotropic disease.

Walker, Harry N / Caly, Leon / Savic, Ivana / Aziz, Ammar / Tran, Thomas / Whitley, Megan / Chavada, Ruchir / Lim, Chuan Kok

The Lancet. Microbe

2024 Volume 5, Issue 5, Page(s) e414

MeSH term(s)	Humans ; Yellow fever virus/genetics ; Yellow fever virus/immunology ; Yellow Fever/prevention & control ; Yellow Fever/immunology ; Yellow Fever Vaccine/adverse effects ; Yellow Fever Vaccine/immunology ; Genome, Viral ; Male ; Phylogeny
Chemical Substances	Yellow Fever Vaccine
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Case Reports ; Research Support, Non-U.S. Gov't ; Letter ; Journal Article
ISSN	2666-5247
ISSN (online)	2666-5247
DOI	10.1016/S2666-5247(23)00395-6
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Article ; Online: Discrepancies between clinical and autopsy diagnosis of cause of death among psychiatric patients who died due to natural causes. A retrospective autopsy study

Mitrović Dragan / Savić Ivana / Janković Radmila

Vojnosanitetski Pregled, Vol 76, Iss 3, Pp 278-

2019 Volume 283

Abstract: Background/Aim. Autopsy studies rarely investigate the causes of natural death in psychiatric population. The aim of this study was to examine the causes of death among the subjects with various psychiatric disorders in whom a clinical (pathoanatomical) ... ...

Abstract	Background/Aim. Autopsy studies rarely investigate the causes of natural death in psychiatric population. The aim of this study was to examine the causes of death among the subjects with various psychiatric disorders in whom a clinical (pathoanatomical) autopsy was requested. Methods. The study group included 118 patients (65% men, 35% women, mean age 58.2 ± 13.6 years) with a psychiatric diagnosis, in whom a clinical autopsy was performed. We compared the distribution of causes of natural death among psychiatric patients and other patients, representatives of the general population who died of natural causes. We also analyzed the difference between clinical diagnoses of cause of death and the autopsy findings in psychiatric patients. Results. Psychiatric patients died earlier than the control group (58 vs. 69 years), usually due to the respiratory (46%) and cardiovascular diseases (37%). The most common diagnoses in psychiatric patients were organic psychoses and dementias (F00-F09) and schizophrenia and schizoaffective disorders (F20-F29). Majority of the patients (55%) died in general hospitals vs. specialized psychiatric hospitals (45%) due to somatic diseases. There was a significant difference in the distribution of causes of death compared to the control group in which the cardiovascular diseases dominated. Even in 64% of psychiatric patients there was a discrepancy between the clinical diagnosis of the cause of death and definite autopsy findings. Conclusion. The assessment of somatic diseases in psychiatric patients is insufficient, especially in specialized psychiatric hospitals. That leads to a significant discrepancy between clinical diagnosis of the cause of death and autopsy findings. Therefore, it is necessary to pay additional attention in diagnostics and treatment of somatic diseases in these patients to improve their health care.
Keywords	autopsy ; cause of death ; death ; sudden ; diagnosis ; hospitals ; general ; psychiatric ; mental disorders ; patients ; Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2019-01-01T00:00:00Z
Publisher	Military Health Department, Ministry of Defance, Serbia
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book ; Online: The origin of the lattice thermal conductivity enhancement at the ferroelectric phase transition in GeTe

Dangić, Đorđe / Hellman, Olle / Fahy, Stephen / Savić, Ivana

2020

Abstract: The proximity to structural phase transitions in IV-VI thermoelectric materials is one of the main reasons for their large phonon anharmonicity and intrinsically low lattice thermal conductivity $\kappa$. However, the $\kappa$ of GeTe increases at the ... ...

Abstract	The proximity to structural phase transitions in IV-VI thermoelectric materials is one of the main reasons for their large phonon anharmonicity and intrinsically low lattice thermal conductivity $\kappa$. However, the $\kappa$ of GeTe increases at the ferroelectric phase transition near $700$ K. Using first-principles calculations with the temperature dependent effective potential method, we show that this rise in $\kappa$ is the consequence of negative thermal expansion in the rhombohedral phase and increase in the phonon lifetimes in the high-symmetry phase. Negative thermal expansion increases phonon group velocities, which counteracts enhanced anharmonicity of phonon modes and boosts $\kappa$ close to the phase transition in the rhombohedral phase. A drastic decrease in the anharmonic force constants in the cubic phase increases the phonon lifetimes and $\kappa$. Strong anharmonicity near the phase transition induces non-Lorentzian shapes of the phonon power spectra. To account for these effects, we implement a novel method of calculating $\kappa$ based on the Green-Kubo approach and find that the Boltzmann transport equation underestimates $\kappa$ near the phase transition. Our findings elucidate the influence of structural phase transitions on $\kappa$ and provide guidance for design of better thermoelectric materials.
Keywords	Condensed Matter - Materials Science
Subject code	539
Publishing date	2020-12-15
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: "Heart in DRESS": Cardiac Manifestations, Treatment and Outcome of Patients with Drug Reaction with Eosinophilia and Systemic Symptoms Syndrome: A Systematic Review.

Radovanovic, Milan / Jevtic, Djordje / Calvin, Andrew D / Petrovic, Marija / Paulson, Margaret / Rueda Prada, Libardo / Sprecher, Lawrence / Savic, Ivana / Dumic, Igor

Journal of clinical medicine

2022 Volume 11, Issue 3

Abstract: Cardiac involvement in drug reaction with eosinophilia and systemic symptoms (DS) is rare but associated with high mortality. The aim of this research was to systematically review case reports by PRISMA guidelines in order to synthetize the knowledge of ... ...

Abstract	Cardiac involvement in drug reaction with eosinophilia and systemic symptoms (DS) is rare but associated with high mortality. The aim of this research was to systematically review case reports by PRISMA guidelines in order to synthetize the knowledge of cardiac manifestations of DS. We identified 42 cases from 36 case reports. Women were two times more affected than men. Two-thirds of patients had cardiac manifestation in the initial phase of the disease, while in one-third of cases cardiac manifestations developed later (mean time of 70 ± 63 days). The most common inciting medications were minocycline (19%) and allopurinol (12%). In 17% of patients, the heart was the only internal organ affected, while the majority (83%) had at least one additional organ involved, most commonly the liver and the kidneys. Dyspnea (55%), cardiogenic shock (43%), chest pain (38%), and tachycardia (33%) were the most common cardiac signs and symptoms reported. Patients frequently had an abnormal ECG (71.4%), and a decrease in left ventricular ejection fraction was the most common echocardiographic finding (45%). Endomyocardial biopsy or histological examination at autopsy was performed in 52.4%, with the predominant finding being fulminant eosinophilic myocarditis with acute necrosis in 70% of those biopsied. All patients received immunosuppressive therapy with intravenous steroids, while non-responders were more likely to have received IVIG, cyclosporine, mycophenolate, and other steroid-sparing agents (60%). Gender and degree of left ventricular systolic dysfunction were not associated with outcomes, but short latency between drug exposure and the first DRESS symptom onset (<15 days) and older age (above 65 years) was associated with death. This underscores the potential importance of heightened awareness and early treatment.
Language	English
Publishing date	2022-01-28
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm11030704
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Book ; Online: Temperature induced band convergence, intervalley scattering and thermoelectric transport in p-type PbTe

D'Souza, Ransell / Querales-Flores, José D. / Cao, Jiang / Fahy, Stephen / Savić, Ivana

2022

Abstract: Achieving high valley degeneracy (i.e. "band convergence") in a material usually results in considerably enhanced thermoelectric properties. However, it is still unclear why this strategy of designing efficient thermoelectric materials is so successful, ... ...

Abstract	Achieving high valley degeneracy (i.e. "band convergence") in a material usually results in considerably enhanced thermoelectric properties. However, it is still unclear why this strategy of designing efficient thermoelectric materials is so successful, since the benefit of increased density of states may be severely degraded by intervalley scattering. Using first-principles calculations, we investigate these effects in $p$-type PbTe, where temperature induces alignment of the $L$ and $\Sigma$ valleys at $\sim$~620~K. We explicitly show that the thermoelectric power factor and figure of merit peak near the band convergence temperature. The figure of merit maximum is larger than those of the individual $L$ and $\Sigma$ valleys. Surprisingly, intervalley scattering does not considerably affect the figure of merit near the band convergence temperature and optimal doping conditions, although it reduces the power factor by almost a factor of 2. Our results suggest that band convergence will significantly increase the figure of merit if intervalley scattering is roughly proportional to the density of states and the lattice thermal conductivity is considerably lower than the electronic thermal conductivity, even if intervalley scattering is strong. Comment: 15 pages, 6 figures, Journal publication
Keywords	Condensed Matter - Materials Science ; Physics - Computational Physics
Subject code	530
Publishing date	2022-05-27
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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