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  1. Artikel: Human Saposin B Ligand Binding and Presentation to α-Galactosidase A.

    Sawyer, Thomas K / Aral, Efecan / Staros, James V / Bobst, Cedric E / Garman, Scott C

    bioRxiv : the preprint server for biology

    2024  

    Abstract: Sphingolipid activator protein B (saposin B; SapB) is an essential activator of globotriaosylceramide (Gb3) catabolism by α-galactosidase A. However, the manner by which SapB stimulates α-galactosidase A activity remains unknown. To uncover the molecular ...

    Abstract Sphingolipid activator protein B (saposin B; SapB) is an essential activator of globotriaosylceramide (Gb3) catabolism by α-galactosidase A. However, the manner by which SapB stimulates α-galactosidase A activity remains unknown. To uncover the molecular mechanism of SapB presenting Gb3 to α-galactosidase A, we subjected the fluorescent substrate globotriaosylceramide-nitrobenzoxidazole (Gb3-NBD) to a series of biochemical and structural assays involving SapB. First, we showed that SapB stably binds Gb3-NBD using a fluorescence equilibrium binding assay, isolates Gb3-NBD from micelles, and facilitates α-galactosidase A cleavage of Gb3-NBD
    Sprache Englisch
    Erscheinungsdatum 2024-04-04
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2024.04.04.584535
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Buch: The scientist as consultant

    Sindermann, Carl J. / Sawyer, Thomas K.

    building new career opportunities

    1997  

    Verfasserangabe Carl J. Sindermann and Thomas K. Sawyer
    Schlagwörter Wissenschaftler ; Unternehmensberatung ; Berufsplanung
    Schlagwörter Beruf ; Betriebsberatung ; Unternehmen ; Managementberatung ; Management ; Wirtschaftsberatung ; Consulting ; Forscher ; Wissenschaftler ; Wissenschaftliche Elite
    Sprache Englisch
    Umfang XIV, 341 S.
    Verlag Plenum Trade
    Erscheinungsort New York u.a.
    Erscheinungsland Vereinigte Staaten
    Dokumenttyp Buch
    HBZ-ID HT008743039
    ISBN 0-306-45637-0 ; 978-0-306-45637-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Artikel ; Online: The integrin-growth factor receptor duet.

    Alam, Naved / Goel, Hira Lal / Zarif, Matthew J / Butterfield, Julie E / Perkins, Hillary M / Sansoucy, Brian G / Sawyer, Thomas K / Languino, Lucia R

    Journal of cellular physiology

    2007  Band 213, Heft 3, Seite(n) 649–653

    Abstract: Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli ... ...

    Abstract Cell adhesion receptors, referred to as integrins, are recognized as key regulators of cellular processes including growth and differentiation. Integrins communicate with growth factor receptors (GFRs) to control specific cellular responses to stimuli originating in the extracellular environment. In this article, we review the role of integrins as molecular switches that modulate GFR activation and specificity. We also examine the reciprocal modulation of integrin functions by GFRs and the mechanisms through which those actions are fine-tuned.
    Mesh-Begriff(e) Animals ; Forecasting ; Humans ; Integrins/metabolism ; Ligands ; Models, Biological ; Receptors, Growth Factor/metabolism
    Chemische Substanzen Integrins ; Ligands ; Receptors, Growth Factor
    Sprache Englisch
    Erscheinungsdatum 2007-12
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.21278
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch: Marine Flora and fauna of the northeastern United States

    Bovee, Eugene C / Sawyer, Thomas K

    Protozoa: Sarcodina: Amoebae

    (NOAA Technical Report : NMFS Circular ; 419)

    1979  

    Verfasserangabe Eugene C. Bovee and Thomas K. Sawyer
    Serientitel NOAA Technical Report : NMFS Circular ; 419
    Sprache Englisch
    Umfang III, 56 S
    Verlag U.S. Department of Commerce
    Erscheinungsort Seattle
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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