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  1. Book ; Thesis: Is novel always better? - the effects of warfarin and dabigatran anticoagulation in the event of traumatic brain injury

    Schäfer, Jan Hendrik

    2016  

    Author's details vorgelegt von Jan Hendrik Schäfer
    Language English
    Size 37 Seiten, Illustrationen, Diagramme
    Publishing place Frankfurt am Main
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Dissertation, Johann Wolfgang Goethe-Universität Frankfurt am Main, 2016
    Note Zusammenfassung in deutscher und englischer Sprache ; Enthält einen Sonderabdruck
    HBZ-ID HT019265136
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2017 E 406 order for loan Magazin

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  2. Book ; Thesis: Biomechanische Effekte der intervertebralen Applikation der Wachstumsfaktoren BMP-2, IGF-1 und TGF-beta1 an der Halswirbelsäule des Schafs

    Schaefer, Jan

    2003  

    Author's details vorgelegt von Jan Schaefer
    Language German
    Size 50 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Berlin, Humboldt-Univ., Diss., 2003
    HBZ-ID HT013845150
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2002 MB 5688 order for loan Magazin

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  3. Article: Feasibility and comparability of different platelet function tests in acute stroke with or without prior antiplatelet therapy.

    Schaefer, Jan Hendrik / Lieschke, Franziska / Urban, Hans / Bohmann, Ferdinand O / Gatzke, Florian / Miesbach, Wolfgang

    Frontiers in neurology

    2024  Volume 15, Page(s) 1361751

    Abstract: Background: The clinical course of ischemic and hemorrhagic strokes can be influenced by the coagulation status of individual patients. The prior use of antiplatelet therapy (APT) such as acetylsalicylic acid (ASA) or P2Y12-antagonists has been ... ...

    Abstract Background: The clinical course of ischemic and hemorrhagic strokes can be influenced by the coagulation status of individual patients. The prior use of antiplatelet therapy (APT) such as acetylsalicylic acid (ASA) or P2Y12-antagonists has been inconsistently described as possibly increasing the risk of hemorrhagic transformation or expansion. Since clinical studies describing prior use of antiplatelet medication are overwhelmingly lacking specific functional tests, we aimed to implement testing in routine stroke care.
    Methods: We used fluorescence-activated cell sorting (FACS) with antibodies against CD61 for thrombocyte identification and CD62p or platelet activation complex-1 (PAC-1) to determine platelet activation. Aggregometry and automated platelet functioning analyzer (PFA-200) were employed to test thrombocyte reactivity. FACS and aggregometry samples were stimulated
    Results: Between February and July 2023, 20 blood samples (
    Conclusion: In the clinical setting it is feasible to use differentiated platelet analytics to determine alterations caused by antiplatelet therapy. Among the tests under investigation, PFA-200 showed the highest sensitivity for the intake of ASA in stroke patients. FACS analysis on the other hand might be able to provide a more nuanced approach to altered platelet reactivity.
    Language English
    Publishing date 2024-02-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2024.1361751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Thesis: Frühpostoperative Lebensqualität

    Schäfer, Jan Raimund

    Thorakoskopie versus Thorakotomie

    1997  

    Author's details vorgelegt von Jan Raimund Schäfer
    Keywords Thorakoskopie ; Postoperative Phase ; Befindlichkeit ; Thorakotomie
    Subject Brustkorberöffnung ; Befinden ; Subjektive Befindlichkeit
    Language German
    Size II, 58 Bl.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Münster (Westfalen), Univ., Diss., 1997
    Note Mikrofiche-Ausg.: 1 Mikrofiche : 24x
    HBZ-ID HT008504273
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1998 MB 832 order for loan Magazin

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  5. Article ; Online: Chemical Gradients in Polymer-Modified Paper Sheets-Towards Single-Layer Biomimetic Soft Robots.

    Schäfer, Jan-Lukas / Meckel, Tobias / Poppinga, Simon / Biesalski, Markus

    Biomimetics (Basel, Switzerland)

    2023  Volume 8, Issue 1

    Abstract: Biomimetic actuators are typically constructed as functional bi- or multilayers, where actuating and resistance layers together dictate bending responses upon triggering by environmental stimuli. Inspired by motile plant structures, like the stems of the ...

    Abstract Biomimetic actuators are typically constructed as functional bi- or multilayers, where actuating and resistance layers together dictate bending responses upon triggering by environmental stimuli. Inspired by motile plant structures, like the stems of the false rose of Jericho (
    Language English
    Publishing date 2023-01-18
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2313-7673
    ISSN (online) 2313-7673
    DOI 10.3390/biomimetics8010043
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Book ; Online ; Thesis: Chemische Vernetzung von photo-reaktiven Copolymeren in cellulosebasiertem Papier – auf dem Weg zu einem besseren Verständnis der Nassfestigkeitseigenschaften und multifunktionalen Papieren

    Schäfer, Jan-Lukas [Verfasser] / Biesalski, Markus [Akademischer Betreuer] / Andrieu-Brunsen, Annette [Akademischer Betreuer]

    2024  

    Author's details Jan-Lukas Schäfer ; Markus Biesalski, Annette Andrieu-Brunsen
    Keywords Naturwissenschaften ; Science
    Subject code sg500
    Language German
    Publisher Universitäts- und Landesbibliothek
    Publishing place Darmstadt
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

    Full text online

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  7. Article ; Online: Adamant: a JSON schema-based metadata editor for research data management workflows.

    Chaerony Siffa, Ihda / Schäfer, Jan / Becker, Markus M

    F1000Research

    2022  Volume 11, Page(s) 475

    Abstract: The web tool Adamant has been developed to systematically collect research metadata as early as the conception of the experiment. Adamant enables a continuous, consistent, and transparent research data management (RDM) process, which is a key element of ... ...

    Abstract The web tool Adamant has been developed to systematically collect research metadata as early as the conception of the experiment. Adamant enables a continuous, consistent, and transparent research data management (RDM) process, which is a key element of good scientific practice ensuring the path to Findable, Accessible, Interoperable, Reusable (FAIR) research data. It simplifies the creation of on-demand metadata schemas and the collection of metadata according to established or new standards. The approach is based on JavaScript Object Notation (JSON) schema, where any valid schema can be presented as an interactive web-form. Furthermore, Adamant eases the integration of numerous available RDM methods and software tools into the everyday research activities of especially small independent laboratories. A programming interface allows programmatic integration with other software tools such as electronic lab books or repositories. The user interface (UI) of Adamant is designed to be as user friendly as possible. Each UI element is self-explanatory and intuitive to use, which makes it accessible for users that have little to no experience with JSON format and programming in general. Several examples of research data management workflows that can be implemented using Adamant are introduced. Adamant (client-only version) is available from: https://plasma-mds.github.io/adamant.
    MeSH term(s) Data Management ; Humans ; Metadata ; Software ; Workflow
    Language English
    Publishing date 2022-04-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2699932-8
    ISSN 2046-1402 ; 2046-1402
    ISSN (online) 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.110875.2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Die Auswahl des Schiedsrichters

    Schäfer, Jan K

    M & A review : Mergers & acquisitions : Beteiligungen, Allianzen, Restrukturierungen, Divestments, Private equity Vol. 29, No. 4 , p. 120-124

    2018  Volume 29, Issue 4, Page(s) 120–124

    Author's details Jan K. Schäfer
    Language German
    Publisher GoingPublic Media
    Publishing place München
    Document type Article
    ZDB-ID 2650403-0
    ISSN 1616-0878
    Database ECONomics Information System

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  9. Article ; Online: Structure of the metazoan Rab7 GEF complex Mon1-Ccz1-Bulli.

    Herrmann, Eric / Schäfer, Jan-Hannes / Wilmes, Stephan / Ungermann, Christian / Moeller, Arne / Kümmel, Daniel

    Proceedings of the National Academy of Sciences of the United States of America

    2023  Volume 120, Issue 20, Page(s) e2301908120

    Abstract: The endosomal system of eukaryotic cells represents a central sorting and recycling compartment linked to metabolic signaling and the regulation of cell growth. Tightly controlled activation of Rab GTPases is required to establish the different domains ... ...

    Abstract The endosomal system of eukaryotic cells represents a central sorting and recycling compartment linked to metabolic signaling and the regulation of cell growth. Tightly controlled activation of Rab GTPases is required to establish the different domains of endosomes and lysosomes. In metazoans, Rab7 controls endosomal maturation, autophagy, and lysosomal function. It is activated by the guanine nucleotide exchange factor (GEF) complex Mon1-Ccz1-Bulli (MCBulli) of the tri-longin domain (TLD) family. While the Mon1 and Ccz1 subunits have been shown to constitute the active site of the complex, the role of Bulli remains elusive. We here present the cryo-electron microscopy (cryo-EM) structure of MCBulli at 3.2 Å resolution. Bulli associates as a leg-like extension at the periphery of the Mon1 and Ccz1 heterodimers, consistent with earlier reports that Bulli does not impact the activity of the complex or the interactions with recruiter and substrate GTPases. While MCBulli shows structural homology to the related ciliogenesis and planar cell polarity effector (Fuzzy-Inturned-Wdpcp) complex, the interaction of the TLD core subunits Mon1-Ccz1 and Fuzzy-Inturned with Bulli and Wdpcp, respectively, is remarkably different. The variations in the overall architecture suggest divergent functions of the Bulli and Wdpcp subunits. Based on our structural analysis, Bulli likely serves as a recruitment platform for additional regulators of endolysosomal trafficking to sites of Rab7 activation.
    MeSH term(s) Animals ; Vesicular Transport Proteins/metabolism ; Cryoelectron Microscopy ; Protein Transport ; rab GTP-Binding Proteins/metabolism ; Endosomes/metabolism ; Guanine Nucleotide Exchange Factors/metabolism
    Chemical Substances Vesicular Transport Proteins ; rab GTP-Binding Proteins (EC 3.6.5.2) ; Guanine Nucleotide Exchange Factors
    Language English
    Publishing date 2023-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 209104-5
    ISSN 1091-6490 ; 0027-8424
    ISSN (online) 1091-6490
    ISSN 0027-8424
    DOI 10.1073/pnas.2301908120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1148: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  10. Article ; Online: Prevalence, recovery and phenotype of dysphagia in patients with ischaemic cerebellar stroke.

    Schaefer, Jan Hendrik / Luft, Felix / Seiler, Alexander / Harborth, Elena / Kaffenberger, Sara / Polkowski, Christoph / Foerch, Christian / Lapa, Sriramya

    European journal of neurology

    2024  , Page(s) e16303

    Abstract: Background and purpose: Swallowing is a complex task, moderated by a sophisticated bilateral network including multiple supratentorial regions, the brainstem and the cerebellum. To date, conflicting data exist about whether focal lesions to the ... ...

    Abstract Background and purpose: Swallowing is a complex task, moderated by a sophisticated bilateral network including multiple supratentorial regions, the brainstem and the cerebellum. To date, conflicting data exist about whether focal lesions to the cerebellum are associated with dysphagia. Therefore, the aim of the study was to evaluate dysphagia prevalence, recovery and dysphagia pattern in patients with ischaemic cerebellar stroke.
    Methods: A retrospective analysis of patients consecutively admitted to an academic stroke centre with ischaemic stroke found only in the cerebellum was performed. The presence of dysphagia was the primary end-point and was assessed by a speech-language pathologist, according to defined criteria. Dysphagia pattern was evaluated by analysing the videos of the flexible endoscopic evaluation of swallowing. Brain imaging was used to identify lesion size and location associated with dysphagia.
    Results: Between January 2016 and December 2021, 102 patients (35.3% female) with a mean age of 52.8 ± 17.3 years were included. Thirteen (12.7%) patients presented with dysphagia. The most frequently observed flexible endoscopic evaluation of swallowing phenotype was premature spillage (n = 7; 58.3%), whilst significant residues or aspiration did not occur. One patient died (7.7%); the other patients showed improvement of dysphagia and one patient (7.7%) was discharged with dietary restrictions.
    Conclusions: Although the involvement of the cerebellum in deglutition has become increasingly evident, isolated lesions to the cerebellum are less likely to cause clinically relevant and persisting dysphagia compared to other brain regions. The observed dysphagia pattern shows a lack of coordination and control, resulting in premature spillage or fragmented bolus transfer in some patients.
    Language English
    Publishing date 2024-04-17
    Publishing country England
    Document type Journal Article
    ZDB-ID 1280785-0
    ISSN 1468-1331 ; 1351-5101 ; 1471-0552
    ISSN (online) 1468-1331
    ISSN 1351-5101 ; 1471-0552
    DOI 10.1111/ene.16303
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4738: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 592: Show issues

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