Artikel ; Online: GPR52 regulates cAMP in T cells but is dispensable for encephalitogenic responses.
2023 Band 13, Seite(n) 1113348
Abstract: G-protein coupled receptors (GPCR) regulate 3',5'-cyclic adenosine monophosphate (cAMP) levels in T cells. cAMP as ubiquitous second messenger is crucial for adequate physiology of T cells by mediating effector T cell (Teff) function as well as ... ...
| Abstract | G-protein coupled receptors (GPCR) regulate 3',5'-cyclic adenosine monophosphate (cAMP) levels in T cells. cAMP as ubiquitous second messenger is crucial for adequate physiology of T cells by mediating effector T cell (Teff) function as well as regulatory T cell (Treg)-mediated immunosuppression. Several GPCRs have been identified to be crucial for Teff and Treg function. However, the role of the orphan, constitutively active Gs-coupled GPCR GPR52 is unknown. Here we show that GPR52 regulates cAMP levels in T cells but does not affect T cell function. We found that stimulation of transfected HEK cells or primary T cells with a GPR52 agonist results in a rise of intracellular cAMP. However, neither |
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| Mesh-Begriff(e) | Animals ; Cell Differentiation ; Cyclic AMP ; Encephalomyelitis, Autoimmune, Experimental/genetics ; Receptors, G-Protein-Coupled/genetics ; Receptors, G-Protein-Coupled/agonists ; T-Lymphocytes, Regulatory ; Humans |
| Chemische Substanzen | Cyclic AMP (E0399OZS9N) ; Receptors, G-Protein-Coupled |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-01-24 |
| Erscheinungsland | Switzerland |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 2606827-8 |
| ISSN | 1664-3224 ; 1664-3224 |
| ISSN (online) | 1664-3224 |
| ISSN | 1664-3224 |
| DOI | 10.3389/fimmu.2022.1113348 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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