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  1. Buch ; Dissertation / Habilitation: Vergleichende Untersuchung der nicht-invasiven Flussmessung im Truncus pulmonalis zwischen Probanden, Leistungssportlern und Patienten mit pulmonal-arterieller Hypertonie

    Schindler, Tobias

    2008  

    Verfasserangabe vorgelegt von Tobias Schindler
    Sprache Deutsch
    Umfang 104 S., graph. Darst., 29 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Dresden, Techn. Univ., Diss., 2008
    HBZ-ID HT016131602
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2010 E 478 bestellbar zur Ausleihe Magazin

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  2. Buch ; Dissertation / Habilitation: Marknagelungstechniken an den großen Röhrenknochen der unteren Extremität im Klinikum Hof

    Schindler, Tobias

    eine Analyse des Krankengutes der Jahre 1994 - 1997

    2000  

    Verfasserangabe vorgelegt von Tobias Schindler
    Sprache Deutsch
    Umfang 72 Bl., Ill., graph. Darst.
    Ausgabenhinweis [Mikrofiche-Ausg.]
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Erlangen, Nürnberg, Univ., Diss., 2000
    HBZ-ID HT013240074
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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    SignaturLeihstatusStandort
    2002 MB 319 bestellbar zur Ausleihe Magazin

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  3. Artikel ; Online: PHARE: a bioinformatics pipeline for compositional profiling of multiclonal Plasmodium falciparum infections from long-read Nanopore sequencing data.

    Hosch, Salome / Wagner, Philipp / Giger, Johanna Nouria / Dubach, Nina / Saavedra, Elis / Perno, Carlo Federico / Gody, Jean-Chrysostome / Pagonendji, Marilou Sonia / Ngoagouni, Carine / Ndoua, Christophe / Nsanzabana, Christian / Vickos, Ulrich / Daubenberger, Claudia / Schindler, Tobias

    The Journal of antimicrobial chemotherapy

    2024  Band 79, Heft 5, Seite(n) 987–996

    Abstract: Background: The emergence of drug-resistant clones of Plasmodium falciparum is a major public health concern, and the ability to detect and track the spread of these clones is crucial for effective malaria control and treatment. However, in endemic ... ...

    Abstract Background: The emergence of drug-resistant clones of Plasmodium falciparum is a major public health concern, and the ability to detect and track the spread of these clones is crucial for effective malaria control and treatment. However, in endemic settings, malaria infected people often carry multiple P. falciparum clones simultaneously making it likely to miss drug-resistant clones using traditional molecular typing methods.
    Objectives: Our goal was to develop a bioinformatics pipeline for compositional profiling in multiclonal P. falciparum samples, sequenced using the Oxford Nanopore Technologies MinION platform.
    Methods: We developed the 'Finding P. falciparum haplotypes with resistance mutations in polyclonal infections' (PHARE) pipeline using existing bioinformatics tools and custom scripts written in python. PHARE was validated on three control datasets containing P. falciparum DNA of four laboratory strains at varying mixing ratios. Additionally, the pipeline was tested on clinical samples from children admitted to a paediatric hospital in the Central African Republic.
    Results: The PHARE pipeline achieved high recall and accuracy rates in all control datasets. The pipeline can be used on any gene and was tested with amplicons of the P. falciparum drug resistance marker genes pfdhps, pfdhfr and pfK13.
    Conclusions: The PHARE pipeline helps to provide a more complete picture of drug resistance in the circulating P. falciparum population and can help to guide treatment recommendations. PHARE is freely available under the GNU Lesser General Public License v.3.0 on GitHub: https://github.com/Fippu/PHARE.
    Mesh-Begriff(e) Plasmodium falciparum/genetics ; Plasmodium falciparum/drug effects ; Humans ; Computational Biology/methods ; Nanopore Sequencing/methods ; Malaria, Falciparum/parasitology ; Drug Resistance/genetics ; Antimalarials/pharmacology ; Mutation
    Chemische Substanzen Antimalarials
    Sprache Englisch
    Erscheinungsdatum 2024-03-19
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 191709-2
    ISSN 1460-2091 ; 0305-7453
    ISSN (online) 1460-2091
    ISSN 0305-7453
    DOI 10.1093/jac/dkae060
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1197: Hefte anzeigen Standort:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 124: Hefte anzeigen

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  4. Artikel: Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation

    Keller, Ladina / Patel, Chandni / Welsche, Sophie / Schindler, Tobias / Hürlimann, Eveline / Keiser, Jennifer

    Parasites & vectors. 2020 Dec., v. 13, no. 1

    2020  

    Abstract: BACKGROUND: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy ... ...

    Abstract BACKGROUND: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy comparing traditional microscopic to newly emerging molecular approaches such as quantitative Polymerase Chain Reaction (qPCR) are scarce and hampered partly by lack of an established diagnostic gold standard. METHODS: We compared the performance of the copromicroscopic Kato-Katz method to qPCR in the framework of a randomized controlled trial on Pemba Island, Tanzania, evaluating treatment efficacy based on cure rates of albendazole monotherapy versus ivermectin-albendazole against Trichuris trichiura and concomitant STH infections. Day-to-day variability of both diagnostic methods was assessed to elucidate reproducibility of test results by analysing two stool samples before and two stool samples after treatment of 160 T. trichiura Kato-Katz positive participants, partially co-infected with Ascaris lumbricoides and hookworm, per treatment arm (n = 320). As negative controls, two faecal samples of 180 Kato-Katz helminth negative participants were analysed. RESULTS: Fair to moderate correlation between microscopic egg count and DNA copy number for the different STH species was observed at baseline and follow-up. Results indicated higher sensitivity of qPCR for all three STH species across all time points; however, we found lower test result reproducibility compared to Kato-Katz. When assessed with two samples from consecutive days by qPCR, cure rates were significantly lower for T. trichiura (23.2 vs 46.8%), A. lumbricoides (75.3 vs 100%) and hookworm (52.4 vs 78.3%) in the ivermectin-albendazole treatment arm, when compared to Kato-Katz. CONCLUSIONS: qPCR diagnosis showed lower reproducibility of test results compared to Kato-Katz, hence multiple samples per participant should be analysed to achieve a reliable diagnosis of STH infection. Our study confirms that cure rates are overestimated using Kato-Katz alone. Our findings emphasize that standardized and accurate molecular diagnostic tools are urgently needed for future monitoring within STH control and/or elimination programmes.
    Schlagwörter Ascaris lumbricoides ; DNA ; Trichuris trichiura ; albendazole ; eggs ; helminthiasis ; hookworms ; mixed infection ; quantitative polymerase chain reaction ; randomized clinical trials ; Tanzania
    Sprache Englisch
    Erscheinungsverlauf 2020-12
    Umfang p. 517.
    Erscheinungsort BioMed Central
    Dokumenttyp Artikel
    Anmerkung NAL-light
    ZDB-ID 2409480-8
    ISSN 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-020-04401-x
    Datenquelle NAL Katalog (AGRICOLA)

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  5. Artikel: Aerobic oxygenation of α-methylene ketones under visible-light catalysed by a CeNi₃ complex with a macrocyclic tris(salen)-ligand

    Nagae, Haruki / Sakamoto, Kazutaka / Fujiwara, Sakiko / Schindler, Tobias / Kon, Yoshihiro / Sato, Kazuhiko / Okuda, Jun / Mashima, Kazushi

    Chemical communications. 2021 Oct. 26, v. 57, no. 85

    2021  

    Abstract: A hetero-tetranuclear CeNi₃ complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis ... ...

    Abstract A hetero-tetranuclear CeNi₃ complex with a macrocyclic ligand catalysed the aerobic oxygenation of a methylene group adjacent to a carbonyl group under visible-light radiation to produce the corresponding α-diketones. The visible-light induced homolysis of the Ce–O bond of a bis(enolate) intermediate is proposed prior to aerobic oxygenation.
    Schlagwörter homolytic cleavage ; ligands ; light
    Sprache Englisch
    Erscheinungsverlauf 2021-1026
    Umfang p. 11169-11172.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 1472881-3
    ISSN 1364-548X ; 1359-7345 ; 0009-241X
    ISSN (online) 1364-548X
    ISSN 1359-7345 ; 0009-241X
    DOI 10.1039/d1cc04540g
    Datenquelle NAL Katalog (AGRICOLA)

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  6. Artikel ; Online: Gene Coverage Count and Classification (GC

    Stabler, Thomas C / Dwivedi, Ankit / Shrestha, Biraj / Joshi, Sudhaunshu / Schindler, Tobias / Ouattara, Amed / García, Guillermo A / Daubenberger, Claudia / Silva, Joana C

    Malaria journal

    2022  Band 21, Heft 1, Seite(n) 357

    Abstract: Background: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly ... ...

    Abstract Background: The ability of malaria rapid diagnostic tests (RDTs) to effectively detect active infections is being compromised by the presence of malaria strains with genomic deletions at the hrp2 and hrp3 loci, encoding the antigens most commonly targeted in diagnostics for Plasmodium falciparum detection. The presence of such deletions can be determined in publically available P. falciparum whole genome sequencing (WGS) datasets. A computational approach was developed and validated, termed Gene Coverage Count and Classification (GC
    Methods: GC
    Results: GC
    Conclusions: The GC
    Mesh-Begriff(e) Histidine ; Plasmodium falciparum/genetics ; Tool Use Behavior ; Whole Genome Sequencing ; Genotype
    Chemische Substanzen Histidine (4QD397987E)
    Sprache Englisch
    Erscheinungsdatum 2022-11-29
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2091229-8
    ISSN 1475-2875 ; 1475-2875
    ISSN (online) 1475-2875
    ISSN 1475-2875
    DOI 10.1186/s12936-022-04376-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel: Prevalence and molecular identification of zoonotic Anisakis and Pseudoterranova species in fish destined to human consumption in Chile

    Muñoz-Caro, Tamara / Machuca, Alvaro / Morales, Pamela / Verdugo, Javiera / Reyes, Rodrigo / García, Macarena / Rutaihwa, Liliana / Schindler, Tobias / Poppert, Sven / Taubert, Anja / Hermosilla, Carlos

    Parasitology research. 2022 May, v. 121, no. 5

    2022  

    Abstract: Zoonotic larvae of the family Anisakidae found in several fish species represent a serious risk in public health since they may cause food-borne anisakidosis in humans. Chile has culinary preferences including eating raw fish in many traditional ... ...

    Abstract Zoonotic larvae of the family Anisakidae found in several fish species represent a serious risk in public health since they may cause food-borne anisakidosis in humans. Chile has culinary preferences including eating raw fish in many traditional preparations. In the present study, a total of 180 fish specimens representing three different fish species, i.e., Chilean hake (Merluccius gayi), snoek (Thyrsites atun), and sea bream (Brama australis), were caught at central coast of Chile. Parasitological examination was performed on musculature and abdominal cavity for subsequent extraction and quantification of anisakid larvae. Estimation of infection parameters, such as prevalence, was performed indicating 100% (CI: 0.94–1.0) prevalence of anisakid L3 in Chilean hakes and snoeks. Moreover, sea breams reached a prevalence of 35% (CI: 0.23–0.48). Prevalence of anisakid larvae in muscle was also analyzed showing values of 18.6% (CI: 0.097–0.309) in Chilean hakes, 15% (CI: 0.07–0.26) in snoeks, and 1.7% (CI: 0–0.089) in sea breams. Meanwhile, prevalence of anisakid larvae in internal organs showed highest values for peritoneum (100% and 83.3%) for snoeks and Chilean hakes, respectively, for liver (96.7%) and gonads (86.6%) in Chilean hakes, and for intestine (98.3%) in snoeks. Molecular analysis of collected anisakid L3 unveiled presence of two potentially zoonotic nematode species, i.e., Pseudoterranova cattani and Anisakis pegreffii. P. cattani was found in Chilean hakes and snoeks being the first molecular host species report for Chilean snoeks. Besides, A. pegreffii was also identified in these species being the first molecular report on this regard. These findings are relevant for better understanding of epidemiology of anisakiasis in Chilean coasts and for public health issues considering potential risk of human population due to its culinary preferences in eating raw fish.
    Schlagwörter Anisakis pegreffii ; Brama ; Merluccius gayi ; Pseudoterranova ; Sparidae ; Thyrsites atun ; abdominal cavity ; anisakiasis ; coasts ; epidemiology ; hosts ; human population ; humans ; intestines ; liver ; muscles ; parasitology ; peritoneum ; public health ; raw fish ; research ; risk ; Chile
    Sprache Englisch
    Erscheinungsverlauf 2022-05
    Umfang p. 1295-1304.
    Erscheinungsort Springer Berlin Heidelberg
    Dokumenttyp Artikel
    ZDB-ID 284966-5
    ISSN 1432-1955 ; 0932-0113 ; 0044-3255
    ISSN (online) 1432-1955
    ISSN 0932-0113 ; 0044-3255
    DOI 10.1007/s00436-022-07459-x
    Datenquelle NAL Katalog (AGRICOLA)

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  8. Artikel ; Online: Draft Genome Sequences of Seven Streptococcus agalactiae Strains Isolated from Camelus dromedarius at the Horn of Africa

    Rothen, Julian / Schindler, Tobias / Pothier, Joël F. / Younan, Mario / Certa, Ulrich / Daubenberger, Claudia A. / Pflüger, Valentin / Jores, Joerg

    Genome Announcements

    2023  

    Abstract: We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS) pangenome and might provide more insight into the ... ...

    Abstract We present draft whole-genome sequences of seven Streptococcus agalactiae strains isolated from Camelus dromedarius in Kenya and Somalia. These data are an extension to the group B Streptococcus (GBS) pangenome and might provide more insight into the underlying mechanisms of pathogenicity and antibiotic resistance of camel GBS.
    Schlagwörter africa ; strains ; camelus dromedarius ; streptococcus
    Erscheinungsdatum 2023-03-10T14:33:15Z
    Verlag American Society for Microbiology
    Erscheinungsland fr
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  9. Artikel ; Online: Performance of the Kato-Katz method and real time polymerase chain reaction for the diagnosis of soil-transmitted helminthiasis in the framework of a randomised controlled trial: treatment efficacy and day-to-day variation.

    Keller, Ladina / Patel, Chandni / Welsche, Sophie / Schindler, Tobias / Hürlimann, Eveline / Keiser, Jennifer

    Parasites & vectors

    2020  Band 13, Heft 1, Seite(n) 517

    Abstract: Background: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy ... ...

    Abstract Background: Accurate, scalable and sensitive diagnostic tools are crucial in determining prevalence of soil-transmitted helminths (STH), assessing infection intensities and monitoring treatment efficacy. However, assessments on treatment efficacy comparing traditional microscopic to newly emerging molecular approaches such as quantitative Polymerase Chain Reaction (qPCR) are scarce and hampered partly by lack of an established diagnostic gold standard.
    Methods: We compared the performance of the copromicroscopic Kato-Katz method to qPCR in the framework of a randomized controlled trial on Pemba Island, Tanzania, evaluating treatment efficacy based on cure rates of albendazole monotherapy versus ivermectin-albendazole against Trichuris trichiura and concomitant STH infections. Day-to-day variability of both diagnostic methods was assessed to elucidate reproducibility of test results by analysing two stool samples before and two stool samples after treatment of 160 T. trichiura Kato-Katz positive participants, partially co-infected with Ascaris lumbricoides and hookworm, per treatment arm (n = 320). As negative controls, two faecal samples of 180 Kato-Katz helminth negative participants were analysed.
    Results: Fair to moderate correlation between microscopic egg count and DNA copy number for the different STH species was observed at baseline and follow-up. Results indicated higher sensitivity of qPCR for all three STH species across all time points; however, we found lower test result reproducibility compared to Kato-Katz. When assessed with two samples from consecutive days by qPCR, cure rates were significantly lower for T. trichiura (23.2 vs 46.8%), A. lumbricoides (75.3 vs 100%) and hookworm (52.4 vs 78.3%) in the ivermectin-albendazole treatment arm, when compared to Kato-Katz.
    Conclusions: qPCR diagnosis showed lower reproducibility of test results compared to Kato-Katz, hence multiple samples per participant should be analysed to achieve a reliable diagnosis of STH infection. Our study confirms that cure rates are overestimated using Kato-Katz alone. Our findings emphasize that standardized and accurate molecular diagnostic tools are urgently needed for future monitoring within STH control and/or elimination programmes.
    Mesh-Begriff(e) Animals ; Albendazole/therapeutic use ; Anthelmintics/therapeutic use ; Ascaris lumbricoides/isolation & purification ; Clinical Laboratory Techniques/methods ; Drug Combinations ; Feces/parasitology ; Helminthiasis/diagnosis ; Helminthiasis/drug therapy ; Helminths/isolation & purification ; Indian Ocean Islands/epidemiology ; Ivermectin/therapeutic use ; Parasite Egg Count/methods ; Pathology, Molecular/methods ; Prevalence ; Real-Time Polymerase Chain Reaction ; Reproducibility of Results ; Sensitivity and Specificity ; Soil/parasitology ; Tanzania/epidemiology ; Treatment Outcome ; Trichuris/isolation & purification ; Humans
    Chemische Substanzen Albendazole (F4216019LN) ; Anthelmintics ; Drug Combinations ; Ivermectin (70288-86-7) ; Soil
    Sprache Englisch
    Erscheinungsdatum 2020-10-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Randomized Controlled Trial
    ZDB-ID 2409480-8
    ISSN 1756-3305 ; 1756-3305
    ISSN (online) 1756-3305
    ISSN 1756-3305
    DOI 10.1186/s13071-020-04401-x
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Evaluation of Pd→B Interactions in Diphosphinoborane Complexes and Impact on Inner-Sphere Reductive Elimination.

    Ritter, Florian / John, Lukas / Schindler, Tobias / Schroers, Julian P / Teeuwen, Simon / Tauchert, Michael E

    Chemistry (Weinheim an der Bergstrasse, Germany)

    2020  Band 26, Heft 59, Seite(n) 13436–13444

    Abstract: The dative Pd→B interaction in a series ... ...

    Abstract The dative Pd→B interaction in a series of
    Sprache Englisch
    Erscheinungsdatum 2020-09-18
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1478547-X
    ISSN 1521-3765 ; 0947-6539
    ISSN (online) 1521-3765
    ISSN 0947-6539
    DOI 10.1002/chem.202001189
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