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  1. AU="Schneider, Gunter"
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  1. Buch: Magnetic resonance angiography

    Schneider, Günter

    techniques, indications and practical applications

    2005  

    Verfasserangabe G. Schneider ... (ed.)
    Sprache Deutsch
    Umfang X, 356 S. : Ill., graph. Darst.
    Verlag Springer
    Erscheinungsort Milan u.a.
    Erscheinungsland Italien
    Dokumenttyp Buch
    HBZ-ID HT014411127
    ISBN 88-470-0266-4 ; 978-88-470-0266-1
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: A Hypoxia-Epigenetics Axis Drives EMT in Pancreatic Cancer.

    Wirth, Matthias / Schneider, Günter

    Cancer research

    2024  Band 84, Heft 11, Seite(n) 1739–1741

    Abstract: Epithelial-to-mesenchymal transition (EMT) is a classical cellular plasticity process induced by various cell-intrinsic and -extrinsic triggers. Although prominent factors, such as TGFβ, mediate EMT via well-characterized pathways, alternative avenues ... ...

    Abstract Epithelial-to-mesenchymal transition (EMT) is a classical cellular plasticity process induced by various cell-intrinsic and -extrinsic triggers. Although prominent factors, such as TGFβ, mediate EMT via well-characterized pathways, alternative avenues are less well understood. Transcriptomic subtyping of pancreatic ductal adenocarcinoma (PDAC) has demonstrated that basal-like PDACs enrich a mesenchymal-like expression program, emphasizing the relevance of EMT in the disease. In this issue of Cancer Research, Brown and colleagues demonstrate the tight connection of EMT to hypoxia. Through a detailed mechanistic analysis, the authors deciphered that hypoxia-induced signals are integrated by the histone H3 lysine 36 di-methylation (H3K36me2) mark. On the one hand, hypoxia decreased activity of the H3K36me2 eraser KDM2A, while on the other hand promoting stabilization of the H3K36me2 writer NSD2. Hypoxia diminished the expression of a set of serine-threonine phosphatases, subsequently resulting in SRC kinase family-dependent activation of canonical MEK, ERK, and JNK signaling to impinge on NSD2 expression. In addition, reduced expression of the protein phosphatase PP2Cδ was linked to increased NSD2 protein expression. These discoveries illuminate the close relationship of hypoxia signaling to the epigenetic machinery and cellular plasticity processes. See related article by Brown et al., p. 1764.
    Mesh-Begriff(e) Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/metabolism ; Epithelial-Mesenchymal Transition/genetics ; Epigenesis, Genetic ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Carcinoma, Pancreatic Ductal/metabolism ; Histones/metabolism ; Histones/genetics ; Gene Expression Regulation, Neoplastic
    Chemische Substanzen Histones
    Sprache Englisch
    Erscheinungsdatum 2024-06-04
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-23-3578
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Stress granules-membraneless organelles as therapeutic targets in pancreatic cancer.

    Schneider, Carolin / Schneider, Günter

    EMBO molecular medicine

    2024  Band 16, Heft 3, Seite(n) 429–431

    Mesh-Begriff(e) Humans ; Biomolecular Condensates ; Stress Granules ; Pancreatic Neoplasms/therapy ; Cytoplasmic Granules
    Sprache Englisch
    Erscheinungsdatum 2024-02-27
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2467145-9
    ISSN 1757-4684 ; 1757-4676
    ISSN (online) 1757-4684
    ISSN 1757-4676
    DOI 10.1038/s44321-024-00040-2
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Buch ; Dissertation / Habilitation: Funktionelle Interferenz zwischen HMG-I(Y)- und NF-AT-Faktoren bei der Promoterinduktion des Interleukin-4-Gens

    Schneider, Günter

    2002  

    Verfasserangabe vorgelegt von Günter Schneider
    Sprache Deutsch
    Umfang 114 S., Ill., graph. Darst., 21 cm
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Würzburg, Univ., Diss., 2003
    HBZ-ID HT013799693
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Artikel ; Online: Single-cell profiling guided combination therapy of c-Fos and histone deacetylase inhibitors in diffuse large B-cell lymphoma.

    Krämer, Oliver H / Schneider, Günter

    Clinical and translational medicine

    2022  Band 12, Heft 5, Seite(n) e858

    Abstract: In this commentary on Wang, Wu, Xia, and colleagues, Clinical Translational Medicine, 2022, we sum up and discuss recent evidence on the regulation and relevance of the transcription factor c-FOS in diffuse large B cell lymphoma cells that are treated ... ...

    Abstract In this commentary on Wang, Wu, Xia, and colleagues, Clinical Translational Medicine, 2022, we sum up and discuss recent evidence on the regulation and relevance of the transcription factor c-FOS in diffuse large B cell lymphoma cells that are treated with epigenetic erasers of the histone deacetylase inhibitor family.
    Mesh-Begriff(e) Cell Line, Tumor ; Gene Expression Regulation, Neoplastic ; Histone Deacetylase Inhibitors/pharmacology ; Histone Deacetylase Inhibitors/therapeutic use ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Lymphoma, Large B-Cell, Diffuse/pathology ; Protein Processing, Post-Translational
    Chemische Substanzen Histone Deacetylase Inhibitors
    Sprache Englisch
    Erscheinungsdatum 2022-05-23
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 2697013-2
    ISSN 2001-1326 ; 2001-1326
    ISSN (online) 2001-1326
    ISSN 2001-1326
    DOI 10.1002/ctm2.858
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting.

    Hessmann, Elisabeth / Schneider, Günter

    Gastroenterology

    2021  Band 161, Heft 3, Seite(n) 785–791

    Abstract: Pancreatic ductal adenocarcinoma remains a major challenge in cancer medicine. Given the increase in incidence and mortality, interdisciplinary research is necessary to translate basic knowledge into therapeutic strategies improving the outcome of ... ...

    Abstract Pancreatic ductal adenocarcinoma remains a major challenge in cancer medicine. Given the increase in incidence and mortality, interdisciplinary research is necessary to translate basic knowledge into therapeutic strategies improving the outcome of patients. On the 4
    Mesh-Begriff(e) Animals ; Biomarkers, Tumor/genetics ; Biomedical Research/trends ; COVID-19 ; Cell Lineage ; Diffusion of Innovation ; Genetic Predisposition to Disease ; Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/mortality ; Pancreatic Neoplasms/pathology ; Pancreatic Neoplasms/therapy ; Tumor Microenvironment ; Videoconferencing
    Chemische Substanzen Biomarkers, Tumor
    Sprache Englisch
    Erscheinungsdatum 2021-06-02
    Erscheinungsland United States
    Dokumenttyp Congress ; Research Support, Non-U.S. Gov't
    ZDB-ID 80112-4
    ISSN 1528-0012 ; 0016-5085
    ISSN (online) 1528-0012
    ISSN 0016-5085
    DOI 10.1053/j.gastro.2021.04.082
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Epigenetic control of pancreatic cancer metastasis.

    Krauß, Lukas / Schneider, Carolin / Hessmann, Elisabeth / Saur, Dieter / Schneider, Günter

    Cancer metastasis reviews

    2023  Band 42, Heft 4, Seite(n) 1113–1131

    Abstract: Surgical resection, when combined with chemotherapy, has been shown to significantly improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC). However, this treatment option is only feasible for a fraction of patients, as more ... ...

    Abstract Surgical resection, when combined with chemotherapy, has been shown to significantly improve the survival rate of patients with pancreatic ductal adenocarcinoma (PDAC). However, this treatment option is only feasible for a fraction of patients, as more than 50% of cases are diagnosed with metastasis. The multifaceted process of metastasis is still not fully understood, but recent data suggest that transcriptional and epigenetic plasticity play significant roles. Interfering with epigenetic reprogramming can potentially control the adaptive processes responsible for metastatic progression and therapy resistance, thereby enhancing treatment responses and preventing recurrence. This review will focus on the relevance of histone-modifying enzymes in pancreatic cancer, specifically on their impact on the metastatic cascade. Additionally, it will also provide a brief update on the current clinical developments in epigenetic therapies.
    Mesh-Begriff(e) Humans ; Pancreatic Neoplasms/genetics ; Pancreatic Neoplasms/pathology ; Carcinoma, Pancreatic Ductal/genetics ; Carcinoma, Pancreatic Ductal/pathology ; Epigenesis, Genetic
    Sprache Englisch
    Erscheinungsdatum 2023-09-02
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-023-10132-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch ; Online ; Dissertation / Habilitation: Synthetic lethalities to target a MYC-driven PDAC subtype

    Lankes, Katharina Verfasser] / [Schneider, Günter [Akademischer Betreuer] / Feige, Matthias Gutachter] / [Schneider, Günter [Gutachter]

    2023  

    Verfasserangabe Katharina Lankes ; Gutachter: Matthias Feige, Günter Schneider ; Betreuer: Günter Schneider
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Englisch
    Verlag Universitätsbibliothek der TU München
    Erscheinungsort München
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  9. Buch ; Online ; Dissertation / Habilitation: Screening of a drug library in HDAC-2 proficient and deficient murine pancreatic ductal adenocarcinoma cells to identify new potential combination therapies

    Kidess, Marc Anwar [Verfasser] / Schneider, Günter [Akademischer Betreuer] / Multhoff, Gabriele [Gutachter] / Schneider, Günter [Gutachter]

    2023  

    Verfasserangabe Marc Anwar Kidess ; Gutachter: Gabriele Multhoff, Günter Schneider ; Betreuer: Günter Schneider
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Englisch
    Verlag Universitätsbibliothek der TU München
    Erscheinungsort München
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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  10. Buch ; Online ; Dissertation / Habilitation: The Role of FRA1 and SUMOylation in Pancreatic Cancer

    Schneeweis, Christian Andreas Verfasser] / Schneider, Günter [Akademischer Betreuer] / [Küster, Bernhard [Gutachter] / Schneider, Günter [Gutachter]

    2023  

    Verfasserangabe Christian Andreas Schneeweis ; Gutachter: Bernhard Küster, Günter Schneider ; Betreuer: Günter Schneider
    Schlagwörter Medizin, Gesundheit ; Medicine, Health
    Thema/Rubrik (Code) sg610
    Sprache Englisch
    Verlag Universitätsbibliothek der TU München
    Erscheinungsort München
    Dokumenttyp Buch ; Online ; Dissertation / Habilitation
    Datenquelle Digitale Dissertationen im Internet

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