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  1. Book: Trends in Qualitätskontrolle, Normung und Analytik von PCDD/F

    Schramm, Karl-Werner

    (GSF-Bericht ; [20]02,09)

    2002  

    Author's details K.-W. Schramm. GSF-Forschungszentrum für Umwelt und Gesundheit in der Helmholtz-Gemeinschaft
    Series title GSF-Bericht ; [20]02,09
    Collection
    Language German
    Size 43 S., graph. Darst., 30 cm
    Publisher GSF
    Publishing place Neuherberg
    Publishing country Germany
    Document type Book
    Note Literaturverz. S. 37 - 41
    HBZ-ID HT013818060
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2003 A 3399 order for loan Magazin

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  2. Book: Bioindication in natural-like aquatic ecosystems

    Schramm, Karl-Werner / Severin, Gabriele F.

    endocrine disruptors in outdoor microcosms ; Status-Report

    (GSF-Bericht ; [20]02,2)

    2002  

    Institution Institut für Ökologische Chemie
    Author's details Institut für Ökologische Chemie ; GSF- Forschungszentrum für Umwelt und Gesundheit. K.-W. Schramm ; G. F. Severin
    Series title GSF-Bericht ; [20]02,2
    Collection
    Language English
    Size 94 S., Ill., graph. Darst., 30 cm
    Publisher GSF
    Publishing place Neuherberg
    Publishing country Germany
    Document type Book
    Note Literaturangaben
    HBZ-ID HT013472003
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 A 4680 order for loan Magazin

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  3. Article ; Online: Contamination acts as a genotype-dependent barrier to gene flow, causing genetic erosion and fine-grained population subdivision in Mussels from the Strait of Istanbul.

    Theodorakis, Christopher W / Meyer, Mary-Ann / Okay, Oya / Yakan, Sevil Deniz / Schramm, Karl-Werner

    Ecotoxicology (London, England)

    2024  Volume 33, Issue 1, Page(s) 47–65

    Abstract: This study provides evidence of fine-grained genetic structuring in Mediterranean mussels (Mytilus galloprovincialis) from the Strait of Istanbul, caused by barriers to gene flow via contaminant-mediated selection. In this study, mitochondrial D-loop ... ...

    Abstract This study provides evidence of fine-grained genetic structuring in Mediterranean mussels (Mytilus galloprovincialis) from the Strait of Istanbul, caused by barriers to gene flow via contaminant-mediated selection. In this study, mitochondrial D-loop sequences were analyzed in mussels from 8 localities, all less than 30 kilometers apart, with differing contaminant loads. The results were: 1) Intra-population genetic differentiation (Φ
    MeSH term(s) Animals ; Gene Flow ; Bayes Theorem ; Mytilus/genetics ; Haplotypes ; Seafood ; Genetic Variation ; Genetics, Population
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 34042-x
    ISSN 1573-3017 ; 0963-9292
    ISSN (online) 1573-3017
    ISSN 0963-9292
    DOI 10.1007/s10646-023-02725-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 7663: Show issues

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  4. Article ; Online: Analytical aspects of meet-in-metabolite analysis for molecular pathway reconstitution from exposure to adverse outcome.

    Shen, Heqing / Zhang, Yike / Schramm, Karl-Werner

    Molecular aspects of medicine

    2021  Volume 87, Page(s) 101006

    Abstract: To explore the etiology of diseases is one of the major goals in epidemiological study. Meet-in-metabolite analysis reconstitutes biomonitoring-based adverse outcome (AO) pathways from environmental exposure to a disease, in which the chemical exposome- ... ...

    Abstract To explore the etiology of diseases is one of the major goals in epidemiological study. Meet-in-metabolite analysis reconstitutes biomonitoring-based adverse outcome (AO) pathways from environmental exposure to a disease, in which the chemical exposome-related metabolism responses are transmitted to incur the AO-related metabolism phenotypes. However, the ongoing data-dependent acquisition of non-targeted biomonitoring by high-resolution mass spectrometry (HRMS) is biased against the low abundance molecules, which forms the major of molecular internal exposome, i.e., the totality of trace levels of environmental pollutants and/or their metabolites in human samples. The recent development of data-independent acquisition protocols for HRMS screening has opened new opportunities to enhance unbiased measurement of the extremely low abundance molecules, which can encompass a wide range of analytes and has been applied in metabolomics, DNA, and protein adductomics. In addition, computational MS for small molecules is urgently required for the top-down exposome databases. Although a holistic analysis of the exposome and endogenous metabolites is plausible, multiple and flexible strategies, instead of "putting one thing above all" are proposed.
    MeSH term(s) Environmental Exposure/adverse effects ; Humans ; Mass Spectrometry ; Metabolome ; Metabolomics/methods
    Language English
    Publishing date 2021-07-23
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2021.101006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Perinatal effects of persistent organic pollutants on thyroid hormone concentration in placenta and breastmilk.

    De Angelis, Meri / Schramm, Karl-Werner

    Molecular aspects of medicine

    2021  Volume 87, Page(s) 100988

    Abstract: Thyroid hormones (TH) are known to play a critical role in regulating many biological processes including growth and development, energy homeostasis, thermogenesis, lipolysis and metabolism of cholesterol. Severe TH deficiency especially during fetal ... ...

    Abstract Thyroid hormones (TH) are known to play a critical role in regulating many biological processes including growth and development, energy homeostasis, thermogenesis, lipolysis and metabolism of cholesterol. Severe TH deficiency especially during fetal development results in cretinism, but can also lead to an imbalance in metabolism with, among others, an alteration in body weight composition. Over the past two decades, increasing evidence has shown that certain persistent organic pollutants (POP) can interfere with the endocrine system. These POP referred to as "endocrine disrupting chemicals" are widely present in the environment and populations are exposed globally. Moreover, epidemiological studies have shown that a particularly sensitive period is the pre- and postnatal time. Indeed, perinatal exposure to such chemicals could lead to the onset diseases in later life. It is known, that, maternal thyroid hormones are transported by the placenta to the fetus from 6 weeks of gestation and it seems that during the first trimester, and part of the second, the fetus is entirely dependent on maternal TH supply for its development. Interferences in the TH-network as a consequence of the exposure to such pollutants could cause variations in TH concentration. Only small changes in maternal thyroid hormone levels in early stages of pregnancy can influence fetal neurological and cardiovascular development, as well as according to recent studies, have effect on childhood body composition. With this review, we will report the most recent and important studies concerning the association between thyroid hormone concentration and POP levels measured during the perinatal period. We will mostly focus on the data recently reported on placenta and breastmilk as main sources for understanding the potential consequences of exposure. The possible link between exposure to pollutants, TH dysregulation and possible adverse outcome will also be briefly discussed. From our literature search, several studies support the hypothesis that pre- and postnatal exposure to different pollutants might play a role in causing variation in thyroid hormone concentration. However, few research papers have so far studied the relationship linking exposure to pollutants, TH concentration and possible health consequences. Therefore, this review highlights the need for further research in this direction.
    MeSH term(s) Child ; Environmental Pollutants/analysis ; Environmental Pollutants/metabolism ; Environmental Pollutants/toxicity ; Female ; Humans ; Milk, Human/chemistry ; Milk, Human/metabolism ; Persistent Organic Pollutants ; Placenta/metabolism ; Pregnancy ; Thyroid Hormones/metabolism
    Chemical Substances Environmental Pollutants ; Thyroid Hormones
    Language English
    Publishing date 2021-07-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2021.100988
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1189: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Green Chemistry: Some important forerunners and current issues

    Lenoir, Dieter / Schramm, Karl-Werner / Lalah, Joseph O

    Sustainable chemistry and pharmacy. 2020 Dec., v. 18

    2020  

    Abstract: In this essay some important forerunners of green chemistry will be discussed and compared with the present state. The relationship to ethics will be considered. Starting from the new movement of green chemistry by Anastas, some important highlights will ...

    Abstract In this essay some important forerunners of green chemistry will be discussed and compared with the present state. The relationship to ethics will be considered. Starting from the new movement of green chemistry by Anastas, some important highlights will be presented. The new activities of IUPAC and other institutions on the concepts of metrics for green syntheses will be discussed. The prime importance of the inclusion of developing African countries into the concepts will also be covered. Green chemistry philosophy has become part of sustainable chemistry which emphasizes the implementation of the concept of sustainability in the production and use of chemicals and chemical products for sustainable development and, some sustainable development concepts are included under the section on Africa.
    Keywords ethics ; green chemistry ; sustainable development ; Africa
    Language English
    Dates of publication 2020-12
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 2352-5541
    DOI 10.1016/j.scp.2020.100313
    Database NAL-Catalogue (AGRICOLA)

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  7. Article ; Online: Comment on "Glycine-functionalized copper(ii) hydroxide nanoparticles with high intrinsic superoxide dismutase activity" by K. Korschelt, R. Ragg, C. S. Metzger, M. Kluenker, M. Oster, B. Barton, M. Panthöfer, D. Strand, U. Kolb, M. Mondeshki, S. Strand, J. Brieger, M. N. Tahir and W. Tremel, Nanoscale, 2017, 9, 3952.

    Lenoir, Dieter / Schramm, Karl-Werner

    Nanoscale

    2017  Volume 9, Issue 40, Page(s) 15717–15718

    Abstract: Detoxification of cigarette smoke employing copper compounds has a potential for the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans and should not be practiced before the degree of formation has been shown to be harmless. ...

    Abstract Detoxification of cigarette smoke employing copper compounds has a potential for the formation of polychlorinated dibenzo-p-dioxins and dibenzofurans and should not be practiced before the degree of formation has been shown to be harmless.
    Language English
    Publishing date 2017-10-19
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c7nr04207h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Spatial, temporal, and inter-compartmental environmental monitoring of lipophilic pollutants by virtual organisms

    Pandelova, Marchela / Henkelmann, Bernhard / Lalah, Joseph O / Norf, Helge / Schramm, Karl-Werner

    Chemosphere. 2021 Feb., v. 264

    2021  

    Abstract: Sampling points belonging to the Harz National Park river system, Germany, were selected between the period of 2014 and 2017 for monitoring polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in ... ...

    Abstract Sampling points belonging to the Harz National Park river system, Germany, were selected between the period of 2014 and 2017 for monitoring polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) in water, air, and sediment. Triolein-containing Virtual Organisms (VO) were employed to assess the levels of chemicals in water, air and triolein as surrogate for natural fat. To avoid overestimation of the concentrations 20 performance reference compounds (PRCs)-16 PRCs-PAHs and 4 PRCs-PCBs were covering the range of properties of native compounds. Results manifested the highest concentration of individual PAH as follows: 31 ng fluoranthene/L water, 3600 ng pyrene/g fat, 62 ng phenanthrene/m³ air and 2800 ng fluoranthene/g dw sediment. All PCBs and OCPs values were below above mentioned PAH concentrations and far below EU-limit levels. Environmental partition of chemicals was investigated by calculating fugacity, suggesting a mass transport from water to air. Only quite volatile compounds such as hexachlorobutadiene showed higher fugacity in air. Ratios of sediment/water concentrations and log Kow within individual sampling periods at Holtemme River exhibited strong linear relationships. Interestingly, during summer months of the years water and fat contents well correlate to the flow rates of Holtemme River. Our results show that VO can be successfully used as a tool for ongoing exposure assessment studies and predictions of worst case levels in food and nutrition.
    Keywords air ; exposure assessment ; lipophilicity ; mass transfer ; national parks ; nutrition ; polychlorinated biphenyls ; rivers ; sediments ; summer ; triolein ; Germany
    Language English
    Dates of publication 2021-02
    Publishing place Elsevier Ltd
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 120089-6
    ISSN 1879-1298 ; 0045-6535 ; 0366-7111
    ISSN (online) 1879-1298
    ISSN 0045-6535 ; 0366-7111
    DOI 10.1016/j.chemosphere.2020.128546
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Book ; Online ; Thesis: Thyroid Hormone Determination and Associations with Environmental Exposure and Gestational Diabetes Mellitus

    Li, Zhongmin [Verfasser] / Schramm, Karl-Werner [Akademischer Betreuer] / Schramm, Karl-Werner [Gutachter] / Klingenspor, Martin [Gutachter]

    2020  

    Author's details Zhongmin Li ; Gutachter: Karl-Werner Schramm, Martin Klingenspor ; Betreuer: Karl-Werner Schramm
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  10. Book ; Online ; Thesis: Method development and application for the analysis of hydro- and lipophilic hormones and neurotransmitters in murine tissues

    Nagler, Joachim [Verfasser] / Schramm, Karl-Werner [Akademischer Betreuer] / Grunwald Kadow, Ilona [Gutachter] / Schramm, Karl-Werner [Gutachter]

    2020  

    Author's details Joachim Nagler ; Gutachter: Ilona Grunwald Kadow, Karl-Werner Schramm ; Betreuer: Karl-Werner Schramm
    Keywords Biowissenschaften, Biologie ; Life Science, Biology
    Subject code sg570
    Language English
    Publisher Universitätsbibliothek der TU München
    Publishing place München
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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