LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 16

Search options

  1. Article ; Online: Acquisition of Host Cytosolic Protein by Toxoplasma gondii Bradyzoites.

    Kannan, Geetha / Thaprawat, Pariyamon / Schultz, Tracey L / Carruthers, Vern B

    mSphere

    2021  Volume 6, Issue 1

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    MeSH term(s) Animals ; CHO Cells ; Cricetulus ; Cytosol/metabolism ; Doxycycline/pharmacology ; Host-Parasite Interactions ; Luminescent Proteins/metabolism ; Male ; Mice ; Mice, Inbred CBA ; Toxoplasma/metabolism ; Red Fluorescent Protein
    Chemical Substances Luminescent Proteins ; Doxycycline (N12000U13O)
    Language English
    Publishing date 2021-01-27
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/mSphere.00934-20
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  2. Article: A

    Piro, Federica / Masci, Silvia / Kannan, Geetha / Focaia, Riccardo / Schultz, Tracey L / Carruthers, Vern B / Di Cristina, Manlio

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Toxoplasma gondii: Importance: T. ... ...

    Abstract Toxoplasma gondii
    Importance: T. gondii
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.08.31.555807
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  3. Article ; Online: A

    Piro, Federica / Masci, Silvia / Kannan, Geetha / Focaia, Riccardo / Schultz, Tracey L / Thaprawat, Pariyamon / Carruthers, Vern B / Di Cristina, Manlio

    mSphere

    2023  Volume 9, Issue 1, Page(s) e0059723

    Abstract: Toxoplasma ... ...

    Abstract Toxoplasma gondii
    MeSH term(s) Animals ; Humans ; Toxoplasma/metabolism ; Parasites ; Vacuoles/metabolism ; Amino Acid Transport Systems/metabolism ; Arginine/metabolism
    Chemical Substances Amino Acid Transport Systems ; Arginine (94ZLA3W45F)
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ISSN 2379-5042
    ISSN (online) 2379-5042
    DOI 10.1128/msphere.00597-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  4. Article: Non-canonical activation of IRE1α during

    McFadden, Michael J / Reynolds, Mack B / Michmerhuizen, Britton C / Ólafsson, Einar B / Anderson, Faith M / Schultz, Tracey L / O'Riordan, Mary X D / O'Meara, Teresa R

    bioRxiv : the preprint server for biology

    2024  

    Abstract: While the canonical function of IRE1α is to detect misfolded proteins and activate the unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can also activate IRE1α, which modulates innate immunity and infection outcomes. ... ...

    Abstract While the canonical function of IRE1α is to detect misfolded proteins and activate the unfolded protein response (UPR) to maintain cellular homeostasis, microbial pathogens can also activate IRE1α, which modulates innate immunity and infection outcomes. However, how infection activates IRE1α and its associated inflammatory functions have not been fully elucidated. Recognition of microbe-associated molecular patterns can activate IRE1α, but it is unclear whether this depends on protein misfolding. Here, we report that a common and deadly fungal pathogen,
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.10.02.560560
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  5. Article: Translation initiation factor eIF1.2 promotes

    Wang, Fengrong / Holmes, Michael J / Hong, Hea Jin / Thaprawat, Pariyamon / Kannan, Geetha / Huynh, My-Hang / Schultz, Tracey L / Licon, M Haley / Lourido, Sebastian / Dong, Wenzhao / Querido, Jailson Brito / Sullivan, William J / O'Leary, Seán E / Carruthers, Vern B

    bioRxiv : the preprint server for biology

    2024  

    Abstract: ... The ... ...

    Abstract The parasite
    Language English
    Publishing date 2024-05-15
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.11.03.565545
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Inter-library loan at ZB MED

    Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

  6. Article ; Online: Translation initiation factor eIF1.2 promotes Toxoplasma stage conversion by regulating levels of key differentiation factors.

    Wang, Fengrong / Holmes, Michael J / Hong, Hea Jin / Thaprawat, Pariyamon / Kannan, Geetha / Huynh, My-Hang / Schultz, Tracey L / Licon, M Haley / Lourido, Sebastian / Dong, Wenzhao / Brito Querido, Jailson / Sullivan, William J / O'Leary, Seán E / Carruthers, Vern B

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 4385

    Abstract: The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a mutagenesis ... ...

    Abstract The parasite Toxoplasma gondii persists in its hosts by converting from replicating tachyzoites to latent bradyzoites housed in tissue cysts. The molecular mechanisms that mediate T. gondii differentiation remain poorly understood. Through a mutagenesis screen, we identified translation initiation factor eIF1.2 as a critical factor for T. gondii differentiation. A F97L mutation in eIF1.2 or the genetic ablation of eIF1.2 (∆eif1.2) markedly impeded bradyzoite cyst formation in vitro and in vivo. We demonstrated, at single-molecule level, that the eIF1.2 F97L mutation impacts the scanning process of the ribosome preinitiation complex on a model mRNA. RNA sequencing and ribosome profiling experiments unveiled that ∆eif1.2 parasites are defective in upregulating bradyzoite induction factors BFD1 and BFD2 during stress-induced differentiation. Forced expression of BFD1 or BFD2 significantly restored differentiation in ∆eif1.2 parasites. Together, our findings suggest that eIF1.2 functions by regulating the translation of key differentiation factors necessary to establish chronic toxoplasmosis.
    MeSH term(s) Toxoplasma/metabolism ; Toxoplasma/genetics ; Animals ; Protozoan Proteins/metabolism ; Protozoan Proteins/genetics ; Toxoplasmosis/parasitology ; Toxoplasmosis/metabolism ; Mice ; Mutation ; Ribosomes/metabolism ; Protein Biosynthesis ; Female ; RNA, Messenger/metabolism ; RNA, Messenger/genetics ; Cell Differentiation ; Humans
    Chemical Substances Protozoan Proteins ; RNA, Messenger
    Language English
    Publishing date 2024-05-23
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-48685-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  7. Article ; Online: Mitochondria-Derived Vesicles Deliver Antimicrobial Reactive Oxygen Species to Control Phagosome-Localized Staphylococcus aureus.

    Abuaita, Basel H / Schultz, Tracey L / O'Riordan, Mary X

    Cell host & microbe

    2018  Volume 24, Issue 5, Page(s) 625–636.e5

    Abstract: Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial mechanisms. Although mitochondria-derived antimicrobial effectors like reactive oxygen species (mROS) aid in bacterial killing, it is unclear how these ... ...

    Abstract Pathogenic bacteria taken up into the macrophage phagosome are the target of many anti-microbial mechanisms. Although mitochondria-derived antimicrobial effectors like reactive oxygen species (mROS) aid in bacterial killing, it is unclear how these effectors reach bacteria within the phagosomal lumen. We show here that endoplasmic reticulum stress triggered upon methicillin-resistant Staphylococcus aureus (MRSA) infection induces mROS that are delivered to bacteria-containing phagosomes via mitochondria-derived vesicles (MDVs). The endoplasmic reticulum stress sensor IRE1α induces mROS, specifically hydrogen peroxide (mH
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Anti-Infective Agents/pharmacology ; Drug Delivery Systems/methods ; Endoplasmic Reticulum ; Endoribonucleases/metabolism ; Female ; Hydrogen Peroxide/metabolism ; Hydrogen Peroxide/pharmacology ; Macrophages/microbiology ; Male ; Methicillin-Resistant Staphylococcus aureus/drug effects ; Methicillin-Resistant Staphylococcus aureus/pathogenicity ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microbial Viability ; Mitochondria/metabolism ; NADPH Oxidase 2/genetics ; Oxidation-Reduction ; Phagosomes/microbiology ; Protein Kinases/genetics ; Protein-Serine-Threonine Kinases/metabolism ; Reactive Oxygen Species/pharmacology ; Staphylococcal Infections/drug therapy ; Staphylococcus aureus/drug effects ; Stress, Physiological ; Superoxide Dismutase/metabolism ; Toll-Like Receptors/metabolism ; Ubiquitin-Protein Ligases/genetics
    Chemical Substances Anti-Bacterial Agents ; Anti-Infective Agents ; Reactive Oxygen Species ; Toll-Like Receptors ; Hydrogen Peroxide (BBX060AN9V) ; Superoxide Dismutase (EC 1.15.1.1) ; superoxide dismutase 2 (EC 1.15.1.1) ; Cybb protein, mouse (EC 1.6.3.-) ; NADPH Oxidase 2 (EC 1.6.3.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; parkin protein (EC 2.3.2.27) ; Protein Kinases (EC 2.7.-) ; ERN1 protein, human (EC 2.7.11.1) ; PTEN-induced putative kinase (EC 2.7.11.1) ; Protein-Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
    Language English
    Publishing date 2018-10-25
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2278004-X
    ISSN 1934-6069 ; 1931-3128
    ISSN (online) 1934-6069
    ISSN 1931-3128
    DOI 10.1016/j.chom.2018.10.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.A 6578: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Article ; Online: The IRE1α Stress Signaling Axis Is a Key Regulator of Neutrophil Antimicrobial Effector Function.

    Abuaita, Basel H / Sule, Gautam J / Schultz, Tracey L / Gao, Fushan / Knight, Jason S / O'Riordan, Mary X

    Journal of immunology (Baltimore, Md. : 1950)

    2021  Volume 207, Issue 1, Page(s) 210–220

    Abstract: Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with human inflammatory diseases in which neutrophils are a key immune component. However, the specific ...

    Abstract Activation of the endoplasmic reticulum stress sensor, IRE1α, is required for effective immune responses against bacterial infection and is associated with human inflammatory diseases in which neutrophils are a key immune component. However, the specific role of IRE1α in regulating neutrophil effector function has not been studied. In this study, we show that infection-induced IRE1α activation licenses neutrophil antimicrobial capacity, including IL-1β production, formation of neutrophil extracellular traps (NETs), and methicillin-resistant
    MeSH term(s) Animals ; Endoribonucleases/immunology ; Healthy Volunteers ; Humans ; Interleukin-1beta/biosynthesis ; Methicillin-Resistant Staphylococcus aureus/immunology ; Mice ; Neutrophils/immunology ; Protein Serine-Threonine Kinases/immunology ; Signal Transduction/immunology
    Chemical Substances IL1B protein, human ; Interleukin-1beta ; ERN1 protein, human (EC 2.7.11.1) ; Protein Serine-Threonine Kinases (EC 2.7.11.1) ; Endoribonucleases (EC 3.1.-)
    Language English
    Publishing date 2021-06-18
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 3056-9
    ISSN 1550-6606 ; 0022-1767 ; 1048-3233 ; 1047-7381
    ISSN (online) 1550-6606
    ISSN 0022-1767 ; 1048-3233 ; 1047-7381
    DOI 10.4049/jimmunol.2001321
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.37: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)
    Zs.MG 28: Show issues

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  9. Article ; Online: Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts.

    Smith, David / Kannan, Geetha / Coppens, Isabelle / Wang, Fengrong / Nguyen, Hoa Mai / Cerutti, Aude / Olafsson, Einar B / Rimple, Patrick A / Schultz, Tracey L / Mercado Soto, Nayanna M / Di Cristina, Manlio / Besteiro, Sébastien / Carruthers, Vern B

    eLife

    2021  Volume 10

    Abstract: Many of the world's warm-blooded species are chronically infected ... ...

    Abstract Many of the world's warm-blooded species are chronically infected with
    MeSH term(s) Animals ; Autophagy ; Brain/parasitology ; Brain/pathology ; Cell Line ; Disease Models, Animal ; Female ; Host-Parasite Interactions ; Humans ; Life Cycle Stages ; Membrane Proteins/genetics ; Membrane Proteins/metabolism ; Membrane Proteins/ultrastructure ; Mice, Inbred CBA ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondria/ultrastructure ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism ; Protozoan Proteins/ultrastructure ; Time Factors ; Toxoplasma/genetics ; Toxoplasma/metabolism ; Toxoplasma/pathogenicity ; Toxoplasma/ultrastructure ; Toxoplasmosis, Cerebral/parasitology ; Toxoplasmosis, Cerebral/pathology ; Vacuoles/genetics ; Vacuoles/metabolism ; Vacuoles/ultrastructure ; Virulence ; Mice
    Chemical Substances ATG9 protein, Toxoplasma gondii ; Membrane Proteins ; Protozoan Proteins
    Language English
    Publishing date 2021-04-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.59384
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  10. Article ; Online: Shared Immune and Repair Markers During Experimental Toxoplasma Chronic Brain Infection and Schizophrenia.

    Tomasik, Jakub / Schultz, Tracey L / Kluge, Wolfgang / Yolken, Robert H / Bahn, Sabine / Carruthers, Vern B

    Schizophrenia bulletin

    2016  Volume 42, Issue 2, Page(s) 386–395

    Abstract: Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia. Nevertheless, the exact neuropathological mechanisms linking T gondii infection and schizophrenia remain ... ...

    Abstract Chronic neurologic infection with Toxoplasma gondii is relatively common in humans and is one of the strongest known risk factors for schizophrenia. Nevertheless, the exact neuropathological mechanisms linking T gondii infection and schizophrenia remain unclear. Here we utilize a mouse model of chronic T gondii infection to identify protein biomarkers that are altered in serum and brain samples at 2 time points during chronic infection. Furthermore, we compare the identified biomarkers to those differing between "postmortem" brain samples from 35 schizophrenia patients and 33 healthy controls. Our findings suggest that T gondii infection causes substantial and widespread immune activation indicative of neural damage and reactive tissue repair in the animal model that partly overlaps with changes observed in the brains of schizophrenia patients. The overlapping changes include increases in C-reactive protein (CRP), interleukin-1 beta (IL-1β), interferon gamma (IFNγ), plasminogen activator inhibitor 1 (PAI-1), tissue inhibitor of metalloproteinases 1 (TIMP-1), and vascular cell adhesion molecule 1 (VCAM-1). Potential roles of these factors in the pathogenesis of schizophrenia and toxoplasmosis are discussed. Identifying a defined set of markers shared within the pathophysiological landscape of these diseases could be a key step towards understanding their specific contributions to pathogenesis.
    MeSH term(s) Animals ; Biomarkers/metabolism ; Brain/immunology ; Brain/metabolism ; Chronic Disease ; Disease Models, Animal ; Humans ; Mice ; Schizophrenia/immunology ; Schizophrenia/metabolism ; Toxoplasma/pathogenicity ; Toxoplasmosis, Cerebral/immunology ; Toxoplasmosis, Cerebral/metabolism
    Chemical Substances Biomarkers
    Language English
    Publishing date 2016-03
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 439173-1
    ISSN 1745-1701 ; 0586-7614
    ISSN (online) 1745-1701
    ISSN 0586-7614
    DOI 10.1093/schbul/sbv134
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

    In stock of ZB MED Cologne/Königswinter

    Zs.B 1323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

To top