Artikel ; Online: Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells.
2024 Band 13, Heft 3
Abstract: Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed ... ...
Abstract | Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed mechanisms linking flow-mechanical cues and biochemical signaling remain unclear. Activin receptor-like kinase 1 (ALK1) integrates SS and ALK1-ligand cues in ECs; |
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Mesh-Begriff(e) | Humans ; Endothelial Cells ; Ligands ; Telangiectasia, Hereditary Hemorrhagic/genetics ; Arteriovenous Malformations ; Signal Transduction ; Bone Morphogenetic Proteins |
Chemische Substanzen | Ligands ; BMP10 protein, human ; Bone Morphogenetic Proteins |
Sprache | Englisch |
Erscheinungsdatum | 2024-02-05 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article |
ZDB-ID | 2661518-6 |
ISSN | 2073-4409 ; 2073-4409 |
ISSN (online) | 2073-4409 |
ISSN | 2073-4409 |
DOI | 10.3390/cells13030285 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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