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  1. Buch: Oxford textbook of rheumatoid arthritis

    Scott, David L. / Galloway, James B. / Cope, Andrew P.

    2020  

    Titelvarianten Textbook of rheumatoid arthritis ; Rheumatoid arthritis
    Verfasserangabe edited by David L. Scott, James Galloway, Andrew Cope, Arthur G.Pratt, Vibeke Strand
    Schlagwörter Rheumatoid arthritis
    Sprache Englisch
    Umfang xiii, 556 Seiten, Illustrationen, 28 cm
    Verlag Oxford University Press
    Erscheinungsort Oxford
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT020580433
    ISBN 978-0-19-883143-3 ; 0-19-883143-9
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Buch: Established rheumatoid arthritis

    Scott, David L.

    (Best practice & research : Clinical rheumatology ; 21,5)

    2007  

    Verfasserangabe David L. Scott ..., guest ed
    Serientitel Best practice & research : Clinical rheumatology ; 21,5
    Best practice & research
    Best practice & research ; Clinical rheumatology
    Überordnung Best practice & research
    Best practice & research ; Clinical rheumatology
    Sprache Englisch
    Umfang S. 805 - 967 : Ill., graph. Darst.
    Verlag Elsevier
    Erscheinungsort Oxford
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT015307523
    ISBN 978-0-7020-2956-1 ; 0-7020-2956-4
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  3. Buch: Inflammatory arthritis in clinical practice

    Scott, Ian C. / Galloway, James B. / Scott, David L.

    2015  

    Verfasserangabe Ian C. Scott ; James B. Galloway ; David L. Scott
    Schlagwörter Arthritis, Rheumatoid / drug therapy ; Spondylarthritis / drug therapy ; Inflammation / drug therapy ; Antirheumatic Agents / therapeutic use ; Anti-Inflammatory Agents / therapeutic use ; Arthritis/Chemotherapy ; Arthritis
    Thema/Rubrik (Code) 616.722061
    Sprache Englisch
    Umfang XVIII, 214 S. : Ill., graph. Darst.
    Ausgabenhinweis 2. ed.
    Verlag Springer
    Erscheinungsort London u.a.
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    HBZ-ID HT018615953
    ISBN 978-1-4471-6647-4 ; 9781447166481 ; 1-4471-6647-7 ; 1447166485
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  4. Buch: Inflammatory arthritis in clinical practice

    Scott, David L. / Kingsley, Gabrielle Helen

    2008  

    Verfasserangabe David L. Scott and Gabrielle H. Kingsley
    Schlagwörter Arthritis, Rheumatoid / drug therapy ; Spondylarthritis / drug therapy ; Inflammation / drug therapy ; Antirheumatic Agents / therapeutic use ; Anti-Inflammatory Agents / therapeutic use
    Sprache Englisch
    Umfang IX, 116 S. : Ill., graph. Darst., 21cm
    Verlag Springer
    Erscheinungsort London
    Erscheinungsland Vereinigtes Königreich
    Dokumenttyp Buch
    Anmerkung Includes index. - Originally published as Inflammatory arthritis. S.l.: Current Medicine Group, 2006. - Formerly CIP
    HBZ-ID HT017022729
    ISBN 978-1-84628-932-3 ; 1-84628-932-7 ; 9781846289330 ; 1846289335
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  5. Buch ; Online: Inflammatory Arthritis in Clinical Practice

    Scott, David L. / Kingsley, Gabrielle H.

    2007  

    Verfasserangabe by David L. Scott, Gabrielle H. Kingsley
    Schlagwörter Emergency medicine ; Nursing ; Occupational Therapy ; Rehabilitation ; Rheumatology
    Sprache Englisch
    Verlag Springer-Verlag London Limited
    Erscheinungsort London
    Dokumenttyp Buch ; Online
    HBZ-ID TT050387273
    ISBN 978-1-8462-8932-3 ; 978-1-8462-8933-0 ; 1-8462-8932-7 ; 1-8462-8933-5
    DOI 10.1007/978-1-84628-933-0
    Datenquelle ZB MED Katalog Medizin, Gesundheit, Ernährung, Umwelt, Agrar

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  6. Artikel ; Online: The Effect of Perfusate Temperature on Delayed Graft Function in Deceased Donor Renal Transplantation.

    Sweet, Ashley L / Connelly, Christopher R / Dewey, Elizabeth N / Scott, David L

    Progress in transplantation (Aliso Viejo, Calif.)

    2023  Band 33, Heft 4, Seite(n) 341–347

    Abstract: Introduction: ...

    Abstract Introduction:
    Mesh-Begriff(e) Humans ; Kidney Transplantation/adverse effects ; Temperature ; Delayed Graft Function/etiology ; Retrospective Studies ; Organ Preservation/adverse effects ; Kidney ; Tissue Donors ; Graft Survival
    Sprache Englisch
    Erscheinungsdatum 2023-11-14
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2864264-8
    ISSN 2164-6708 ; 1526-9248
    ISSN (online) 2164-6708
    ISSN 1526-9248
    DOI 10.1177/15269248231212920
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  7. Artikel ; Online: Heterogeneity of treatment responses in rheumatoid arthritis using group based trajectory models: secondary analysis of clinical trial data.

    Ibrahim, Fowzia / Scott, Ian C / Scott, David L / Ayis, Salma Ahmed

    BMC rheumatology

    2023  Band 7, Heft 1, Seite(n) 33

    Abstract: Background: Traditionally rheumatoid arthritis (RA) trials classify patients as responders and non-responders; they ignore the potential range of treatment responses. Group Based Trajectory Models (GBTMs) provide a more refined approach. They identify ... ...

    Abstract Background: Traditionally rheumatoid arthritis (RA) trials classify patients as responders and non-responders; they ignore the potential range of treatment responses. Group Based Trajectory Models (GBTMs) provide a more refined approach. They identify patient subgroups with similar outcome trajectories. We used GBTMs to classify patients into subgroups of varying responses and explore factors associated with different responses to intensive treatment in a secondary analysis of intensive treatment in the TITRATE clinical trial.
    Methods: The TITRATE trial enrolled 335 patients with RA: 168 patients were randomised to receive intensive management, which comprised monthly assessments including measures of the disease activity score for 28 joints (DAS28), treatment escalation when patients were not responding sufficiently and psychosocial support; 163 of these patients completed the trial. We applied GBTMs to monthly DAS28 scores over one year to these patients who had received intensive management. The control group had standard care and were assessed every 6 months; they had too few DAS28 scores for applying GBTMs.
    Results: GBTMs identified three distinct trajectories in the patients receiving intensive management: good (n = 40), moderate (n = 76) and poor (n = 47) responders. Baseline body mass index (BMI), disability, fatigue and depression levels were significantly different between trajectory groups. Few (10%) good responders were obese, compared to 38% of moderate, and 43% of poor responders (P = 0.002). Few (8%) good responders had depression, compared to 14% moderate responders, and 38% poor responders (P < 0.001). The key difference in treatments was using high-cost biologics, used in only 5% of good responders but 30% of moderate and 51% of poor responders (P < 0.001). Most good responders had endpoint remissions and low disability, pain, and fatigue scores; few poor responders achieved any favourable outcomes.
    Conclusion: GBTMs identified three trajectories of disease activity progression in patients receiving intensive management for moderately active RA. Baseline variables like obesity and depression predicted different treatment responses. Few good responders needed biologic drugs; they responded to conventional DMARDs alone. GBTMs have the potential to facilitate precision medicine enabling patient-oriented treatment strategies based on key characteristics.
    Registration: TITRATE Trial ISRCTN 70160382.
    Sprache Englisch
    Erscheinungsdatum 2023-09-25
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2918121-5
    ISSN 2520-1026 ; 2520-1026
    ISSN (online) 2520-1026
    ISSN 2520-1026
    DOI 10.1186/s41927-023-00348-5
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Artikel ; Online: Thromboembolism and Janus Kinase Inhibitors.

    Ibrahim, Fowzia / Scott, David L

    Drug safety

    2020  Band 43, Heft 9, Seite(n) 831–833

    Mesh-Begriff(e) Azetidines ; Humans ; Janus Kinase Inhibitors ; Piperidines ; Purines ; Pyrazoles ; Pyrimidines ; Sulfonamides ; Thromboembolism ; World Health Organization
    Chemische Substanzen Azetidines ; Janus Kinase Inhibitors ; Piperidines ; Purines ; Pyrazoles ; Pyrimidines ; Sulfonamides ; tofacitinib (87LA6FU830) ; baricitinib (ISP4442I3Y)
    Sprache Englisch
    Erscheinungsdatum 2020-07-17
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article ; Comment
    ZDB-ID 1018059-x
    ISSN 1179-1942 ; 0114-5916
    ISSN (online) 1179-1942
    ISSN 0114-5916
    DOI 10.1007/s40264-020-00973-w
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  9. Artikel: Developing new therapeutic approaches for rheumatoid arthritis: the continuing challenges of clinical assessments.

    Scott, David L

    F1000Research

    2016  Band 5

    Abstract: The management of rheumatoid arthritis has changed dramatically over the last three decades. Improvements in clinical assessment have been a key driver of these changes. However, in the last five years, three areas of unresolved uncertainty have ... ...

    Abstract The management of rheumatoid arthritis has changed dramatically over the last three decades. Improvements in clinical assessment have been a key driver of these changes. However, in the last five years, three areas of unresolved uncertainty have dominated specialist thinking in the field. These challenges comprise identifying the optimal management target, determining how best to reach this target by using intensive treatments, and individualising management because not all patients need or respond to identical treatments. The key problem that links each of these areas is balancing different types of evidence and is most readily appreciated in relation to treatment intensity. Giving more intensive therapy improves outcomes but also increases risks and, with biologic treatments, substantially increases drug costs. Specialists and healthcare funders need to agree on how best to rationalise optimal care for patients with what is most effective and safe and what is affordable.
    Sprache Englisch
    Erscheinungsdatum 2016
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 2699932-8
    ISSN 2046-1402
    ISSN 2046-1402
    DOI 10.12688/f1000research.8812.1
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel ; Online: Beyond methotrexate monotherapy for early rheumatoid arthritis.

    Scott, David L

    Lancet (London, England)

    2016  Band 388, Heft 10042, Seite(n) 309–310

    Mesh-Begriff(e) Antibodies, Monoclonal, Humanized/therapeutic use ; Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Female ; Humans ; Male ; Methotrexate/therapeutic use
    Chemische Substanzen Antibodies, Monoclonal, Humanized ; Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
    Sprache Englisch
    Erscheinungsdatum 2016-07-23
    Erscheinungsland England
    Dokumenttyp Comment ; Journal Article
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(16)30678-X
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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