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  1. Buch ; Dissertation / Habilitation: Die extrazerebrale Toxoplasmose im Autopsiegut bei Verstorbenen mit AIDS

    Sell, Manfred

    1991  

    Verfasserangabe vorgelegt von Manfred Sell
    Umfang 1 Mikrofiche : 24x
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Berlin, Freie Univ., Diss., 1991
    Anmerkung Mikroreprod. eines Ms. 92 Bl.: Ill., graph. Darst.
    HBZ-ID HT004316281
    Datenquelle Katalog ZB MED Medizin, Gesundheit

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  2. Artikel ; Online: Obesity induced by Borna disease virus in rats: key roles of hypothalamic fast-acting neurotransmitters and inflammatory infiltrates.

    Gosztonyi, Georg / Ludwig, Hanns / Bode, Liv / Kao, Moujahed / Sell, Manfred / Petrusz, Peter / Halász, Béla

    Brain structure & function

    2020  Band 225, Heft 5, Seite(n) 1459–1482

    Abstract: Human obesity epidemic is increasing worldwide with major adverse consequences on health. Among other possible causes, the hypothesis of an infectious contribution is worth it to be considered. Here, we report on an animal model of virus-induced obesity ... ...

    Abstract Human obesity epidemic is increasing worldwide with major adverse consequences on health. Among other possible causes, the hypothesis of an infectious contribution is worth it to be considered. Here, we report on an animal model of virus-induced obesity which might help to better understand underlying processes in human obesity. Eighty Wistar rats, between 30 and 60 days of age, were intracerebrally inoculated with Borna disease virus (BDV-1), a neurotropic negative-strand RNA virus infecting an unusually broad host spectrum including humans. Half of the rats developed fatal encephalitis, while the other half, after 3-4 months, continuously gained weight. At tripled weights, rats were sacrificed by trans-cardial fixative perfusion. Neuropathology revealed prevailing inflammatory infiltrates in the median eminence (ME), progressive degeneration of neurons of the paraventricular nucleus, the entorhinal cortex and the amygdala, and a strikingly high-grade involution of the hippocampus with hydrocephalus. Immune histology revealed that major BDV-1 antigens were preferentially present at glutamatergic receptor sites, while GABAergic areas remained free from BDV-1. Virus-induced suppression of the glutamatergic system caused GABAergic predominance. In the hypothalamus, this shifted the energy balance to the anabolic appetite-stimulating side governed by GABA, allowing for excessive fat accumulation in obese rats. Furthermore, inflammatory infiltrates in the ME and ventro-medial arcuate nucleus hindered free access of appetite-suppressing hormones leptin and insulin. The hormone transport system in hypothalamic areas outside the ME became blocked by excessively produced leptin, leading to leptin resistance. The resulting hyperleptinemic milieu combined with suppressed glutamatergic mechanisms was a characteristic feature of the found metabolic pathology. In conclusion, the study provided clear evidence that BDV-1 induced obesity in the rat model is the result of interdependent structural and functional metabolic changes. They can be explained by an immunologically induced hypothalamic microcirculation-defect, combined with a disturbance of neurotransmitter regulatory systems. The proposed mechanism may also have implications for human health. BDV-1 infection has been frequently found in depressive patients. Independently, comorbidity between depression and obesity has been reported, either. Future studies should address the exciting question of whether BDV-1 infection could be a link, whatsoever, between these two conditions.
    Mesh-Begriff(e) Animals ; Borna Disease/complications ; Borna Disease/metabolism ; Borna Disease/pathology ; Borna disease virus/physiology ; Brain/metabolism ; Brain/pathology ; Brain/virology ; Encephalitis, Viral/pathology ; Hypothalamus/metabolism ; Hypothalamus/pathology ; Hypothalamus/virology ; Neurons/metabolism ; Neurons/pathology ; Neurons/virology ; Neuropeptides/metabolism ; Obesity/metabolism ; Obesity/pathology ; Obesity/virology ; Rats, Wistar
    Chemische Substanzen Neuropeptides
    Sprache Englisch
    Erscheinungsdatum 2020-05-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 2273162-3
    ISSN 1863-2661 ; 1863-2653
    ISSN (online) 1863-2661
    ISSN 1863-2653
    DOI 10.1007/s00429-020-02063-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Buch ; Dissertation / Habilitation: Die extrazerebrale Toxoplasmose im Autopsiegut bei Verstorbenen mit AIDS

    Sell, Manfred

    1991  

    Verfasserangabe vorgelegt von Manfred Sell
    Sprache Nicht zu entscheiden
    Umfang 1 Mikrofiche, 24x
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation @Berlin, Freie Univ., Diss. : 1991 (Nur als Mikrofiche für den Austausch)
    Anmerkung Mikroreprod. eines Ms. 92 Bl. : Ill., graph. Darst.
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

    Zusatzmaterialien

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  4. Artikel: Ventriculitis and hydrocephalus as the primary manifestation of cerebral toxoplasmosis associated with AIDS.

    Sell, Manfred / Sander, Bernhard / Klingebiel, Randolf

    Journal of neurology

    2005  Band 252, Heft 2, Seite(n) 234–236

    Mesh-Begriff(e) Acquired Immunodeficiency Syndrome/complications ; Acquired Immunodeficiency Syndrome/pathology ; Acquired Immunodeficiency Syndrome/virology ; Homosexuality ; Humans ; Hydrocephalus/etiology ; Immunohistochemistry/methods ; Magnetic Resonance Imaging/methods ; Male ; Middle Aged ; Staining and Labeling/methods ; Toxoplasmosis, Cerebral/complications ; Toxoplasmosis, Cerebral/pathology ; Toxoplasmosis, Cerebral/virology ; Vasculitis, Central Nervous System/etiology
    Sprache Englisch
    Erscheinungsdatum 2005-02
    Erscheinungsland Germany
    Dokumenttyp Letter
    ZDB-ID 187050-6
    ISSN 1432-1459 ; 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    ISSN (online) 1432-1459
    ISSN 0340-5354 ; 0012-1037 ; 0939-1517 ; 1619-800X
    DOI 10.1007/s00415-005-0620-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Buch ; Dissertation / Habilitation: Musikantenleben

    Sell, Manfred

    zur Volkskunde und Sozialgeschichte ländlich lebender Musikanten im ausgehenden 19. Jahrhundert

    (Schriften des Freilichtmuseums am Kiekeberg ; 2)

    1988  

    Körperschaft Freilichtmuseum am Kiekeberg
    Verfasserangabe Manfred Sell
    Serientitel Schriften des Freilichtmuseums am Kiekeberg ; 2
    Sprache Deutsch
    Umfang 80 S, Ill., graph. Darst
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Zugl.: Hamburg, Univ., Magisterarbeit, 1988 u.d.T.: Sell: Heidjers Tanzmusik
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  6. Buch ; Dissertation / Habilitation: Heidjers Tanzmusik

    Sell, Manfred

    zur Volkskunde und Sozialgeschichte ländlich lebender Musikanten im ausgehenden 19. Jahrhundert

    1987  

    Verfasserangabe vorgelegt von Manfred Sell
    Sprache Deutsch
    Umfang 109 S, Ill
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Univ., Mag.-Schr. (Nicht f. d. Austausch)--Hamburg, 1988
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  7. Artikel: Congenital glioblastoma multiforme with abnormal vascularity presenting as intracranial hemorrhage in prenatal ultrasound.

    Sell, Manfred / Huber-Schumacher, Sabine / van Landeghem, Frank K H

    Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

    2006  Band 22, Heft 7, Seite(n) 729–733

    Abstract: Background: A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory ... ...

    Abstract Background: A rare case of a congenital brain neoplasm with intratumoral massive hemorrhage suggested by prenatal ultrasound examination in a 32-week gestational age male fetus is reported. The child died shortly after birth due to cardiorespiratory insufficiency.
    Methods: Autopsy disclosed a large well-delimited tumor with a sponge-like appearance due to high vascularization, which involved nearly the whole left cerebral hemisphere and led to marked hydrocephalus by secondary aqueductal stenosis. Histological and immunohistochemical examination confirmed the diagnosis of a malignant glioma with features of a glioblastoma multiforme (GBM) matching well with previous findings in primary pediatric GBMs.
    Findings: The present case demonstrates that malignant congenital neoplasms should be considered in the differential diagnosis of fetal intracranial hemorrhage.
    Mesh-Begriff(e) Adult ; Brain Neoplasms/complications ; Brain Neoplasms/diagnostic imaging ; Brain Neoplasms/pathology ; Female ; Fetal Diseases/diagnostic imaging ; Fetal Diseases/pathology ; Fetus ; Glioblastoma/complications ; Glioblastoma/diagnostic imaging ; Glioblastoma/pathology ; Humans ; Intracranial Hemorrhages/diagnostic imaging ; Intracranial Hemorrhages/etiology ; Intracranial Hemorrhages/pathology ; Male ; Pregnancy ; Ultrasonography, Prenatal/methods
    Sprache Englisch
    Erscheinungsdatum 2006-05-04
    Erscheinungsland Germany
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 605988-0
    ISSN 1433-0350 ; 0256-7040 ; 0302-2803
    ISSN (online) 1433-0350
    ISSN 0256-7040 ; 0302-2803
    DOI 10.1007/s00381-006-0049-z
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  8. Buch ; Konferenzbeitrag: Waschen - eine saubere Sache

    Sell, Manfred / Fahl, Andreas

    (Schriften des Freilichtmuseums am Kiekeberg ; 7)

    1991  

    Körperschaft Freilichtmuseum am Kiekeberg
    Veranstaltung/Kongress Sonderausstellung Waschen - eine saubere Sache (1, 1991, Ehestorf)
    Verfasserangabe Manfred Sell. Mit Beitr. von Andreas Fahl
    Serientitel Schriften des Freilichtmuseums am Kiekeberg ; 7
    Sprache Deutsch
    Umfang 80 S, Ill., graph. Darst
    Verlag Selbstverl
    Erscheinungsort Ehestorf
    Dokumenttyp Buch ; Konferenzbeitrag
    ISBN 3927521094 ; 9783927521094
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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  9. Buch ; Konferenzbeitrag: Waschen - eine saubere Sache

    Sell, Manfred / Fahl, Andreas

    (Schriften des Freilichtmuseums am Kiekeberg ; 7)

    1991  

    Körperschaft Freilichtmuseum am Kiekeberg
    Veranstaltung/Kongress Sonderausstellung Waschen - eine saubere Sache (1, 1991, Ehestorf)
    Verfasserangabe Manfred Sell. Mit Beitr. von Andreas Fahl
    Serientitel Schriften des Freilichtmuseums am Kiekeberg ; 7
    Sprache Deutsch
    Umfang 80 S, Ill., graph. Darst
    Verlag Selbstverl
    Erscheinungsort Ehestorf
    Dokumenttyp Buch ; Konferenzbeitrag
    ISBN 3927521094 ; 9783927521094
    Datenquelle Katalog der Technische Informationsbibliothek Hannover

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  10. Buch: Die neutralen Alpen

    Sell, Manfred

    1965  

    Verfasserangabe Manfred Sell
    Sprache Deutsch
    Umfang 241 S, Kt
    Verlag Seewald
    Erscheinungsort Stuttgart
    Dokumenttyp Buch
    Datenquelle Ehemaliges Sondersammelgebiet Küsten- und Hochseefischerei

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