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  1. Artikel ; Online: Navigating the tumor microenvironment: mesenchymal stem cell-mediated delivery of anticancer agents.

    Waqar, Muhammad Ahsan / Zaman, Muhammad / Khan, Rabeel / Shafeeq Ur Rahman, Muhammad / Majeed, Imtiaz

    Journal of drug targeting

    2024  , Seite(n) 1–11

    Abstract: Scientific knowledge of cancer has advanced greatly throughout the years, with most recent studies findings includes many hallmarks that capture disease's multifaceted character. One of the novel approach utilised for the delivery of anti-cancer agents ... ...

    Abstract Scientific knowledge of cancer has advanced greatly throughout the years, with most recent studies findings includes many hallmarks that capture disease's multifaceted character. One of the novel approach utilised for the delivery of anti-cancer agents includes mesenchymal stem cell mediated drug delivery. Mesenchymal stem cells (MSCs) are non-haematopoietic progenitor cells that may be extracted from bone marrow, tooth pulp, adipose tissue and placenta/umbilical cord blood dealing with adult stem cells. MSCs are mostly involved in regeneration of tissue, they have also been shown to preferentially migrate to location of several types of tumour
    Sprache Englisch
    Erscheinungsdatum 2024-05-06
    Erscheinungsland England
    Dokumenttyp Journal Article ; Review
    ZDB-ID 1187110-6
    ISSN 1029-2330 ; 1061-186X
    ISSN (online) 1029-2330
    ISSN 1061-186X
    DOI 10.1080/1061186X.2024.2347356
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  2. Artikel ; Online: Greenhouse gas emissions, carbon stocks and wheat productivity following biochar, compost and vermicompost amendments: comparison of non-saline and salt-affected soils.

    Farooqi, Zia Ur Rahman / Qadir, Ayesha Abdul / Khalid, Sehrish / Murtaza, Ghulam / Ashraf, Muhammad Nadeem / Shafeeq-Ur-Rahman / Javed, Wasim / Waqas, Muhammad Ahmed / Xu, Minggang

    Scientific reports

    2024  Band 14, Heft 1, Seite(n) 7752

    Abstract: Understanding the impact of greenhouse gas (GHG) emissions and carbon stock is crucial for effective climate change assessment and agroecosystem management. However, little is known about the effects of organic amendments on GHG emissions and dynamic ... ...

    Abstract Understanding the impact of greenhouse gas (GHG) emissions and carbon stock is crucial for effective climate change assessment and agroecosystem management. However, little is known about the effects of organic amendments on GHG emissions and dynamic changes in carbon stocks in salt-affected soils. We conducted a pot experiment with four treatments including control (only fertilizers addition), biochar, vermicompost, and compost on non-saline and salt-affected soils, with the application on a carbon equivalent basis under wheat crop production. Our results revealed that the addition of vermicompost significantly increased soil organic carbon content by 18% in non-saline soil and 52% in salt-affected soil compared to the control leading to improvements in crop productivity i.e., plant dry biomass production by 57% in non-saline soil with vermicompost, while 56% with the same treatment in salt-affected soil. The grain yield was also noted 44 and 50% more with vermicompost treatment in non-saline and salt-affected soil, respectively. Chlorophyll contents were observed maximum with vermicompost in non-saline (24%), and salt-affected soils (22%) with same treatments. Photosynthetic rate (47% and 53%), stomatal conductance (60% and 12%), and relative water contents (38% and 27%) were also noted maximum with the same treatment in non-saline and salt-affected soils, respectively. However, the highest carbon dioxide emissions were observed in vermicompost- and compost-treated soils, leading to an increase in emissions of 46% in non-saline soil and 74% in salt-affected soil compared to the control. The compost treatment resulted in the highest nitrous oxide emissions, with an increase of 57% in non-saline soil and 62% in salt-affected soil compared to the control. In saline and non-saline soils treated with vermicompost, the global warming potential was recorded as 267% and 81% more than the control, respectively. All treatments, except biochar in non-saline soil, showed increased net GHG emissions due to organic amendment application. However, biochar reduced net emissions by 12% in non-saline soil. The application of organic amendments increased soil organic carbon content and crop yield in both non-saline and salt-affected soils. In conclusion, biochar is most effective among all tested organic amendments at increasing soil organic carbon content in both non-saline and salt-affected soils, which could have potential benefits for soil health and crop production.
    Mesh-Begriff(e) Soil ; Greenhouse Gases ; Agriculture/methods ; Triticum ; Carbon ; Composting ; Charcoal ; Sodium Chloride ; Sodium Chloride, Dietary ; Nitrous Oxide/analysis ; Carbon Dioxide/analysis
    Chemische Substanzen Soil ; Greenhouse Gases ; biochar ; Carbon (7440-44-0) ; Charcoal (16291-96-6) ; Sodium Chloride (451W47IQ8X) ; Sodium Chloride, Dietary ; Nitrous Oxide (K50XQU1029) ; Carbon Dioxide (142M471B3J)
    Sprache Englisch
    Erscheinungsdatum 2024-04-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-56381-y
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  3. Artikel ; Online: Assessing the Effect of Irrigation Using Different Water Resources on Characteristics of Mild Cadmium-Contaminated Soil and Tomato Quality

    Jiaxin Cui / Ping Li / Xuebin Qi / Wei Guo / Shafeeq Ur Rahman

    Agronomy, Vol 12, Iss 2721, p

    2022  Band 2721

    Abstract: As the world economy and society have developed quickly, the amount of farmland soil pollution has become alarming, which has seriously threatened global food security. It is necessary to take effective measures on the moderately contaminated soil to ... ...

    Abstract As the world economy and society have developed quickly, the amount of farmland soil pollution has become alarming, which has seriously threatened global food security. It is necessary to take effective measures on the moderately contaminated soil to produce high-quality food and to protect food security worldwide by effective use of land resources. Our experimental design was to study the changes in soil physicochemical properties and tomato yield and quality indicators by irrigating tomatoes on cadmium-contaminated soil with two different water qualities (reclaimed water irrigation: RW; tap water irrigation: TW) through drip irrigation devices. Tomato quality indicators were determined using plant physiological assays, as well as vitamin C (VC), total acidity (TA), protein content (PC), and soluble sugar content (SS). We tested five different types of cadmium-contaminated soils (less than 0.60 mg/kg, 0.60–1.20 mg/kg, 1.20–1.80 mg/kg, 1.80–2.40 mg/kg, 2.40–3.00 mg/kg) against RW and TW, and performed high-throughput sequencing of the soils to obtain environmental results for soil microbial diversity. The results reveal that compared with the TW condition, soil nutritional status was increased with the irrigated RW. The yield of the tomatoes increased by 52.03–94.03% than TW. The results of the study showed significant and highly significant relationships between tomato quality indicators (TA, SS, yield) and soil physical and chemical properties indicators ( p < 0.01, 0.05). For instance, the RW increased the SOM by 6.54–12.13%, the TP by 0.48–24.73%, the yield of the tomatoes by 52.03–94.03% than TW, while the cadmium content did not show significant differences ( p < 0.05), and the cadmium content did not increase the soil’s pollution level. Compared with TW treatment, RW treatment alleviated the inhibition of soil microbial diversity by cadmium and RW also increased its soil microbial diversity. The relative abundance of Proteobacteria , Gemmatimonadetes , and Bacteroidetes in the RW condition were ...
    Schlagwörter cadmium contaminates soil ; reclaimed water ; tap water ; soil characteristics ; tomatoes quality parameters ; soil microbial diversity ; Agriculture ; S
    Thema/Rubrik (Code) 500 ; 630
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
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  4. Artikel: Correction: Zaman et al. Synthesis and Evaluation of Thiol-Conjugated Poloxamer and Its Pharmaceutical Applications.

    Zaman, Muhammad / Saeed, Sadaf / Imtiaz Bajwa, Rabia / Shafeeq Ur Rahman, Muhammad / Rahman, Saeed Ur / Jamshaid, Muhammad / Rasool, Muhammad F / Majeed, Abdul / Imran, Imran / Alqahtani, Faleh / Alshehri, Sultan / AlAsmari, Abdullah F / Ali, Nemat / Alasmari, Mohammed S

    Pharmaceutics

    2024  Band 16, Heft 5

    Abstract: In the original publication, there was a mistake in one author name, Mohammed Alasmari should be Mohammed S [ ... ]. ...

    Abstract In the original publication, there was a mistake in one author name, Mohammed Alasmari should be Mohammed S [...].
    Sprache Englisch
    Erscheinungsdatum 2024-05-20
    Erscheinungsland Switzerland
    Dokumenttyp Published Erratum
    ZDB-ID 2527217-2
    ISSN 1999-4923
    ISSN 1999-4923
    DOI 10.3390/pharmaceutics16050690
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  5. Artikel ; Online: Cadmium stress in paddy fields: Effects of soil conditions and remediation strategies.

    Hussain, Babar / Ashraf, Muhammad Nadeem / Shafeeq-Ur-Rahman / Abbas, Aqleem / Li, Jumei / Farooq, Muhammad

    The Science of the total environment

    2020  Band 754, Seite(n) 142188

    Abstract: Cadmium (Cd) toxicity in paddy soil and accumulation in rice plants and grains have got global concern due to its health effects. This review highlights the effects of soil factors including soil organic matter, soil pH, redox potential, and soil ... ...

    Abstract Cadmium (Cd) toxicity in paddy soil and accumulation in rice plants and grains have got global concern due to its health effects. This review highlights the effects of soil factors including soil organic matter, soil pH, redox potential, and soil microbes which influencing Cd uptake by rice plant. Therefore, a comprehensive review of innovative and environmentally friendly management practices for managing Cd stress in rice is lacking. Thus, this review discusses the effect of Cd toxicity in rice and describes management strategies to offset its effects. Moreover, future research thrusts to reduce its uptake by rice has also been highlighted. Through phytoremediation, Cd may be extracted and stabilized in the soil while through microbes Cd can be sequestrated inside the microbial bodies. Increased Cd uptake in hyperaccumulator plants to remediate and convert the toxic form of Cd into non-toxic forms. While in chemical remediation, Cd can be washed out, immobilized and stabilized in the soil through chemical amendments. The organic amendments may help through an increase in soil pH, adsorption in its functional groups, the formation of complexations, and the conversion of exchangeable to residual forms. Developing rice genotypes with restricted Cd uptake and reduced accumulation in grain through conventional and marker-assisted breeding are fundamental keys for safe rice production. In this regard, the use of molecular techniques including identification of QTLs, CRISPR/Cas9, and functional genomics may be quite helpful.
    Mesh-Begriff(e) Cadmium/analysis ; Cadmium/toxicity ; Edible Grain/chemistry ; Oryza ; Soil ; Soil Pollutants/analysis ; Soil Pollutants/toxicity
    Chemische Substanzen Soil ; Soil Pollutants ; Cadmium (00BH33GNGH)
    Sprache Englisch
    Erscheinungsdatum 2020-09-07
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2020.142188
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  6. Artikel: Statistically Optimized Polymeric Buccal Films of Eletriptan Hydrobromide and Itopride Hydrochloride: An In Vivo Pharmacokinetic Study.

    Safhi, Awaji Y / Siddique, Waqar / Zaman, Muhammad / Sarfraz, Rai Muhammad / Shafeeq Ur Rahman, Muhammad / Mahmood, Asif / Salawi, Ahmad / Sabei, Fahad Y / Alsalhi, Abdullah / Zoghebi, Khalid

    Pharmaceuticals (Basel, Switzerland)

    2023  Band 16, Heft 11

    Abstract: A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric buccal films of Eletriptan Hydrobromide (EHBR) and Itopride Hydrochloride ( ... ...

    Abstract A migraine is a condition of severe headaches, causing a disturbance in the daily life of the patient. The current studies were designed to develop immediate-release polymeric buccal films of Eletriptan Hydrobromide (EHBR) and Itopride Hydrochloride (ITHC) to improve their bioavailability and, hence, improve compliance with the patients of migraines and its associated symptoms. The prepared films were evaluated for various in vitro parameters, including surface morphology, mechanical strength, disintegration test (DT), total dissolving time (TDT), drug release and drug permeation, etc., and in vivo pharmacokinetic parameters, such as area under curve (AUC), mean residence time (MRT), half-life (t
    Sprache Englisch
    Erscheinungsdatum 2023-11-02
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16111551
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  7. Artikel ; Online: Aluminum phytotoxicity in acidic environments

    Shafeeq Ur Rahman / Jing-Cheng Han / Muhammad Ahmad / Muhammad Nadeem Ashraf / Muhammad Athar Khaliq / Maryam Yousaf / Yuchen Wang / Ghulam Yasin / Muhammad Farrakh Nawaz / Khalid Ali Khan / Zhenjie Du

    Ecotoxicology and Environmental Safety, Vol 269, Iss , Pp 115791- (2024)

    A comprehensive review of plant tolerance and adaptation strategies

    1481  

    Abstract: Aluminum (Al), a non-essential metal for plant growth, exerts significant phytotoxic effects, particularly on root growth. Anthropogenic activities would intensify Al’s toxic effects by releasing Al3+ into the soil solution, especially in acidic soils ... ...

    Abstract Aluminum (Al), a non-essential metal for plant growth, exerts significant phytotoxic effects, particularly on root growth. Anthropogenic activities would intensify Al’s toxic effects by releasing Al3+ into the soil solution, especially in acidic soils with a pH lower than 5.5 and rich mineral content. The severity of Al-induced phytotoxicity varies based on factors such as Al concentration, ionic form, plant species, and growth stages. Al toxicity leads to inhibited root and shoot growth, reduced plant biomass, disrupted water uptake causing nutritional imbalance, and adverse alterations in physiological, biochemical, and molecular processes. These effects collectively lead to diminished plant yield and quality, along with reduced soil fertility. Plants employ various mechanisms to counter Al toxicity under stress conditions, including sequestering Al in vacuoles, exuding organic acids (OAs) like citrate, oxalate, and malate from root tip cells to form Al-complexes, activating antioxidative enzymes, and overexpressing Al-stress regulatory genes. Recent advancements focus on enhancing the exudation of OAs to prevent Al from entering the plant, and developing Al-tolerant varieties. Gene transporter families, such as ATP-Binding Cassette (ABC), Aluminum-activated Malate Transporter (ALMT), Natural resistance-associated macrophage protein (Nramp), Multidrug and Toxic compounds Extrusion (MATE), and aquaporin, play a crucial role in regulating Al toxicity. This comprehensive review examined recent progress in understanding the cytotoxic impact of Al on plants at the cellular and molecular levels. Diverse strategies developed by both plants and scientists to mitigate Al-induced phytotoxicity were discussed. Furthermore, the review explored recent genomic developments, identifying candidate genes responsible for OAs exudation, and delved into genome-mediated breeding initiatives, isolating transgenic and advanced breeding lines to cultivate Al-tolerant plants.
    Schlagwörter Aluminum toxicity ; Acidic soils ; Aluminum transporters ; Plant physiological responses ; Genomics ; Organic acids ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2024-01-01T00:00:00Z
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
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  8. Artikel ; Online: Biotreatment potential of co-contaminants hexavalent chromium and polychlorinated biphenyls in industrial wastewater: Individual and simultaneous prospects.

    Yasir, Muhammad Wahab / Siddique, Muhammad Bashir Ahmed / Shabbir, Zunera / Ullah, Habib / Riaz, Luqman / Nisa, Waqar-Un- / Shafeeq-Ur-Rahman / Shah, Anis Ali

    The Science of the total environment

    2021  Band 779, Seite(n) 146345

    Abstract: Co-existence of polychlorinated biphenyls (PCBs) and hexavalent chromium (Cr(VI)) in the environment due to effluent from industries has aggravated the pollution problem. Both contaminants can alter chemical interactions, processes and impair enzymatic ... ...

    Abstract Co-existence of polychlorinated biphenyls (PCBs) and hexavalent chromium (Cr(VI)) in the environment due to effluent from industries has aggravated the pollution problem. Both contaminants can alter chemical interactions, processes and impair enzymatic activities in the ecosystem that results in negative impacts on aquatic and terrestrial life. Previously, research has been performed for the fate and transfer of these contaminants individually, but simultaneous removal approaches have not received much attention. Cr(VI) exists in a highly toxic form in the environment once released, whereas location of chlorine atoms in the ring determines PCBs toxicity. Lower chlorinated compounds are easily degradable whereas as high chlorinated compounds require sequential strategy for transformation. Microorganisms can develop different mechanism to detoxify both pollutants. However, occurrence of multiple contaminants in single system can alter the bioremediation efficiency of bacteria. Use of metal resistance bacterial for the degradation of organic compounds has been widely used bioaugmentation strategy. Along with that use of sorbents/bio sorbents, biosurfactants and phytoremediation approaches have already been well reported. Bioremediation strategy with dual potential to detoxify the Cr(VI) and PCBs would be a probable option for simultaneous biotreatment. Application of bioreactors and biofilms covered organic particles can be utilized as efficient bioaugmentation approach. In this review, biotreatment systems and bacterial oxidative and reductive enzymes/processes are explained and possible biotransformation pathway has been purposed for bioremediation of co-contaminated waters.
    Mesh-Begriff(e) Biodegradation, Environmental ; Chromium/analysis ; Ecosystem ; Polychlorinated Biphenyls ; Waste Water
    Chemische Substanzen Waste Water ; Chromium (0R0008Q3JB) ; chromium hexavalent ion (18540-29-9) ; Polychlorinated Biphenyls (DFC2HB4I0K)
    Sprache Englisch
    Erscheinungsdatum 2021-03-12
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Review
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2021.146345
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  9. Artikel ; Online: State-of-the-art OMICS strategies against toxic effects of heavy metals in plants

    Shafeeq Ur Rahman / Muhammad Farrakh Nawaz / Sadaf Gul / Ghulam Yasin / Babar Hussain / Yanliang Li / Hefa Cheng

    Ecotoxicology and Environmental Safety, Vol 242, Iss , Pp 113952- (2022)

    A review

    2022  

    Abstract: Environmental pollution of heavy metals (HMs), mainly due to anthropogenic activities, has received growing attention in recent decades. HMs, especially the non-essential carcinogenic ones, including chromium (Cr), cadmium (Cd), mercury (Hg), aluminum ( ... ...

    Abstract Environmental pollution of heavy metals (HMs), mainly due to anthropogenic activities, has received growing attention in recent decades. HMs, especially the non-essential carcinogenic ones, including chromium (Cr), cadmium (Cd), mercury (Hg), aluminum (Al), lead (Pb), and arsenic (As), have appeared as the most significant air, water, and soil pollutants, which adversely affect the quantity, quality, and security of plant-based food all over the world. Plants exposed to HMs could experience significant decline in growth and yield. To avoid or tolerate the toxic effects of HMs, plants have developed complicated defense mechanisms, including absorption and accumulation of HMs in cell organelles, immobilization by forming complexes with organic chelates, extraction by using numerous transporters, ion channels, signalling cascades, and transcription elements, among others. OMICS strategies have developed significantly to understand the mechanisms of plant transcriptomics, genomics, proteomics, metabolomics, and ionomics to counter HM-mediated stress stimuli. These strategies have been considered to be reliable and feasible for investigating the roles of genomics (genomes), transcriptomic (coding), mRNA transcripts (non-coding), metabolomics (metabolites), and ionomics (metal ions) to enhance stress resistance or tolerance in plants. The recent developments in the mechanistic understandings of the HMs-plant interaction in terms of their absorption, translocation, and toxicity invasions at the molecular and cellular levels, as well as plants' response and adaptation strategies against these stressors, are summarized in the present review. Transcriptomics, genomics, metabolomics, proteomics, and ionomics for plants against HMs toxicities are reviewed, while challenges and future recommendations are also discussed.
    Schlagwörter Abiotic stress ; Genomics ; Ionomics ; Metabolomics ; Proteomics ; Transcriptomics ; Environmental pollution ; TD172-193.5 ; Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 580
    Sprache Englisch
    Erscheinungsdatum 2022-09-01T00:00:00Z
    Verlag Elsevier
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  10. Artikel ; Online: Soil microbial and enzyme activities in different land use systems of the Northwestern Himalayas

    Yasir Hanif Mir / Mumtaz Ahmad Ganie / Tajamul Islam Shah / Shabir Ahmed Bangroo / Shakeel Ahmad Mir / Aanisa Manzoor Shah / Fehim Jeelani Wani / Anzhen Qin / Shafeeq Ur Rahman

    PeerJ, Vol 11, p e

    2023  Band 15993

    Abstract: Soil microbial activity (SMA) is vital concerning carbon cycling, and its functioning is recognized as the primary factor in modifying soil carbon storage potential. The composition of the microbial community (MC) is significant in sustaining ... ...

    Abstract Soil microbial activity (SMA) is vital concerning carbon cycling, and its functioning is recognized as the primary factor in modifying soil carbon storage potential. The composition of the microbial community (MC) is significant in sustaining environmental services because the structure and activity of MC also influence nutrient turnover, distribution, and the breakdown rate of soil organic matter. SMA is an essential predictor of soil quality alterations, and microbiome responsiveness is imperative in addressing the escalating sustainability concerns in the Himalayan ecosystem. This study was conducted to evaluate the response of soil microbial and enzyme activities to land conversions in the Northwestern Himalayas (NWH), India. Soil samples were collected from five land use systems (LUSs), including forest, pasture, apple, saffron, and paddy-oilseed, up to a depth of 90 cm. The results revealed a significant difference (p < 0.05) in terms of dehydrogenase (9.97–11.83 TPF µg g−1 day−1), acid phosphatase (22.40–48.43 µg P-NP g−1 h−1), alkaline phosphatase (43.50–61.35 µg P-NP g−1 h−1), arylsulphatase (36.33–48.12 µg P-NP g−1 h−1), fluorescein diacetate hydrolase (12.18–21.59 µg g−1 h−1), bacterial count (67.67–123.33 CFU × 106 g−1), fungal count (19.33–67.00 CFU × 105 g−1), and actinomycetes count (12.00–42.33 CFU × 104 g−1), with the highest and lowest levels in forest soils and paddy-oilseed soils, respectively. Soil enzyme activities and microbial counts followed a pattern: forest > pasture > apple > saffron > paddy-oilseed at all three depths. Paddy-oilseed soils exhibited up to 35% lower enzyme activities than forest soils, implying that land conversion facilitates the depletion of microbiome diversity from surface soils. Additionally, reductions of 49.80% and 62.91% were observed in enzyme activity and microbial counts, respectively, with soil depth (from 0–30 to 60–90 cm). Moreover, the relationship analysis (principal component analysis and correlation) revealed a high and significant (p = ...
    Schlagwörter Arylsulphatase activity ; Dehydrogenase activity ; Ecosystem ; Land use ; Microbial population ; Soil sustainability ; Medicine ; R ; Biology (General) ; QH301-705.5
    Sprache Englisch
    Erscheinungsdatum 2023-09-01T00:00:00Z
    Verlag PeerJ Inc.
    Dokumenttyp Artikel ; Online
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