Article ; Online: Predictive urinary RNA biomarkers of kidney injury after extracorporeal shock wave lithotripsy.
2022 Volume 40, Issue 6, Page(s) 1561–1567
Abstract: Background: Extracorporeal shock wave lithotripsy (ESWL) is considered one of the best choices for the treatment of various kinds of urinary tract calculi, although it might cause acute kidney injury.: Objective: To measure the urinary long non- ... ...
| Abstract | Background: Extracorporeal shock wave lithotripsy (ESWL) is considered one of the best choices for the treatment of various kinds of urinary tract calculi, although it might cause acute kidney injury. Objective: To measure the urinary long non-coding RNA-messenger RNA (LncRNA-mRNA) panel before and after ESWL to evaluate post-ESWL renal injury in a reliable and non-invasive method. Patients and methods: The study included 60 patients with renal stones treated with ESWL and 30 healthy volunteers. Voided urine samples were obtained before, 2 h, and 1 day after ESWL. We measured the urinary level of LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) by real-time qPCR and compared the results with serum creatinine and eGFR. Results: LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were higher in patients with renal stones when compared with healthy volunteers. They showed a statistically significant increase in the level of LncRNA-mRNA panel in baseline and after ESWL treatment. Conclusion: LncRNA (SBF2-AS1, FENDRR-19) and mRNA (GBP1, NLRP3) levels were significantly elevated following ESWL treatment, highlighting the usefulness of urinary biomarkers in identifying patients at higher risk of developing renal injury after ESWL treatment. |
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| MeSH term(s) | Acute Kidney Injury/etiology ; Acute Kidney Injury/urine ; Biomarkers/urine ; Humans ; Kidney/injuries ; Kidney/surgery ; Kidney Calculi/etiology ; Kidney Calculi/therapy ; Kidney Calculi/urine ; Lithotripsy/adverse effects ; NLR Family, Pyrin Domain-Containing 3 Protein/urine ; RNA, Long Noncoding/urine ; RNA, Messenger/urine | |||||
| Chemical Substances | Biomarkers ; NLR Family, Pyrin Domain-Containing 3 Protein ; RNA, Long Noncoding ; RNA, Messenger | |||||
| Language | English | |||||
| Publishing date | 2022-04-15 | |||||
| Publishing country | Germany | |||||
| Document type | Journal Article | |||||
| ZDB-ID | 380333-8 | |||||
| ISSN | 1433-8726 ; 0724-4983 | |||||
| ISSN (online) | 1433-8726 | |||||
| ISSN | 0724-4983 | |||||
| DOI | 10.1007/s00345-022-03996-3 | |||||
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| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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