LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 2 von insgesamt 2

Suchoptionen

  1. Artikel ; Online: In vivo

    Potts, Jonathan R / Farahi, Neda / Howard, Mark R / Taylor, Mark R / Heard, Sarah / Shankar, Arun N / Alexander, Graeme J / Chilvers, Edwin R / Verma, Sumita / Peters, A Michael

    Bioscience reports

    2018  Band 38, Heft 4

    Abstract: The study's aim was to image severe alcoholic hepatitis (SAH) ... ...

    Abstract The study's aim was to image severe alcoholic hepatitis (SAH) using
    Mesh-Begriff(e) Acute Disease ; Adult ; Cell Movement ; Female ; Hepatitis, Alcoholic/diagnostic imaging ; Hepatitis, Alcoholic/immunology ; Hepatitis, Alcoholic/pathology ; Humans ; Indium Radioisotopes/analysis ; Liver/diagnostic imaging ; Liver/immunology ; Liver/pathology ; Male ; Middle Aged ; Neutrophil Infiltration ; Neutrophils/immunology ; Neutrophils/pathology ; Radionuclide Imaging
    Chemische Substanzen Indium Radioisotopes
    Sprache Englisch
    Erscheinungsdatum 2018-07-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20180466
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1676: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel ; Online: Persistence of Hepatitis C Virus Traces after Spontaneous Resolution of Hepatitis C.

    Chen, Annie Y / Hoare, Matthew / Shankar, Arun N / Allison, Michael / Alexander, Graeme J M / Michalak, Tomasz I

    PloS one

    2015  Band 10, Heft 10, Seite(n) e0140312

    Abstract: Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited (spontaneous) resolution of hepatitis C was rarely investigated. The current study aimed to assess ...

    Abstract Hepatitis C virus (HCV) frequently causes chronic hepatitis, while spontaneous recovery from infection is infrequent. Persistence of HCV after self-limited (spontaneous) resolution of hepatitis C was rarely investigated. The current study aimed to assess incidence and robustness of HCV persistence after self-resolved hepatitis C in individuals with normal liver enzymes and undetectable virus by conventional tests. Applying high sensitivity HCV RNA detection approaches, we analyzed plasma and peripheral blood mononuclear cells (PBMC) from individuals with previous hepatitis C infection. Parallel plasma and PBMC from 24 such non-viraemic individuals followed for 0.3-14.4 (mean 6.4) years were examined. Additional samples from 9 of them were obtained 4.5-7.2 (mean 5.9) years later. RNA was extracted from 250 μl plasma and, if HCV negative, from ~5 ml after ultracentrifugation, and from ex vivo stimulated PBMC. PBMC with evidence of HCV replication from 4 individuals were treated with HCV protease inhibitor, telaprevir. HCV RNA was detected in 14/24 (58.3%) plasma and 11/23 (47.8%) PBMC obtained during the first collection. HCV RNA replicative strand was evident in 7/11 (63.6%) PBMC. Overall, 17/24 (70.8%) individuals carried HCV RNA at mean follow-up of 5.9 years. Samples collected 4.5-7.2 years later revealed HCV in 4/9 (44.4%) plasma and 5/9 (55.5%) PBMC, while 4 (80%) of these 5 PBMC demonstrated virus replicative strand. Overall, 6/9 (66.7%) individuals remained viraemic for up to 20.7 (mean 12.7) years. Telaprevir entirely eliminated HCV replication in the PBMC examined. In conclusion, our results indicate that HCV can persist long after spontaneous resolution of hepatitis C at levels undetectable by current testing. An apparently effective host immune response curtailing hepatitis appears insufficient to completely eliminate the virus. The long-term morbidity of asymptomatic HCV carriage should be examined even in individuals who achieve undetectable HCV by standard testing and their need for treatment should be assessed.
    Mesh-Begriff(e) Adult ; Aged ; Base Sequence ; Female ; Follow-Up Studies ; Hepacivirus/metabolism ; Hepatitis C, Chronic/blood ; Hepatitis C, Chronic/drug therapy ; Humans ; Leukocytes, Mononuclear/metabolism ; Leukocytes, Mononuclear/virology ; Male ; Middle Aged ; Molecular Sequence Data ; Oligopeptides/administration & dosage ; RNA, Viral/blood ; Remission, Spontaneous ; Time Factors
    Chemische Substanzen Oligopeptides ; RNA, Viral ; telaprevir (655M5O3W0U)
    Sprache Englisch
    Erscheinungsdatum 2015
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0140312
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang