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Artikel ; Online: The correlation between Flt3-ITD mutation in dendritic cells with TIM-3 expression in acute myeloid leukemia.

Shapoorian, Hooriyeh / Zalpoor, Hamidreza / Ganjalikhani-Hakemi, Mazdak

Blood science (Baltimore, Md.)

2021  Band 3, Heft 4, Seite(n) 132–135

Abstract: In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% ...

Abstract In general, acute myeloid leukemia (AML) is an aggressive and heterogeneous disease that is characterized by rapid cellular proliferation and high mortality. One of the mutations related to AML is the Flt3-ITD mutation, which is found in approximately 25% of patients. In this mini-review, we investigate the function of dendritic cells and T cells based on Flt3-ITD mutation and immune evasion as a result of this abnormality. Finally, we discuss some AML therapeutic strategies, including targeting Flt3 on DCs and TIM-3 on T cells as immune receptors to treat this hematopoietic malignancy.
Sprache Englisch
Erscheinungsdatum 2021-10-18
Erscheinungsland United States
Dokumenttyp Journal Article ; Review
ISSN 2543-6368
ISSN (online) 2543-6368
DOI 10.1097/BS9.0000000000000092
Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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