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  1. Dissertation / Habilitation ; Online: A Geographical Study of the SNAP Population in the United States

    Sheehan, Emily

    A County-Level Statistical Analysis

    2013  

    Abstract: Abstract not available. ...

    Abstract Abstract not available.
    Schlagwörter Geography|Statistics|Nutrition
    Sprache ENG
    Erscheinungsdatum 2013-01-01 00:00:01.0
    Verlag Southern Illinois University at Edwardsville
    Erscheinungsland us
    Dokumenttyp Dissertation / Habilitation ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel: Oral Mutian®X stopped faecal feline coronavirus shedding by naturally infected cats

    Addie, Diane D / Curran, Sheryl / Bellini, Flora / Crowe, Ben / Sheehan, Emily / Ukrainchuk, Lesya / Decaro, Nicola

    Research in veterinary science. 2020 June, v. 130

    2020  

    Abstract: Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® Xraphconn (Mutian X) is a product ...

    Abstract Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® Xraphconn (Mutian X) is a product marketed to treat cats with FIP but is also being used to stop virus shedding, although no clear guidelines exist for its use for this purpose. The aim of this study was to establish the minimum dose and treatment duration required to ensure viral clearance from the faeces of asymptomatic virus-shedding cats. In five multicat households, 29 cats naturally infected with FCoV and actively shedding virus in the faeces were given Mutian X pills. Virus shedding was monitored using reverse-transcription quantitative polymerase chain reaction (RT-qPCR) controlled for faecal inhibitors to ensure sensitivity. Mutian X given orally cleared the virus in 29 cats; although four cats required a repeated course to finally stop virus shedding. A dose of 4 mg/kg q24 h for four days was found to be the optimal treatment protocol: 2 mg/kg cleared only 80% of cats. Post-treatment using a sensitive RT-qPCR test was essential to ensure that virus clearance had been achieved, since failure to clear even one cat can result in re-infection of the others. Records of virus shedding by cats before treatment provided a retrospective control: significantly more cats stopped shedding virus after Mutian X than recovered from infection during the control period (p < .00001). This is the first report of the successful elimination of faecal FCoV shedding in chronically infected cats.
    Schlagwörter animal viruses ; cats ; feces ; feline infectious peritonitis ; guidelines ; households ; quantitative polymerase chain reaction ; reverse transcriptase polymerase chain reaction ; reverse transcription ; viral shedding ; virus transmission ; viruses ; covid19
    Sprache Englisch
    Erscheinungsverlauf 2020-06
    Umfang p. 222-229.
    Erscheinungsort Elsevier Ltd
    Dokumenttyp Artikel
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2020.02.012
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 2292: Hefte anzeigen

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  3. Artikel ; Online: Oral Mutian®X stopped faecal feline coronavirus shedding by naturally infected cats.

    Addie, Diane D / Curran, Sheryl / Bellini, Flora / Crowe, Ben / Sheehan, Emily / Ukrainchuk, Lesya / Decaro, Nicola

    Research in veterinary science

    2020  Band 130, Seite(n) 222–229

    Abstract: Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® Xraphconn (Mutian X) is a product ...

    Abstract Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® Xraphconn (Mutian X) is a product marketed to treat cats with FIP but is also being used to stop virus shedding, although no clear guidelines exist for its use for this purpose. The aim of this study was to establish the minimum dose and treatment duration required to ensure viral clearance from the faeces of asymptomatic virus-shedding cats. In five multicat households, 29 cats naturally infected with FCoV and actively shedding virus in the faeces were given Mutian X pills. Virus shedding was monitored using reverse-transcription quantitative polymerase chain reaction (RT-qPCR) controlled for faecal inhibitors to ensure sensitivity. Mutian X given orally cleared the virus in 29 cats; although four cats required a repeated course to finally stop virus shedding. A dose of 4 mg/kg q24 h for four days was found to be the optimal treatment protocol: 2 mg/kg cleared only 80% of cats. Post-treatment using a sensitive RT-qPCR test was essential to ensure that virus clearance had been achieved, since failure to clear even one cat can result in re-infection of the others. Records of virus shedding by cats before treatment provided a retrospective control: significantly more cats stopped shedding virus after Mutian X than recovered from infection during the control period (p < .00001). This is the first report of the successful elimination of faecal FCoV shedding in chronically infected cats.
    Mesh-Begriff(e) Administration, Oral ; Animals ; Antiviral Agents/therapeutic use ; Cats ; Coronavirus, Feline/drug effects ; Feces/virology ; Feline Infectious Peritonitis/drug therapy ; Retrospective Studies ; Virus Shedding/drug effects
    Chemische Substanzen Antiviral Agents
    Schlagwörter covid19
    Sprache Englisch
    Erscheinungsdatum 2020-02-19
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 840961-4
    ISSN 1532-2661 ; 0034-5288
    ISSN (online) 1532-2661
    ISSN 0034-5288
    DOI 10.1016/j.rvsc.2020.02.012
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 673: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Artikel ; Online: Oral Mutian®X stopped faecal feline coronavirus shedding by naturally infected cats

    Addie, Diane D. / Curran, Sheryl / Bellini, Flora / Crowe, Ben / Sheehan, Emily / Ukrainchuk, Lesya / Decaro, Nicola

    Research in Veterinary Science

    Abstract: Abstract Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® X is a product marketed ... ...

    Abstract Abstract Feline coronavirus (FCoV) is common among cats living indoors in groups. In about 10% of infected cats, a potentially lethal disease, feline infectious peritonitis (FIP) occurs. Virus transmission is faecal-oral. Mutian® X is a product marketed to treat cats with FIP but is also being used to stop virus shedding, although no clear guidelines exist for its use for this purpose. The aim of this study was to establish the minimum dose and treatment duration required to ensure viral clearance from the faeces of asymptomatic virus-shedding cats. In five multicat households, 29 cats naturally infected with FCoV and actively shedding virus in the faeces were given Mutian X pills. Virus shedding was monitored using reverse-transcription quantitative polymerase chain reaction (RT-qPCR) controlled for faecal inhibitors to ensure sensitivity. Mutian X given orally cleared the virus in 29 cats; although four cats required a repeated course to finally stop virus shedding. A dose of 4 mg/kg q24 h for four days was found to be the optimal treatment protocol: 2 mg/kg cleared only 80% of cats. Post-treatment using a sensitive RT-qPCR test was essential to ensure that virus clearance had been achieved, since failure to clear even one cat can result in re-infection of the others. Records of virus shedding by cats before treatment provided a retrospective control: significantly more cats stopped shedding virus after Mutian X than recovered from infection during the control period (p < .00001). This is the first report of the successful elimination of faecal FCoV shedding in chronically infected cats.
    Schlagwörter covid19
    Verlag Elsevier
    Dokumenttyp Artikel ; Online
    DOI 10.1016/j.rvsc.2020.02.012
    Datenquelle COVID19

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  5. Artikel: Time-Weighted Average SPME Analysis for in Planta Determination of cVOCs

    Sheehan, Emily M / Burken Joel G / Karlson Ulrich Gosewinkel / Limmer Matt A / Mayer Philipp

    Environmental Science & Technology. 2012 Mar. 20, v. 46, no. 6

    2012  

    Abstract: The potential of phytoscreening for plume delineation at contaminated sites has promoted interest in innovative, sensitive contaminant sampling techniques. Solid-phase microextraction (SPME) methods have been developed, offering quick, undemanding, ... ...

    Abstract The potential of phytoscreening for plume delineation at contaminated sites has promoted interest in innovative, sensitive contaminant sampling techniques. Solid-phase microextraction (SPME) methods have been developed, offering quick, undemanding, noninvasive sampling without the use of solvents. In this study, time-weighted average SPME (TWA-SPME) sampling was evaluated for in planta quantification of chlorinated solvents. TWA-SPME was found to have increased sensitivity over headspace and equilibrium SPME sampling. Using a variety of chlorinated solvents and a polydimethylsiloxane/carboxen (PDMS/CAR) SPME fiber, most compounds exhibited near linear or linear uptake over the sampling period. Smaller, less hydrophobic compounds exhibited more nonlinearity than larger, more hydrophobic molecules. Using a specifically designed in planta sampler, field sampling was conducted at a site contaminated with chlorinated solvents. Sampling with TWA-SPME produced instrument responses ranging from 5 to over 200 times higher than headspace tree core sampling. This work demonstrates that TWA-SPME can be used for in planta detection of a broad range of chlorinated solvents and methods can likely be applied to other volatile and semivolatile organic compounds.
    Schlagwörter headspace analysis ; hydrophobicity ; polydimethylsiloxane ; solid phase microextraction ; solvents ; time-weighted average ; trees ; volatile organic compounds
    Sprache Englisch
    Erscheinungsverlauf 2012-0320
    Umfang p. 3319-3325.
    Erscheinungsort American Chemical Society
    Dokumenttyp Artikel
    ISSN 1520-5851
    DOI 10.1021%2Fes2041898
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  6. Artikel ; Online: Time-weighted average SPME analysis for in planta determination of cVOCs.

    Sheehan, Emily M / Limmer, Matt A / Mayer, Philipp / Karlson, Ulrich Gosewinkel / Burken, Joel G

    Environmental science & technology

    2012  Band 46, Heft 6, Seite(n) 3319–3325

    Abstract: The potential of phytoscreening for plume delineation at contaminated sites has promoted interest in innovative, sensitive contaminant sampling techniques. Solid-phase microextraction (SPME) methods have been developed, offering quick, undemanding, ... ...

    Abstract The potential of phytoscreening for plume delineation at contaminated sites has promoted interest in innovative, sensitive contaminant sampling techniques. Solid-phase microextraction (SPME) methods have been developed, offering quick, undemanding, noninvasive sampling without the use of solvents. In this study, time-weighted average SPME (TWA-SPME) sampling was evaluated for in planta quantification of chlorinated solvents. TWA-SPME was found to have increased sensitivity over headspace and equilibrium SPME sampling. Using a variety of chlorinated solvents and a polydimethylsiloxane/carboxen (PDMS/CAR) SPME fiber, most compounds exhibited near linear or linear uptake over the sampling period. Smaller, less hydrophobic compounds exhibited more nonlinearity than larger, more hydrophobic molecules. Using a specifically designed in planta sampler, field sampling was conducted at a site contaminated with chlorinated solvents. Sampling with TWA-SPME produced instrument responses ranging from 5 to over 200 times higher than headspace tree core sampling. This work demonstrates that TWA-SPME can be used for in planta detection of a broad range of chlorinated solvents and methods can likely be applied to other volatile and semivolatile organic compounds.
    Mesh-Begriff(e) Dimethylpolysiloxanes ; Environmental Monitoring/instrumentation ; Environmental Monitoring/methods ; Environmental Pollutants/analysis ; Hydrocarbons, Chlorinated/analysis ; Solid Phase Microextraction ; Solvents/analysis ; Trees ; Volatile Organic Compounds/analysis
    Chemische Substanzen Dimethylpolysiloxanes ; Environmental Pollutants ; Hydrocarbons, Chlorinated ; Solvents ; Volatile Organic Compounds ; baysilon (63148-62-9)
    Sprache Englisch
    Erscheinungsdatum 2012-03-20
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/es2041898
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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