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  1. Artikel ; Online: Fabrication of triple-crosslinked gelatin/alginate hydrogels for controlled release applications

    Shen, Ke-Han / Chiu, Ting-Hsiang / Teng, Kuang-Chih / Yu, Jiashing / Yeh, Yi-Cheun

    International Journal of Biological Macromolecules. 2023 Aug. 03, p.126133-

    2023  , Seite(n) 126133–

    Abstract: Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and ...

    Abstract Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and weak mechanical property of the hydrogels. Here, phenylboronic acid-grafted polyethyleneimine (PBA-PEI)-modified gelatin (PPG) was synthesized to crosslink alginate dialdehyde (ADA) through imine bonds and boronate ester bonds, and then calcium ions (Ca²⁺) were added to introduce the third calcium-carboxylate crosslinking in the network to form the triple-crosslinked PPG/ADA + Ca²⁺ hydrogels. Given the three types of dynamic bonds in the network, PPG/ADA + Ca²⁺ hydrogels possessed a self-healing manner, stimuli-responsiveness, and better mechanical properties compared to single- or double-crosslinked hydrogels. The controlled release capability of PPG/ADA + Ca²⁺ hydrogels was also demonstrated, showing the encapsulated molecules can be rapidly released from the hydrogel network in the presence of hydrogen peroxide while the release rate can be slowed down at acidic pH. Furthermore, PPG/ADA + Ca²⁺ hydrogels presented selected cytotoxicity and drug delivery to cancer cells due to the regulated degradation by the cellular microenvironment. Taken together, PPG/ADA + Ca²⁺ hydrogels have been demonstrated as promising biomaterials with multiple desirable properties and dynamic features to perform controlled molecule release for biomedical applications.
    Schlagwörter alginates ; biocompatible materials ; calcium ; cancer therapy ; cellular microenvironment ; crosslinking ; cytotoxicity ; drugs ; encapsulation ; gelatin ; hydrogels ; hydrogen peroxide ; imines ; mechanical properties ; neoplasms ; pH ; polyethyleneimine ; Alginate ; Dynamic bonds
    Sprache Englisch
    Erscheinungsverlauf 2023-0803
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    Anmerkung Pre-press version
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.126133
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel ; Online: Fabrication of triple-crosslinked gelatin/alginate hydrogels for controlled release applications.

    Shen, Ke-Han / Chiu, Ting-Hsiang / Teng, Kuang-Chih / Yu, Jiashing / Yeh, Yi-Cheun

    International journal of biological macromolecules

    2023  Band 250, Seite(n) 126133

    Abstract: Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and ...

    Abstract Hydrogels have been demonstrated as smart drug carriers to recognize the tumor microenvironment for cancer treatment, where the dynamic crosslinks in the hydrogel network contribute to the stimuli-responsive features but also result in poor stability and weak mechanical property of the hydrogels. Here, phenylboronic acid-grafted polyethyleneimine (PBA-PEI)-modified gelatin (PPG) was synthesized to crosslink alginate dialdehyde (ADA) through imine bonds and boronate ester bonds, and then calcium ions (Ca
    Sprache Englisch
    Erscheinungsdatum 2023-08-03
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2023.126133
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2374: Hefte anzeigen Standort:
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  3. Artikel ; Online: Dual Dynamic Covalently Crosslinked Alginate Hydrogels with Tunable Properties and Multiple Stimuli-Responsiveness.

    Shen, Ke-Han / Yeh, Ying-Yu / Chiu, Ting-Hsiang / Wang, Reuben / Yeh, Yi-Cheun

    ACS biomaterials science & engineering

    2022  Band 8, Heft 10, Seite(n) 4249–4261

    Abstract: Alginate is a biopolymer that can be crosslinked with calcium ions to fabricate cytocompatible hydrogels. However, using calcium ions to crosslink alginate provides limited properties and functions to alginate hydrogels, restricting their biomedical ... ...

    Abstract Alginate is a biopolymer that can be crosslinked with calcium ions to fabricate cytocompatible hydrogels. However, using calcium ions to crosslink alginate provides limited properties and functions to alginate hydrogels, restricting their biomedical applications. Here, phenylboronic acid-functionalized polyethyleneimine (PBA-PEI) was developed to introduce two orthogonal dynamic covalent crosslinks in the alginate hydrogels, where PBA-PEI was used to crosslink alginate dialdehyde (ADA) through imine bonds and boronate ester bonds. The grafting degree of PBA in the PEI structure was applied to fine-tune the properties of PBA-PEI/ADA hydrogels, including the rheological property, mechanical strength, swelling behavior, and antibacterial activity. In particular, the highly sensitive boronate ester bonds in the network enabled PBA-PEI/ADA hydrogels to be responsive to several stimuli, such as glucose, fructose, and hydrogen peroxide. Taken together, PBA-PEI/ADA hydrogels with tunable properties and multiple stimuli-responsiveness have been demonstrated as smart biomaterials for advanced biomedical applications.
    Mesh-Begriff(e) Alginates/chemistry ; Alginates/pharmacology ; Anti-Bacterial Agents ; Biocompatible Materials/pharmacology ; Calcium/chemistry ; Esters ; Fructose ; Glucose ; Hydrogels/chemistry ; Hydrogels/pharmacology ; Hydrogen Peroxide/pharmacology ; Polyethyleneimine/pharmacology
    Chemische Substanzen Alginates ; Anti-Bacterial Agents ; Biocompatible Materials ; Esters ; Hydrogels ; Fructose (30237-26-4) ; Polyethyleneimine (9002-98-6) ; Hydrogen Peroxide (BBX060AN9V) ; Glucose (IY9XDZ35W2) ; Calcium (SY7Q814VUP)
    Sprache Englisch
    Erscheinungsdatum 2022-09-29
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2373-9878
    ISSN (online) 2373-9878
    DOI 10.1021/acsbiomaterials.2c00571
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics.

    Shen, Ke-Han / Lu, Cheng-Hsun / Kuo, Chih-Yu / Li, Bo-Yan / Yeh, Yi-Cheun

    Journal of materials chemistry. B

    2021  Band 9, Heft 35, Seite(n) 7100–7116

    Abstract: Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the ... ...

    Abstract Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects.
    Mesh-Begriff(e) Biocompatible Materials/chemical synthesis ; Biocompatible Materials/chemistry ; Biocompatible Materials/therapeutic use ; Hydrogels/chemical synthesis ; Hydrogels/chemistry ; Hydrogels/therapeutic use ; Infrared Rays ; Materials Testing ; Nanocomposites/chemistry ; Nanocomposites/therapeutic use
    Chemische Substanzen Biocompatible Materials ; Hydrogels
    Sprache Englisch
    Erscheinungsdatum 2021-09-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d1tb00980j
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  5. Artikel: Smart near infrared-responsive nanocomposite hydrogels for therapeutics and diagnostics

    Shen, Ke-Han / Lu, Cheng-Hsun / Kuo, Chih-Yu / Li, Bo-Yan / Yeh, Yi-Cheun

    Journal of materials chemistry B. 2021 Sept. 15, v. 9, no. 35

    2021  

    Abstract: Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the ... ...

    Abstract Nanocomposite (NC) hydrogels are emerging biomaterials that possess desirable and defined properties and functions for therapeutics and diagnostics. Particularly, nanoparticles (NPs) are employed as stimulus-transducers in NC hydrogels to facilitate the treatment process by providing controllable structural change and payload release under internal and external simulations. Among the various external stimuli, near-infrared (NIR) light has attracted considerable interest due to its minimal photo-damage, deep tissue penetration, low auto-fluorescence in living systems, facile on/off switch, easy remote and spatiotemporal control. In this study, we discuss four types of transducing nanomaterials used in NIR-responsive NC hydrogels, including metal-based nanoparticles, carbon-based nanomaterials, polydopamine nanoparticles (PDA NPs), and upconversion nanoparticles (UCNPs). This review provides an overview of the current progress in NIR-responsive NC hydrogels, focusing on their preparation, properties, applications, and future prospects.
    Schlagwörter biocompatible materials ; diagnostic techniques ; hydrogels ; nanocomposites ; therapeutics
    Sprache Englisch
    Erscheinungsverlauf 2021-0915
    Umfang p. 7100-7116.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d1tb00980j
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  6. Artikel: In situ formation of nanocomposite double-network hydrogels with shear-thinning and self-healing properties

    Tsai, Tsan-Yu / Shen, Ke-Han / Chang, Chun-Wei / Jovanska, Lavernchy / Wang, Reuben / Yeh, Yi-Cheun

    Biomaterials science. 2021 Feb. 9, v. 9, no. 3

    2021  

    Abstract: Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges ... ...

    Abstract Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges remain, including the time-consuming preparation and the lack of shear-thinning and self-healing properties. Here, our approach to developing versatile ncDN hydrogels is through the use of multiple interfacial crosslinking chemistries (i.e., noncovalent interactions of electrostatic interaction and hydrogen bonds as well as dynamic covalent interactions of imine bonds and boronate ester bonds) and surface functionalized nanomaterials (i.e. phenylboronic acid modified reduced graphene oxide (PBA-rGO)). PBA-rGO was used as a multivalent gelator to further crosslink the two polymer chains (i.e. triethylene glycol-grafted chitosan (TEG-CS) and polydextran aldehyde (PDA)) in DN hydrogels, forming the TEG-CS/PDA/PBA-rGO ncDN hydrogels in seconds. The microstructures (i.e. pore size) and properties (i.e. rheological, mechanical, and swelling properties) of the ncDN hydrogels can be simply modulated by changing the amount of PBA-rGO. The dynamic bonds in the polymeric network provided the shear-thinning and self-healing properties to the ncDN hydrogels, allowing the hydrogels to be injected and molded into varied shapes as well as self-repair the damaged structure. Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together, we hereby provide a nanomaterial approach to fabricate a new class of ncDN hydrogels with tailorable networks and favorite properties for specific applications.
    Schlagwörter aldehydes ; antibacterial properties ; biocompatible materials ; chitosan ; crosslinking ; electrostatic interactions ; graphene oxide ; hydrogels ; hydrogen ; imines ; nanocomposites ; phenylboronic acids ; polymers ; porosity
    Sprache Englisch
    Erscheinungsverlauf 2021-0209
    Umfang p. 985-999.
    Erscheinungsort The Royal Society of Chemistry
    Dokumenttyp Artikel
    Anmerkung NAL-AP-2-clean
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01528h
    Datenquelle NAL Katalog (AGRICOLA)

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  7. Artikel ; Online: In situ

    Tsai, Tsan-Yu / Shen, Ke-Han / Chang, Chun-Wei / Jovanska, Lavernchy / Wang, Reuben / Yeh, Yi-Cheun

    Biomaterials science

    2020  Band 9, Heft 3, Seite(n) 985–999

    Abstract: Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges ... ...

    Abstract Nanocomposite double-network hydrogels (ncDN hydrogels) are recently introduced to address the limitations of traditional DN hydrogels, such as the lack of diversity in the network structure and the restricted functionalities. However, two challenges remain, including the time-consuming preparation and the lack of shear-thinning and self-healing properties. Here, our approach to developing versatile ncDN hydrogels is through the use of multiple interfacial crosslinking chemistries (i.e., noncovalent interactions of electrostatic interaction and hydrogen bonds as well as dynamic covalent interactions of imine bonds and boronate ester bonds) and surface functionalized nanomaterials (i.e. phenylboronic acid modified reduced graphene oxide (PBA-rGO)). PBA-rGO was used as a multivalent gelator to further crosslink the two polymer chains (i.e. triethylene glycol-grafted chitosan (TEG-CS) and polydextran aldehyde (PDA)) in DN hydrogels, forming the TEG-CS/PDA/PBA-rGO ncDN hydrogels in seconds. The microstructures (i.e. pore size) and properties (i.e. rheological, mechanical, and swelling properties) of the ncDN hydrogels can be simply modulated by changing the amount of PBA-rGO. The dynamic bonds in the polymeric network provided the shear-thinning and self-healing properties to the ncDN hydrogels, allowing the hydrogels to be injected and molded into varied shapes as well as self-repair the damaged structure. Besides, the designed TEG-CS/PDA/PBA-rGO ncDN hydrogels were cytocompatible and also exhibited antibacterial activity. Taken together, we hereby provide a nanomaterial approach to fabricate a new class of ncDN hydrogels with tailorable networks and favorite properties for specific applications.
    Mesh-Begriff(e) Hydrogels ; Hydrogen Bonding ; Nanocomposites ; Polymers
    Chemische Substanzen Hydrogels ; Polymers
    Sprache Englisch
    Erscheinungsdatum 2020-12-10
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2693928-9
    ISSN 2047-4849 ; 2047-4830
    ISSN (online) 2047-4849
    ISSN 2047-4830
    DOI 10.1039/d0bm01528h
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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