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  1. Artikel ; Online: 52-year-old man • intermittent fevers • recently received second dose of COVID-19 vaccine • tremors in all 4 extremities • Dx?

    Lear, Aaron / Itrat, Ahmed / Sheridan, Katherine C

    The Journal of family practice

    2023  Band 72, Heft 8, Seite(n) 345–347

    Abstract: intermittent fevers ► recently received second dose of COVID-19 vaccine ► tremors in all 4 extremities. ...

    Abstract ► intermittent fevers ► recently received second dose of COVID-19 vaccine ► tremors in all 4 extremities.
    Mesh-Begriff(e) Humans ; Male ; COVID-19/prevention & control ; COVID-19 Vaccines/adverse effects ; Extremities ; Tremor/chemically induced ; Middle Aged
    Chemische Substanzen COVID-19 Vaccines
    Sprache Englisch
    Erscheinungsdatum 2023-10-20
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 197883-4
    ISSN 1533-7294 ; 0094-3509
    ISSN (online) 1533-7294
    ISSN 0094-3509
    DOI 10.12788/jfp.0669
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Community-Centered User Research for the Development of the WHO's Epidemic and Pandemic Preparedness Platform, the Hive.

    Briand, Sylvie / Hess, Sarah / Lee, John / Sheridan, Katherine / Nguyen, Tim / Yau, Brian

    Studies in health technology and informatics

    2023  Band 305, Seite(n) 394–397

    Abstract: Each epidemic and pandemic is accompanied by an infodemic. The infodemic during the COVID-19 pandemic was unprecedented. Accessing accurate information was difficult and misinformation harmed the pandemic response, the health of individuals and trust in ... ...

    Abstract Each epidemic and pandemic is accompanied by an infodemic. The infodemic during the COVID-19 pandemic was unprecedented. Accessing accurate information was difficult and misinformation harmed the pandemic response, the health of individuals and trust in science, governments and societies. WHO is building a community-centered information platform, the Hive, to deliver on the vision of ensuring that all people everywhere have access to the right information, at the right time, in the right format in order to make decisions to protect their health and the health of others. The platform provides a safe space for knowledge-sharing, discussion, collaboration, and access to credible information. The Hive platform is an innovative minimum viable product that seeks to leverage the complex information ecosystem and the invaluable role of communities to share and access trustworthy health information during epidemics and pandemics.
    Mesh-Begriff(e) Humans ; Pandemics ; Ecosystem ; COVID-19/epidemiology ; Access to Information ; World Health Organization
    Sprache Englisch
    Erscheinungsdatum 2023-06-29
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230514
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: WHO's Community-Centered Epidemic and Pandemic Information Platform: Hive.

    Briand, Sylvie / Hess, Sarah / Lee, John / Sheridan, Katherine / Nguyen, Tim / Yau, Brian

    Studies in health technology and informatics

    2023  Band 302, Seite(n) 83–87

    Abstract: Each epidemic and pandemic is accompanied by an infodemic. The infodemic during the COVID-19 pandemic was unprecedented. Accessing accurate information was difficult and misinformation harmed the pandemic response, the health of individuals and trust in ... ...

    Abstract Each epidemic and pandemic is accompanied by an infodemic. The infodemic during the COVID-19 pandemic was unprecedented. Accessing accurate information was difficult and misinformation harmed the pandemic response, the health of individuals and trust in science, governments and societies. WHO is building a community-centered information platform, the Hive, to deliver on the vision of ensuring that all people everywhere have access to the right information, at the right time, in the right format in order to make decisions to protect their health and the health of others. The platform provides access to credible information, a safe space for knowledge-sharing, discussion, and collaborating with others, and a forum to crowdsource solutions to problems. The platform is equipped with many collaboration features, including instant chats, event management, and data analytics tools to generate insights. The Hive platform is an innovative minimum viable product (MVP) that seeks to leverage the complex information ecosystem and the invaluable role communities play to share and access trustworthy health information during epidemics and pandemics.
    Mesh-Begriff(e) Humans ; Pandemics ; COVID-19/epidemiology ; SARS-CoV-2 ; Ecosystem ; World Health Organization
    Sprache Englisch
    Erscheinungsdatum 2023-05-18
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ISSN 1879-8365
    ISSN (online) 1879-8365
    DOI 10.3233/SHTI230069
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: The intestinal microbiome of children with initial and recurrent nephrolithiasis: A pilot study and exploratory analysis.

    Ellison, Jonathan S / Atkinson, Samantha N / Hayward, Mike / Hokanson, Elise / Sheridan, Katherine R / Salzman, Nita

    Journal of pediatric urology

    2023  Band 20, Heft 1, Seite(n) 18–25

    Abstract: Introduction: Kidney stone disease in children is rising disproportionate to the general population, representing a disease population with a distinct biological mechanism as compared to adults. Factors influencing recurrent kidney stone disease in ... ...

    Abstract Introduction: Kidney stone disease in children is rising disproportionate to the general population, representing a disease population with a distinct biological mechanism as compared to adults. Factors influencing recurrent kidney stone disease in children are poorly characterized and the associations of the intestinal microbiome within sub-populations of kidney stone formers, however, are not well described. We evaluated a pilot cohort of children with nephrolithiasis comparing patients based on recurrent kidney stone episodes and abnormal 24-h urinary parameters, with dual aims to compare the microbiome signal in children with initial and recurrent nephrolithiasis and to explore additional associations in microbiome composition and diversity within this population.
    Methods: Children aged 6-18 with a history of nephrolithiasis, without an active ureteral calculus or antibiotic exposure within 30 days of study entry were eligible to participate. All participants had a 24-h urine study within 6 months of study entry and provided a fecal sample. Microbiome samples were analyzed using 16S ribosomal DNA sequencing techniques for alpha and beta diversity comparing initial and recurrent stone formers as well as microbiome multivariate association (MaAsLin2) to determine differentially abundant taxa. Shotgun sequencing reads were aligned to custom oxidase degradation and butyrate production gene databases (5 databases total). Comparisons for MaAsLin2 and shotgun metagenomics, normalized to sequencing depth, were based on stone recurrence, sex, hypercalcuria (≤4 mg/kg/day), hyperoxaluria (≥45 mg/1.73 m
    Results: A total of 16 enrolled children provided samples sufficient for analyses, including 9 girls and 7 boys, of whom 5 had experienced recurrent kidney stone events. Three participants had hypercalcuria, 2 had hyperoxaluria, and 4 had hypocitraturia. Comparisons of Formyl-CoA transferase between index and recurrent urinary stone disease revealed a trend towards higher mean abundance of the gene in initial stone formers (0.166% vs 0.0343%, p = 0.2847) (Summary Figure), while trends toward lower biodiversity were also noted in the recurrent stone cohort on both Faith (p = 0.06) and Shannon (p = 0.05) indices. Exploratory analyses found Eubacterium siraeum to be significantly greater in relative abundance in children with documented hypercalciuria (p = 0.001).
    Discussion: Our pilot study demonstrates possible signals in both microbial diversity and oxalate gene expression, both of which are lower in recurrent pediatric kidney stone patients. These findings warrant further investigation as a potential diagnostic marker for future kidney stone events.
    Mesh-Begriff(e) Adult ; Male ; Female ; Humans ; Child ; Pilot Projects ; Gastrointestinal Microbiome ; Nephrolithiasis/epidemiology ; Kidney Calculi ; Urolithiasis/epidemiology ; Hyperoxaluria ; Recurrence ; Risk Factors
    Sprache Englisch
    Erscheinungsdatum 2023-09-22
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2237683-5
    ISSN 1873-4898 ; 1477-5131
    ISSN (online) 1873-4898
    ISSN 1477-5131
    DOI 10.1016/j.jpurol.2023.09.015
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Volltext online

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 6387: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  5. Artikel: Concurrent renal-cell carcinoma and cutaneous leiomyomas: A case of HLRCC.

    Fondriest, Sara A / Gowdy, John M / Goyal, Manish / Sheridan, Katherine C / Wasdahl, Daniel A

    Radiology case reports

    2015  Band 10, Heft 1, Seite(n) 962

    Abstract: A 51-year-old Caucasian female presenting with renal-cell cancer and cutaneous leiomyomas was later diagnosed with Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome. HLRCC is an autosomal dominant condition caused by a mutation in the ... ...

    Abstract A 51-year-old Caucasian female presenting with renal-cell cancer and cutaneous leiomyomas was later diagnosed with Hereditary Leiomyomatosis and Renal Cell Cancer (HLRCC) Syndrome. HLRCC is an autosomal dominant condition caused by a mutation in the fumarate hydratase gene, which encodes for an enzyme in the citric acid cycle. This syndrome has been reported in over 100 families throughout the world, the majority of whom are of Eastern European descent. Those with this syndrome have a significantly increased risk of developing renal-cell carcinoma, cutaneous leiomyomas, and uterine leiomyomas, and a smaller chance of developing uterine leiomyosarcomas. This syndrome has a relatively poor prognosis, with tumor metastasis occurring in approximately 50% of patients. However, more aggressive prophylactic measures and recent studies have shown potential to improve patient prognosis.
    Sprache Englisch
    Erscheinungsdatum 2015-12-03
    Erscheinungsland Netherlands
    Dokumenttyp Case Reports
    ZDB-ID 2406300-9
    ISSN 1930-0433
    ISSN 1930-0433
    DOI 10.2484/rcr.v10i1.962
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  6. Artikel ; Online: The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.

    Bebee, Thomas W / Park, Juw Won / Sheridan, Katherine I / Warzecha, Claude C / Cieply, Benjamin W / Rohacek, Alex M / Xing, Yi / Carstens, Russ P

    eLife

    2015  Band 4

    Abstract: Tissue- and cell-type-specific regulators of alternative splicing (AS) are essential components of posttranscriptional gene regulation, necessary for normal cellular function, patterning, and development. Mice with ablation of Epithelial splicing ... ...

    Abstract Tissue- and cell-type-specific regulators of alternative splicing (AS) are essential components of posttranscriptional gene regulation, necessary for normal cellular function, patterning, and development. Mice with ablation of Epithelial splicing regulatory protein (Esrp1) develop cleft lip and palate. Loss of both Esrp1 and its paralog Esrp2 results in widespread developmental defects with broad implications to human disease. Deletion of the Esrps in the epidermis revealed their requirement for establishing a proper skin barrier, a primary function of epithelial cells comprising the epidermis. We profiled the global Esrp-mediated splicing regulatory program in epidermis, which revealed large-scale programs of epithelial cell-type-specific splicing required for epithelial cell functions. These mice represent a valuable model for evaluating the essential role for AS in development and function of epithelial cells, which play essential roles in tissue homeostasis in numerous organs, and provide a genetic tool to evaluate important functional properties of epithelial-specific splice variants in vivo.
    Mesh-Begriff(e) Animal Structures/embryology ; Animals ; Epithelial Cells/physiology ; Female ; Gene Deletion ; Gene Expression Profiling ; Male ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; RNA-Binding Proteins/genetics ; RNA-Binding Proteins/metabolism
    Chemische Substanzen ESRP1 protein, mouse ; ESRP2 protein, mouse ; RNA-Binding Proteins
    Sprache Englisch
    Erscheinungsdatum 2015-09-15
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.08954
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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