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  1. Artikel: Clinical effect of high-flow nasal cannula oxygen therapy combined with naloxone on severe respiratory failure in older adult patients: a randomized controlled trial.

    Zhou, Yaqing / Shi, Xiaoyan / Pu, Zunguo / Liu, Aiming

    American journal of translational research

    2023  Band 15, Heft 11, Seite(n) 6613–6620

    Abstract: Objective: To analyze the clinical effect of high-flow nasal cannula (HFNC) oxygen therapy combined with naloxone on severe respiratory failure (SRF) in older adult patients.: Methods: We enrolled 96 older adult patients with SRF who were admitted to ...

    Abstract Objective: To analyze the clinical effect of high-flow nasal cannula (HFNC) oxygen therapy combined with naloxone on severe respiratory failure (SRF) in older adult patients.
    Methods: We enrolled 96 older adult patients with SRF who were admitted to Hai'an People's Hospital between February 2019 and March 2022. The patients were divided into two groups: the control group (treated with non-invasive positive pressure ventilation combined with naloxone) and the observation group (treated with HFNC oxygen therapy combined with naloxone). The blood gas measurement, respiratory rate (RR), St. George's Respiratory Questionnaire (SGRQ) score, Clara cell secreted protein (CC16) level, tumor necrosis factor-alpha (TNF-α) level, interleukin-1 (IL-1) level, length of intensive care unit (ICU) stay, tracheal intubation rate, and 28-day mortality rate were compared between the groups.
    Results: Blood gas measurement or RR did not differ significantly between the groups (
    Conclusions: HFNC oxygen therapy combined with naloxone in older adult patients with SRF could improve blood gas results, disease duration, tracheal intubation rate, and 28-day mortality rate. This may occur through regulation of TNF-α, IL-1, and CC16 expression.
    Sprache Englisch
    Erscheinungsdatum 2023-11-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  2. Artikel ; Online: Numerical simulation study on optimization of ventilation airflow organization of a raw coal bunker

    Zhang Qianru / Yang Luying / Shi Xiaoyan / Wang Xin

    E3S Web of Conferences, Vol 356, p

    2022  Band 01061

    Abstract: For the problem of gas accumulation in the product bunker of a company’s coal processing plant, three different ventilation schemes are proposed. The first one opens rectangular air inlet louvers on the wall of the product bunker and adds fans on the top ...

    Abstract For the problem of gas accumulation in the product bunker of a company’s coal processing plant, three different ventilation schemes are proposed. The first one opens rectangular air inlet louvers on the wall of the product bunker and adds fans on the top for exhaust; the second one sets six ventilation windows evenly on the top of the product bunker for natural ventilation; the third one sends air to the interior of the bunker through small holes evenly distributed on the ventilation pipes and opens six exhaust ports on the wall. Finally, the effect of gas accumulation management of the ventilation scheme is simulated and analyzed through numerical simulation. The ventilation scheme is applicable to the gas accumulation management of raw coal bunkers with different coal storage heights, and provides a technical reference for the gas accumulation management of product bunkers in coal processing plants.
    Schlagwörter Environmental sciences ; GE1-350
    Thema/Rubrik (Code) 690
    Sprache Englisch
    Erscheinungsdatum 2022-01-01T00:00:00Z
    Verlag EDP Sciences
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: Paeonol Attenuates Atherosclerosis by Inhibiting Vascular Smooth Muscle Cells Senescence via SIRT1/P53/TRF2 Signaling Pathway.

    Zhou, Min / Ma, Xiaolin / Gao, Menglong / Wu, Hongfei / Liu, Yarong / Shi, Xiaoyan / Dai, Min

    Molecules (Basel, Switzerland)

    2024  Band 29, Heft 1

    Abstract: Atherosclerosis is a chronic inflammatory disease leading to various vascular diseases. Vascular smooth muscle cell (VSMC) senescence promotes atherosclerotic inflammation and the formation of plaque necrosis core, in part through telomere damage ... ...

    Abstract Atherosclerosis is a chronic inflammatory disease leading to various vascular diseases. Vascular smooth muscle cell (VSMC) senescence promotes atherosclerotic inflammation and the formation of plaque necrosis core, in part through telomere damage mediated by a high-fat diet. Our previous research found that paeonol, a potential anti-inflammatory agent extracted from Cortex Moutan, could significantly improve VSMCs dysfunction. However, the impact of paeonol on the senescence of VSMCs remains unexplored. This study presents the protective effects of paeonol on VSMCs senescence, and its potential activity in inhibiting the progression of atherosclerosis in vivo and in vitro. Sirtuin 1 (SIRT1) is a nuclear deacetylase involved in cell proliferation, senescence, telomere damage, and inflammation. Here, SIRT1 was identified as a potential target of paeonol having anti-senescence and anti-atherosclerosis activity. Mechanistic studies revealed that paeonol binds directly to SIRT1 and then activates the SIRT1/P53/TRF2 pathway to inhibit VSMCs senescence. Our results suggested that SIRT1-mediated VSMCs senescence is a promising druggable target for atherosclerosis, and that pharmacological modulation of the SIRT1/P53/TRF2 signaling pathway by paeonol is of potential benefit for patients with atherosclerosis.
    Mesh-Begriff(e) Humans ; Sirtuins ; Sirtuin 1 ; Muscle, Smooth, Vascular ; Tumor Suppressor Protein p53 ; Atherosclerosis/drug therapy ; Inflammation ; Signal Transduction ; Acetophenones
    Chemische Substanzen Sirtuins (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; paeonol (3R834EPI82) ; Tumor Suppressor Protein p53 ; SIRT1 protein, human (EC 3.5.1.-) ; Acetophenones
    Sprache Englisch
    Erscheinungsdatum 2024-01-04
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29010261
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  4. Artikel: Clinical Analysis of Lacosamide Monotherapy in the Treatment of Self-Limited Epilepsy with Centrotemporal Spikes.

    Feng, Jun / Zhang, Liya / Tang, Jihong / Zhang, Bingbing / Xiao, Xiao / Shi, Xiaoyan

    Neuropsychiatric disease and treatment

    2024  Band 20, Seite(n) 459–467

    Abstract: Objective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS).: Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in ... ...

    Abstract Objective: To evaluate the efficacy and safety of lacosamide (LCM) monotherapy in the treatment of self-limited epilepsy with centrotemporal spikes (SeLECTS).
    Methods: In this study, 89 children with SeLECTS who were treated with LCM monotherapy in the Children's Hospital Affiliated to Soochow University from June 2019 to June 2021 were included. Clinical seizures and spike wave index (SWI) on video EEG during slow-wave sleep were evaluated before and after treatment. The role of LCM monotherapy in improving SWI, controlling clinical seizures and improving cognition was analyzed, and corresponding adverse reactions were documented.
    Results: There were 52 males and 37 females in this group, with an average age of 7.6 ± 2.1 years. The total effective rate was 93.83% and at 18 months of treatment, the cumulative control rate was 85.19%, the retention rate was 91.01% and the effective rate in terms of EEG spike index was 72.92%, all of which showed a high rate; there was no statistically significant difference in intelligence quotient before and after treatment (
    Conclusion: LCM monotherapy had curative effect and adverse reactions for SeLECTS, with no negative impact on cognition. These significant findings indicate that LCM is likely to become a widely prescribed ASM for the treatment of SeLECTS. Meanwhile, the onset age and baseline seizure frequency had certain value in judging prognosis and predicting curative effect.
    Sprache Englisch
    Erscheinungsdatum 2024-03-04
    Erscheinungsland New Zealand
    Dokumenttyp Journal Article
    ZDB-ID 2186503-6
    ISSN 1178-2021 ; 1176-6328
    ISSN (online) 1178-2021
    ISSN 1176-6328
    DOI 10.2147/NDT.S452784
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  5. Artikel ; Online: Creating Atomically Iridium-Doped PdO

    Wang, Yingjie / Xu, Guangyan / Sun, Yanwei / Shi, Wei / Shi, Xiaoyan / Yu, Yunbo / He, Hong

    Environmental science & technology

    2024  

    Abstract: The urgent environmental concern of methane abatement, attributed to its high global warming potential, necessitates the development of methane oxidation catalysts (MOC) with enhanced low-temperature activity and durability. Herein, an iridium-doped ... ...

    Abstract The urgent environmental concern of methane abatement, attributed to its high global warming potential, necessitates the development of methane oxidation catalysts (MOC) with enhanced low-temperature activity and durability. Herein, an iridium-doped PdO
    Sprache Englisch
    Erscheinungsdatum 2024-05-10
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.4c00868
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  6. Artikel ; Online: MicroRNA let-7g links foam cell formation and adipogenic differentiation: A key regulator of Paeonol treating atherosclerosis-osteoporosis.

    Yan, Jinjin / Yang, Yulong / Liu, Yarong / Shi, Xiaoyan / Wu, Hongfei / Dai, Min

    Phytomedicine : international journal of phytotherapy and phytopharmacology

    2024  Band 126, Seite(n) 155447

    Abstract: Backgroud: High comorbidity rates have been reported in patients with atherosclerosis and osteoporosis, posing a serious risk to the health and well-being of elderly patients. To improve and update clinical practice regarding the joint treatment of ... ...

    Abstract Backgroud: High comorbidity rates have been reported in patients with atherosclerosis and osteoporosis, posing a serious risk to the health and well-being of elderly patients. To improve and update clinical practice regarding the joint treatment of these two diseases, the common mechanisms of atherosclerosis and osteoporosis need to be clarified. MicroRNAs (miRNAs), are importance molecules in the pathogenesis of human diseases, including in cardiovascular and orthopedic fields. They have garnered interest as potential targets for novel therapeutic strategies. However, the key miRNAs involved in atherosclerosis and osteoporosis and their precise regulation mechanisms remain unknown. Paeonol (Pae), an active ingredient in Cortex Moutan, has shown promising results in improving both lipid and bone metabolic abnormalities. However, it is uncertain whether this agent can exert a cotherapeutic effect on atherosclerosis and osteoporosis.
    Objective: This study aimed to screen important shared miRNAs in atherosclerotic and osteoporotic complications, and explore the mechanism of the protective effects of Pae against atherosclerosis and osteoporosis in high-fat diet (HFD)-fed ApoE
    Methods: An experimental atherosclerosis and osteoporosis model was established in 40-week-old HFD ApoE
    Results: miR let-7g identified using bioinformatics was assessed to evaluate its participation in atherosclerosis-osteoporosis. Experimental analysis showed reduced miR let-7g levels in the atherosclerosis-osteoporosis mice model. Moreover, miR let-7g was required for BMSC - Raw 264.7 cell crosstalk, thereby promoting foam cell formation and adipocyte differentiation. Treatment with Pae significantly reduced plaque accumulation and foam cell number in the aorta while increasing bone density and improving trabecular bone microarchitecture in HFD ApoE
    Conclusion: The study results suggested that miR let-7g participates in atherosclerosis -osteoporosis regulation and that Pae acts as a potential therapeutic agent for preventing atherosclerosis-osteoporosis through regulatory effects on the miR let-7g/HMGA2/CEBPβ pathway to hinder foam cell formation and adipocyte differentiation.
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Aged ; Foam Cells ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/metabolism ; Cell Differentiation ; Osteoporosis/drug therapy ; Osteoporosis/metabolism ; Apolipoproteins E/genetics ; Acetophenones
    Chemische Substanzen paeonol (3R834EPI82) ; MicroRNAs ; Apolipoproteins E ; Acetophenones
    Sprache Englisch
    Erscheinungsdatum 2024-02-11
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1205240-1
    ISSN 1618-095X ; 0944-7113
    ISSN (online) 1618-095X
    ISSN 0944-7113
    DOI 10.1016/j.phymed.2024.155447
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 4115: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Artikel ; Online: Metallophilic Interactions Drive Supramolecular Chirality Evolution and Amplify Circularly Polarized Luminescence.

    Wang, Ya-Jie / Shi, Xiao-Yan / Xing, Pengyao / Zang, Shuang-Quan

    JACS Au

    2023  Band 3, Heft 2, Seite(n) 565–574

    Abstract: Metallophilic interactions, which are ubiquitous among ... ...

    Abstract Metallophilic interactions, which are ubiquitous among d
    Sprache Englisch
    Erscheinungsdatum 2023-01-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.2c00653
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  8. Artikel: Effect of PDCA circulation nursing intervention on prognosis of patients with severe pneumonia.

    Bai, Ling / Yang, Likun / Shi, Xiaoyan / Huang, Wan

    American journal of translational research

    2022  Band 14, Heft 1, Seite(n) 252–263

    Abstract: Objectives: To investigate the effect of a new nursing method combining Plan-Do-Check-Act (PDCA) circulation management and nursing on the prognosis of patients with severe pneumonia.: Methods: The clinical records of 98 patients treated in the ... ...

    Abstract Objectives: To investigate the effect of a new nursing method combining Plan-Do-Check-Act (PDCA) circulation management and nursing on the prognosis of patients with severe pneumonia.
    Methods: The clinical records of 98 patients treated in the Second Affiliated Hospital of Xi'an Jiaotong University from January 2019 to January 2021 were retrospectively analyzed. Patients were divided into the control group (n=49) and the PDCA group (n=49), which were intervened by routine nursing and PDCA nursing based on routine nursing, respectively, by the same group of nursing staff.
    Results: After PDCA care, the nutritional status (body weight; total protein, TP; albumin, ALB) and immune function (immunoglobulin A, IgA; immunoglobulin G, IgG) in the PDCA group were significantly higher than those in the control group. Compared with routine nursing, PDCA care significantly increased the levels of PaO
    Conclusions: PDCA care can effectively improve the nursing quality and patients' satisfaction, and better alleviate patients' poor psychological emotions, which is conducive to building a harmonious doctor-patient relationship.
    Sprache Englisch
    Erscheinungsdatum 2022-01-15
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 2471058-1
    ISSN 1943-8141
    ISSN 1943-8141
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  9. Artikel ; Online: An Overview of Heavy Chain Ferritin in Cancer.

    Shi, Xiaoyan / Zhang, Anqi / Lu, Jinzhi / Wang, Xiaowen / Yi, Cunjian / Yang, Fuyuan

    Frontiers in bioscience (Landmark edition)

    2023  Band 28, Heft 8, Seite(n) 182

    Abstract: As a spherical protein that acts as a repository for intracellular iron, Ferritin is the most important iron storage form and is known to influence tumor immunity. Unbound ferritin is composed of 24 subunits, made up of ferritin light chain (FTL) and ... ...

    Abstract As a spherical protein that acts as a repository for intracellular iron, Ferritin is the most important iron storage form and is known to influence tumor immunity. Unbound ferritin is composed of 24 subunits, made up of ferritin light chain (FTL) and ferritin heavy chain (FTH). Ferritin can be automatically put together to form hollow nanocages that measure 12 nm around the outside and 8 nm around the inside. Cancer causes the second-most deaths worldwide, effective elimination of tumor cells while protecting normal cells is the foundation of modern tumor therapy. To this end, the innate tumor-targeting activity of human FTH1, first identified ten years ago, is highly appealing. Unmodified human FTH1 binds to its receptor, transferrin receptor 1 (TfR1), which is frequently overexpressed in cancer cells. FTH1-TfR1 binding permits improved drug efficacy by promoting ferritin-mediated targeted delivery. In addition, FTH is also associated with the prognosis of multiple typies of cancer. The level of FTH1 is significantly and positively correlated with the infiltration of tumor-associated macrophages. FTH1 also plays an important role in regulating the tumor immunity of solid cancer. As such, FTH1 has been extensively applied in the targeted delivery of anticancer drugs, diagnostic molecules (e.g., radioisotopes and fluorophones), and inorganic nanoparticles (NPs) to tumors.This article reviews the role of FTH in cancer and its potential as a therapeutic target.
    Mesh-Begriff(e) Humans ; Ferritins ; Neoplasms/drug therapy ; Iron ; Nanoparticles
    Chemische Substanzen Ferritins (9007-73-2) ; Iron (E1UOL152H7)
    Sprache Englisch
    Erscheinungsdatum 2023-07-14
    Erscheinungsland Singapore
    Dokumenttyp Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2704569-9
    ISSN 2768-6698 ; 2768-6698
    ISSN (online) 2768-6698
    ISSN 2768-6698
    DOI 10.31083/j.fbl2808182
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  10. Artikel: Metal-Organic Framework-Derived NiSe Embedded into a Porous Multi-Heteroatom Self-Doped Carbon Matrix as a Promising Anode for Sodium-Ion Battery.

    Shi, Xiaoyan / Fang, Lujun / Peng, Handong / Deng, Xizhan / Sun, Zhipeng

    Nanomaterials (Basel, Switzerland)

    2022  Band 12, Heft 19

    Abstract: A self-doping strategy is applied to prepare a multi-heteroatom-doped carbonaceous nickel selenide NiSe@C composite by introducing N and P-containing ligand hexa(4-carboxyl-phenoxy)-cyclotriphosphazene (HCTP-COOH) into a Ni-based MOF precursor. The MOF- ... ...

    Abstract A self-doping strategy is applied to prepare a multi-heteroatom-doped carbonaceous nickel selenide NiSe@C composite by introducing N and P-containing ligand hexa(4-carboxyl-phenoxy)-cyclotriphosphazene (HCTP-COOH) into a Ni-based MOF precursor. The MOF-derived NiSe@C composite is characterized as NiSe particles nested in a multi-heteroatom-doped carbon matrix. The multi-heteroatom-doped NiSe@C composite with a unique structure shows an excellent sodium-ion storage property. The Na-ion battery from the NiSe@C electrode exhibits a capacity of 447.8 mA h g
    Sprache Englisch
    Erscheinungsdatum 2022-09-26
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2662255-5
    ISSN 2079-4991
    ISSN 2079-4991
    DOI 10.3390/nano12193345
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