Article ; Online: A polyphenol fraction from Rosa multiflora var. platyphylala reduces body fat in overweight humans through appetite suppression - a randomized, double-blind, placebo-controlled trial.
BMC complementary medicine and therapies
2024 Volume 24, Issue 1, Page(s) 197
Abstract: Background: Rosa species are rich sources of polyphenols with physiological functions. In this study a polyphenol-rich Rosa multiflora (var. platyphylala) petal extract (RoseFit™) was investigated for weight loss in humans.: Methods: In a randomized, ...
Abstract | Background: Rosa species are rich sources of polyphenols with physiological functions. In this study a polyphenol-rich Rosa multiflora (var. platyphylala) petal extract (RoseFit™) was investigated for weight loss in humans. Methods: In a randomized, placebo-controlled, parallel-group, double-blind clinical trial seventy overweight male and female subjects (20-50 years) with body mass index (BMI) 25-30 kg/m Results: At the end of the study, a marked reduction in body weight (-1.20 ± 2.62 kg, p < 0.05) and BMI from baseline was observed in the RoseFit group. In addition, the body fat % (RoseFit = -1.69 ± 2.59%, placebo = 0.96 ± 3.21%; p < 0.001) and fat mass (RoseFit = -1.75 ± 1.80 kg, placebo = 1.61 ± 3.82 kg; p < 0.001) were significantly abated in RoseFit group. Importantly, the lean mass was maintained during the intervention. RoseFit ingestion significantly increased the serum leptin levels compared to the placebo (4.85%; p < 0.05). Further, RoseFit group showed reduction in the hunger hormone ghrelin level (2.27%; p < 0.001) from baseline to the end of study, compared to the placebo. The subjective evaluation of appetite using visual analog scale (VAS) questionnaires further confirmed the appetite-suppression effects of RoseFit. The lipid profile significantly improved in RoseFit-treated subjects. No serious adverse events were observed during the study, indicating the tolerability of RoseFit. Conclusions: Supplementation with RoseFit significantly impacts body weight management and can thus be a potential nutraceutical ingredient for sustainable weight loss. Trial registration: CTRI/2019/10/021584 dated 09/10/2019. |
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MeSH term(s) | Humans ; Double-Blind Method ; Rosa ; Male ; Adult ; Female ; Polyphenols/pharmacology ; Overweight/drug therapy ; Middle Aged ; Plant Extracts/pharmacology ; Young Adult ; Adipose Tissue/drug effects ; Appetite Depressants/pharmacology ; Body Mass Index |
Language | English |
Publishing date | 2024-05-21 |
Publishing country | England |
Document type | Journal Article ; Randomized Controlled Trial |
ISSN | 2662-7671 |
ISSN (online) | 2662-7671 |
DOI | 10.1186/s12906-024-04487-1 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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