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  1. Artikel ; Online: Nanoimmunosensor for the electrochemical detection of oncostatin M receptor and monoclonal autoantibodies in systemic sclerosis.

    Avelino, Karen Y P S / Silva-Junior, Alberto G / Pitta, Maira G R / Errachid, Abdelhamid / Oliveira, Maria D L / Andrade, César A S

    Talanta

    2023  Band 256, Seite(n) 124285

    Abstract: Systemic sclerosis (SSc) is a chronic, autoimmune disease that primarily affects connective tissue. SSc can be classified into limited cutaneous (lSSc) and diffuse cutaneous (dSSc). Oncostatin M receptor (sOSMR) is an important inflammatory biomarker ... ...

    Abstract Systemic sclerosis (SSc) is a chronic, autoimmune disease that primarily affects connective tissue. SSc can be classified into limited cutaneous (lSSc) and diffuse cutaneous (dSSc). Oncostatin M receptor (sOSMR) is an important inflammatory biomarker expressed in the serum of patients with autoimmune diseases. A nanoengineered immunosensor surface was developed. The biosensor was composed of a conductive layer of polypyrrole, electrodeposited gold nanoparticles, and sOSMR protein for anti-human OSMR monoclonal antibody biorecognition. The electrochemical response evaluated by cyclic voltammetry and electrochemical impedance spectroscopy indicated the detection of the target analyte present in clinical samples from lSSc and dSSc patients. The voltammetric anodic shift for lSSc specimens was 82.7% ± 0.9-93.6% ± 3.2, and dSSc specimens was 118.7 ± 2.6 to 379.6 ± 2.6, revealing a differential diagnostic character for SSc subtypes. The sensor platform was adapted for identifying sOSMR, using anti-OSMR antibodies as bioreceptors. With a linear response range estimated from 0.005 to 500 pg mL
    Mesh-Begriff(e) Humans ; Autoantibodies ; Biomarkers ; Biosensing Techniques ; Gold ; Immunoassay ; Metal Nanoparticles ; Polymers ; Pyrroles ; Receptors, Oncostatin M ; Scleroderma, Systemic/diagnosis ; Electrochemical Techniques
    Chemische Substanzen Autoantibodies ; Biomarkers ; Gold (7440-57-5) ; Polymers ; Pyrroles ; Receptors, Oncostatin M
    Sprache Englisch
    Erscheinungsdatum 2023-01-21
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2023.124285
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  2. Artikel ; Online: Electrochemical detection of gram-negative bacteria through mastoparan-capped magnetic nanoparticle.

    da Silva Junior, Alberto G / Frias, Isaac A M / Lima-Neto, Reginaldo G / Franco, Octávio L / Oliveira, Maria D L / Andrade, César A S

    Enzyme and microbial technology

    2022  Band 160, Seite(n) 110088

    Abstract: The increasing number of multidrug resistance microorganisms is an alarming threat, and their rapid detection is essential to prevent nosocomial, foodborne, or waterborne infections. Many peptides derived from the venom of wasp Synoeca surinama have ... ...

    Abstract The increasing number of multidrug resistance microorganisms is an alarming threat, and their rapid detection is essential to prevent nosocomial, foodborne, or waterborne infections. Many peptides derived from the venom of wasp Synoeca surinama have antimicrobial activity against Gram-positive and Gram-negative bacteria. Synoeca-MP, an antimicrobial peptide (AMP) from mastoparan family, seems to increase bacterial membrane permeability, promoting cytotoxicity and membrane disruption. Here Synoeca-MP was evaluated as biorecognition element tethered over chitosan-coated magnetic nanoparticles (Fe
    Mesh-Begriff(e) Adenosine Monophosphate ; Anti-Bacterial Agents/pharmacology ; Biosensing Techniques/methods ; Electrochemical Techniques/methods ; Gold/chemistry ; Gram-Negative Bacteria ; Gram-Positive Bacteria ; Intercellular Signaling Peptides and Proteins ; Magnetite Nanoparticles/chemistry ; Wasp Venoms
    Chemische Substanzen Anti-Bacterial Agents ; Intercellular Signaling Peptides and Proteins ; Magnetite Nanoparticles ; Wasp Venoms ; Adenosine Monophosphate (415SHH325A) ; mastoparan (72093-21-1) ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2022-06-20
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2022.110088
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  3. Artikel: Electrochemical detection of gram-negative bacteria through mastoparan-capped magnetic nanoparticle

    da Silva Junior, Alberto G. / Frias, Isaac A.M. / Lima-Neto, Reginaldo G. / Franco, Octávio L. / Oliveira, Maria D.L. / Andrade, César A.S.

    Enzyme and microbial technology. 2022 June 16,

    2022  

    Abstract: The increasing number of multidrug resistance microorganisms is an alarming threat, and their rapid detection is essential to prevent nosocomial, foodborne, or waterborne infections. Many peptides derived from the venom of wasp Synoeca surinama have ... ...

    Abstract The increasing number of multidrug resistance microorganisms is an alarming threat, and their rapid detection is essential to prevent nosocomial, foodborne, or waterborne infections. Many peptides derived from the venom of wasp Synoeca surinama have antimicrobial activity against Gram-positive and Gram-negative bacteria. Synoeca-MP, an antimicrobial peptide (AMP) from mastoparan family, seems to increase bacterial membrane permeability, promoting cytotoxicity and membrane disruption. Here Synoeca-MP was evaluated as biorecognition element tethered over chitosan-coated magnetic nanoparticles (Fe₃O₄-Chit). The transducing layer of the biosensor was developed from the self-assembling of 4-mercaptobenzoic acid (4-MBA) monolayer onto gold substrate. Atomic force microscopy (AFM) analyses confirmed the biointeraction between AMP and different pathogens membranes. The fabrication and performance of the biosensing assembly were characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). Detection of Enterococcus faecalis (G+), Klebsiella pneumoniae (G-), Pseudomonas aeruginosa (G-), and Candida tropicalis was assessed in a recognition range from 10¹ to 10⁵ CFU.mL⁻¹. An instrumental limit of detection of 10 CFU.mL⁻¹ was obtained for each specimen. However, the device presented a preferential selectivity towards Gram-negative bacteria. The proposed biosensor is a sensitive, fast, and straightforward platform for microbial detection in aqueous samples, envisaged for environmental monitoring applications.
    Schlagwörter Candida tropicalis ; Enterococcus faecalis ; Klebsiella pneumoniae ; Pseudomonas aeruginosa ; antimicrobial peptides ; antimicrobial properties ; atomic force microscopy ; biosensors ; cross infection ; cytotoxicity ; detection limit ; dielectric spectroscopy ; electrochemistry ; enzymes ; gold ; magnetism ; membrane permeability ; microbial detection ; multiple drug resistance ; rapid methods ; venoms ; voltammetry ; wasps
    Sprache Englisch
    Erscheinungsverlauf 2022-0616
    Erscheinungsort Elsevier Inc.
    Dokumenttyp Artikel
    Anmerkung Pre-press version
    ZDB-ID 423729-8
    ISSN 1879-0909 ; 0141-0229
    ISSN (online) 1879-0909
    ISSN 0141-0229
    DOI 10.1016/j.enzmictec.2022.110088
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  4. Artikel ; Online: Concanavalin A differentiates gram-positive bacteria through hierarchized nanostructured transducer.

    da Silva Junior, Alberto G / Frias, Isaac A M / Lima-Neto, Reginaldo G / Sá, Sandra R / Oliveira, Maria D L / Andrade, César A S

    Microbiological research

    2021  Band 251, Seite(n) 126834

    Abstract: Biosensors are pre-prepared diagnostic devices composed of at least one biological probe. These devices are envisaged for the practical identification of specific targets of microbiological interest. In recent years, the use of narrow-specific probes ... ...

    Abstract Biosensors are pre-prepared diagnostic devices composed of at least one biological probe. These devices are envisaged for the practical identification of specific targets of microbiological interest. In recent years, the use of narrow-specific probes such as lectins has been proven to distinguish bacteria and glycoproteins based on their superficial glycomic pattern. For instance, Concanavalin A is a carbohydrate-binding lectin indicated as a narrow-specific biological probe for Gram-negative bacteria. As a drawback, Gram-positive bacteria are frequently overlooked from lectin-based biosensing studies because their identification results in low resolution and overlapped signals. In this work, the authors explore the effect that platform nanostructuration has over the electrochemical response of ConA-based platforms constructed for bacterial detection; one is formed of chitosan-capped magnetic nanoparticles, and another is composed of gold nanoparticle-decorated magnetic nanoparticles. The biosensing platforms were characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) as a function of bacterial concentration. Our results show that probe-target interaction causes variations in the electrical responses of nanostructured transducers. Moreover, the association of gold nanoparticles to magnetic nanoparticles resulted in an electrical enhancement capable of overcoming low resolution and overlapping Gram-positive identification. Both platforms attained a limit of detection of 10 ° CFU mL
    Mesh-Begriff(e) Biosensing Techniques/methods ; Concanavalin A/pharmacology ; Gold ; Gram-Positive Bacteria/classification ; Gram-Positive Bacteria/drug effects ; Metal Nanoparticles ; Transducers
    Chemische Substanzen Concanavalin A (11028-71-0) ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2021-07-31
    Erscheinungsland Germany
    Dokumenttyp Journal Article
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2021.126834
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  5. Artikel: Concanavalin A differentiates gram-positive bacteria through hierarchized nanostructured transducer

    da Silva Junior, Alberto G. / Frias, Isaac A.M. / Lima-Neto, Reginaldo G. / Sá, Sandra R. / Oliveira, Maria D.L. / Andrade, César A.S.

    Microbiological research. 2021 Oct., v. 251

    2021  

    Abstract: Biosensors are pre-prepared diagnostic devices composed of at least one biological probe. These devices are envisaged for the practical identification of specific targets of microbiological interest. In recent years, the use of narrow-specific probes ... ...

    Abstract Biosensors are pre-prepared diagnostic devices composed of at least one biological probe. These devices are envisaged for the practical identification of specific targets of microbiological interest. In recent years, the use of narrow-specific probes such as lectins has been proven to distinguish bacteria and glycoproteins based on their superficial glycomic pattern. For instance, Concanavalin A is a carbohydrate-binding lectin indicated as a narrow-specific biological probe for Gram-negative bacteria. As a drawback, Gram-positive bacteria are frequently overlooked from lectin-based biosensing studies because their identification results in low resolution and overlapped signals. In this work, the authors explore the effect that platform nanostructuration has over the electrochemical response of ConA-based platforms constructed for bacterial detection; one is formed of chitosan-capped magnetic nanoparticles, and another is composed of gold nanoparticle-decorated magnetic nanoparticles. The biosensing platforms were characterized by electrochemical impedance spectroscopy (EIS) and cyclic voltammetry (CV) as a function of bacterial concentration. Our results show that probe-target interaction causes variations in the electrical responses of nanostructured transducers. Moreover, the association of gold nanoparticles to magnetic nanoparticles resulted in an electrical enhancement capable of overcoming low resolution and overlapping Gram-positive identification. Both platforms attained a limit of detection of 10 ° CFU mL⁻¹, which is useful for water analyses and sanitation concerns, where low CFU mL⁻¹ are always expected. Although both platforms were able to detect Gram-negative bacteria, Gram-positives were only correctly differentiated by the gold nanoparticle-decorated magnetic nanoparticles, thus demonstrating the positive influence of hierarchically nanostructured platforms.
    Schlagwörter biosensors ; carbohydrate binding ; concanavalin A ; detection limit ; dielectric spectroscopy ; electrochemistry ; glycomics ; glycoproteins ; gold ; magnetism ; microbial detection ; nanogold ; research ; sanitation ; voltammetry
    Sprache Englisch
    Erscheinungsverlauf 2021-10
    Erscheinungsort Elsevier GmbH
    Dokumenttyp Artikel
    ZDB-ID 1189614-0
    ISSN 1618-0623 ; 0944-5013
    ISSN (online) 1618-0623
    ISSN 0944-5013
    DOI 10.1016/j.micres.2021.126834
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  6. Artikel ; Online: Lectin-based impedimetric biosensor for differentiation of pathogenic candida species.

    Sá, Sandra R / Silva Junior, Alberto G / Lima-Neto, Reginaldo G / Andrade, Cesar A S / Oliveira, Maria D L

    Talanta

    2020  Band 220, Seite(n) 121375

    Abstract: Fungi stand out as primary pathogens present in healthcare-acquired infections, presenting an increased number of cases even using appropriate antifungal therapy. Candida spp. is a predominant microorganism among several fungal pathogens present in the ... ...

    Abstract Fungi stand out as primary pathogens present in healthcare-acquired infections, presenting an increased number of cases even using appropriate antifungal therapy. Candida spp. is a predominant microorganism among several fungal pathogens present in the healthcare setting. Candidemia and candidiasis are fungal infections responsible for high morbidity and mortality among ill patients in hospitals. It is noticeable that prolonged hospital stays lead to a higher economic impact and increased risk for developing secondary fungal or even bacterial infections. New fast and sensitive approaches for the detection of Candida species is highly required. Electrochemical biosensors are an excellent alternative to conventional techniques by combining fast analyte detection, low cost, and the possibility of miniaturization. Lectins are carbohydrate-binding proteins with the capability to reach out to the microorganism cell wall. In this work, we proposed the development of an impedimetric biosensor for Candida spp. based on Concanavalin A (ConA) and wheat germ agglutinin (WGA) as recognition agents of the yeast cells. Atomic force microscopy images indicate changes in the biosensor surface after assembly of the molecules and exposure to fungal samples. Electrochemical impedance spectroscopy results revealed a proportional increase of charge transfer resistance (R
    Mesh-Begriff(e) Antifungal Agents ; Biosensing Techniques ; Candida ; Cell Differentiation ; Humans ; Lectins ; Microbial Sensitivity Tests ; Pichia
    Chemische Substanzen Antifungal Agents ; Lectins
    Sprache Englisch
    Erscheinungsdatum 2020-07-11
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2020.121375
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  7. Artikel: Lectin-based impedimetric biosensor for differentiation of pathogenic candida species

    Sá, Sandra R / Silva Junior, Alberto G / Lima-Neto, Reginaldo G / Andrade, Cesar A.S / Oliveira, Maria D.L

    Talanta. 2020 Dec. 01, v. 220

    2020  

    Abstract: Fungi stand out as primary pathogens present in healthcare-acquired infections, presenting an increased number of cases even using appropriate antifungal therapy. Candida spp. is a predominant microorganism among several fungal pathogens present in the ... ...

    Abstract Fungi stand out as primary pathogens present in healthcare-acquired infections, presenting an increased number of cases even using appropriate antifungal therapy. Candida spp. is a predominant microorganism among several fungal pathogens present in the healthcare setting. Candidemia and candidiasis are fungal infections responsible for high morbidity and mortality among ill patients in hospitals. It is noticeable that prolonged hospital stays lead to a higher economic impact and increased risk for developing secondary fungal or even bacterial infections. New fast and sensitive approaches for the detection of Candida species is highly required. Electrochemical biosensors are an excellent alternative to conventional techniques by combining fast analyte detection, low cost, and the possibility of miniaturization. Lectins are carbohydrate-binding proteins with the capability to reach out to the microorganism cell wall. In this work, we proposed the development of an impedimetric biosensor for Candida spp. based on Concanavalin A (ConA) and wheat germ agglutinin (WGA) as recognition agents of the yeast cells. Atomic force microscopy images indicate changes in the biosensor surface after assembly of the molecules and exposure to fungal samples. Electrochemical impedance spectroscopy results revealed a proportional increase of charge transfer resistance (RCT) as fungal CFU increased, where four Candida species were evaluated (Candida krusei, Candida tropicalis, Candida parapsilosis and Candida albicans). The biosensor is useful to differentiate Candida spp. with a detection limit between 10² to 10⁶ CFU mL⁻¹. The obtained biosensor appears as an innovative candidate for the detection and differentiation of pathogenic Candida spp.
    Schlagwörter Candida albicans ; Candida krusei ; Candida parapsilosis ; Candida tropicalis ; agglutinins ; atomic force microscopy ; bacterial infections ; biosensors ; candidiasis ; carbohydrate binding ; cell walls ; concanavalin A ; detection limit ; dielectric spectroscopy ; economic impact ; health services ; hospitals ; morbidity ; mortality ; pathogens ; patients ; therapeutics ; wheat germ ; yeasts
    Sprache Englisch
    Erscheinungsverlauf 2020-1201
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2020.121375
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  8. Artikel ; Online: Nanostructured sensor platform based on organic polymer conjugated to metallic nanoparticle for the impedimetric detection of SARS-CoV-2 at various stages of viral infection.

    Avelino, Karen Y P S / Dos Santos, Giselle S / Frías, Isaac A M / Silva-Junior, Alberto G / Pereira, Michelly C / Pitta, Maira G R / de Araújo, Breno C / Errachid, Abdelhamid / Oliveira, Maria D L / Andrade, César A S

    Journal of pharmaceutical and biomedical analysis

    2021  Band 206, Seite(n) 114392

    Abstract: The projection of new biosensing technologies for genetic identification of SARS-COV-2 is essential in the face of a pandemic scenario. For this reason, the current research aims to develop a label-free flexible biodevice applicable to COVID-19. A ... ...

    Abstract The projection of new biosensing technologies for genetic identification of SARS-COV-2 is essential in the face of a pandemic scenario. For this reason, the current research aims to develop a label-free flexible biodevice applicable to COVID-19. A nanostructured platform made of polypyrrole (PPy) and gold nanoparticles (GNP) was designed for interfacing the electrochemical signal in miniaturized electrodes of tin-doped indium oxide (ITO). Oligonucleotide primer was chemically immobilized on the flexible transducers for the biorecognition of the nucleocapsid protein (N) gene. Methodological protocols based on cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and atomic force microscopy (AFM) were used to characterize the nanotechnological apparatus. The biosensor's electrochemical performance was evaluated using the SARS-CoV-2 genome and biological samples of cDNA from patients infected with retrovirus at various disease stages. It is inferred that the analytical tool was able to distinguish the expression of SARS-CoV-2 in patients diagnosed with COVID-19 in the early, intermediate and late stages. The biosensor exhibited high selectivity by not recognizing the biological target in samples from patients not infected with SARS-CoV-2. The proposed sensor obtained a linear response range estimated from 800 to 4000 copies µL
    Mesh-Begriff(e) Antibodies, Immobilized ; Biosensing Techniques ; COVID-19 ; Electrochemical Techniques ; Electrodes ; Gold ; Humans ; Limit of Detection ; Metal Nanoparticles ; Microelectrodes ; Polymers ; Pyrroles ; SARS-CoV-2
    Chemische Substanzen Antibodies, Immobilized ; Polymers ; Pyrroles ; Gold (7440-57-5)
    Sprache Englisch
    Erscheinungsdatum 2021-09-24
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 604917-5
    ISSN 1873-264X ; 0731-7085
    ISSN (online) 1873-264X
    ISSN 0731-7085
    DOI 10.1016/j.jpba.2021.114392
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