Artikel ; Online: Gastric Cancer Biomarker Candidates Identified by Machine Learning and Integrative Bioinformatics: Toward Personalized Medicine.
Omics : a journal of integrative biology
2023 Band 27, Heft 6, Seite(n) 260–272
Abstract: Gastric cancer (GC) is among the leading causes of cancer-related deaths worldwide. The discovery of robust diagnostic biomarkers for GC remains a challenge. This study sought to identify biomarker candidates for GC by integrating machine learning (ML) ... ...
Abstract | Gastric cancer (GC) is among the leading causes of cancer-related deaths worldwide. The discovery of robust diagnostic biomarkers for GC remains a challenge. This study sought to identify biomarker candidates for GC by integrating machine learning (ML) and bioinformatics approaches. Transcriptome profiles of patients with GC were analyzed to identify differentially expressed genes between the tumor and adjacent normal tissues. Subsequently, we constructed protein-protein interaction networks so as to find the significant hub genes. Along with the bioinformatics integration of ML methods such as support vector machine, the recursive feature elimination was used to select the most informative genes. The analysis unraveled 160 significant genes, with 88 upregulated and 72 downregulated, 10 hub genes, and 12 features from the variable selection method. The integrated analyses found that |
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Mesh-Begriff(e) | Humans ; Biomarkers, Tumor/genetics ; Gene Regulatory Networks ; Precision Medicine ; Stomach Neoplasms/diagnosis ; Stomach Neoplasms/genetics ; Computational Biology/methods ; Machine Learning ; ATPases Associated with Diverse Cellular Activities/genetics ; Cell Cycle Proteins/genetics |
Chemische Substanzen | Biomarkers, Tumor ; TRIP13 protein, human (EC 3.6.4.-) ; ATPases Associated with Diverse Cellular Activities (EC 3.6.4.-) ; Cell Cycle Proteins |
Sprache | Englisch |
Erscheinungsdatum | 2023-05-25 |
Erscheinungsland | United States |
Dokumenttyp | Journal Article |
ZDB-ID | 2030312-9 |
ISSN | 1557-8100 ; 1536-2310 |
ISSN (online) | 1557-8100 |
ISSN | 1536-2310 |
DOI | 10.1089/omi.2023.0015 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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