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  1. Article: Imaging of pleural disease.

    Hassan, Maged / Touman, Abdelfattah A / Grabczak, Elżbieta M / Skaarup, Søren H / Faber, Katarzyna / Blyth, Kevin G / Pochepnia, Svitlana

    Breathe (Sheffield, England)

    2024  Volume 20, Issue 1, Page(s) 230172

    Abstract: The pleural space is a "potential" anatomical space which is formed of two layers: visceral and parietal. It normally contains a trace of fluid (∼10 mL in each hemithorax). Diseases of the pleura can manifest with thickening of the pleural membranes or ... ...

    Abstract The pleural space is a "potential" anatomical space which is formed of two layers: visceral and parietal. It normally contains a trace of fluid (∼10 mL in each hemithorax). Diseases of the pleura can manifest with thickening of the pleural membranes or by abnormal accumulation of air or liquid. Chest radiographs are often the first imaging tests to point to a pleural pathology. With the exception of pneumothorax, and due to the inherent limitations of chest radiographs, ultrasound and/or computed tomography are usually required to further characterise the pleural pathology and guide management. This review summarises the utility of different imaging tools in the management of pleural disease and discusses new and evolving tools in imaging of the pleura.
    Language English
    Publishing date 2024-03-12
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2562899-9
    ISSN 2073-4735 ; 1810-6838
    ISSN (online) 2073-4735
    ISSN 1810-6838
    DOI 10.1183/20734735.0172-2023
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Diseases and Peripheral Pulmonary Lesions - A Stepwise Approach.

    Davidsen, Jesper R / Laursen, Christian B / Skaarup, Søren H / Kronborg-White, Sissel B / Juul, Amanda D

    Journal of visualized experiments : JoVE

    2023  , Issue 197

    Abstract: Transbronchial lung cryobiopsy (TBLC) is an invasive procedure increasingly implemented during the last decade as an alternative to video-assisted thoracic surgery lung biopsy (SLB) for diagnosing interstitial lung diseases (ILDs). The indication for ... ...

    Abstract Transbronchial lung cryobiopsy (TBLC) is an invasive procedure increasingly implemented during the last decade as an alternative to video-assisted thoracic surgery lung biopsy (SLB) for diagnosing interstitial lung diseases (ILDs). The indication for TBLC has primarily been to sub-classify a specific ILD subtype when this cannot be achieved on the basis of a preceding multidisciplinary team discussion. Although SLB is considered the gold standard for establishing a histological diagnosis, TBLC has been gradually suggested as the first-choice histological diagnostic modality in patients with unclassified ILDs due to a comparable diagnostic yield with SLB, but superior to SLB in terms of complications, including mortality. During recent years, radial endobronchial ultrasound (R-EBUS) and electromagnetic navigation bronchoscopy (ENB)-guided TBLC for peripheral pulmonary lesions have also been described as safe procedures, which may improve the diagnostic yield compared to forceps biopsies. Still, the diagnostic properties of TBLC rely on the quality of the procedure's performance. This article aims to describe the stepwise approach to conducting TBLC with a flexible bronchoscope for the different indications mentioned, which might be helpful for novice bronchoscopists performing TBLC.
    MeSH term(s) Humans ; Lung Diseases, Interstitial/diagnosis ; Biopsy ; Bronchoscopy ; Endosonography ; Lung/diagnostic imaging
    Language English
    Publishing date 2023-07-21
    Publishing country United States
    Document type Journal Article ; Video-Audio Media
    ZDB-ID 2259946-0
    ISSN 1940-087X ; 1940-087X
    ISSN (online) 1940-087X
    ISSN 1940-087X
    DOI 10.3791/65753
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: [Malignant pleural effusion].

    Fjællegaard, Katrine / Petersen, Jesper Koefod / Armbruster, Karin / Jensen, Henrin Kirstein / Skaarup, Søren H / Laursen, Christian B / Clementsen, Paul F / Bødtger, Uffe

    Ugeskrift for laeger

    2021  Volume 183, Issue 17

    Abstract: Malignant pleural effusion (MPE) is a common condition, often associated with a high level of symptoms. In this review, several palliative treatments for symptomatic MPE are summarised, including repeated thoracentesis, pleurodesis and insertion of ... ...

    Abstract Malignant pleural effusion (MPE) is a common condition, often associated with a high level of symptoms. In this review, several palliative treatments for symptomatic MPE are summarised, including repeated thoracentesis, pleurodesis and insertion of indwelling pleural catheters. Choice of treatment depends on patient symptoms, life expectancy, pleural fluid production, expected effect of oncological treatment, whether trapped lung is suspected or not, and patient preferences. Treatment should be discussed with a pulmonary specialist with knowledge of pleural diseases.
    MeSH term(s) Catheters, Indwelling ; Drainage ; Humans ; Pleural Effusion, Malignant/therapy ; Pleurodesis ; Thoracentesis
    Language Danish
    Publishing date 2021-04-29
    Publishing country Denmark
    Document type Journal Article ; Review
    ZDB-ID 124102-3
    ISSN 1603-6824 ; 0041-5782
    ISSN (online) 1603-6824
    ISSN 0041-5782
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 302: Show issues Location:
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  4. Article ; Online: Ultrasound Evaluation of Hemidiaphragm Function Following Thoracentesis: A Study on Mechanisms of Dyspnea Related to Pleural Effusion.

    Skaarup, Søren H / Lonni, Sara / Quadri, Federico / Valsecchi, Alberto / Ceruti, Paolo / Marchetti, Giampietro

    Journal of bronchology & interventional pulmonology

    2019  Volume 27, Issue 3, Page(s) 172–178

    Abstract: Background: Dyspnea is the major symptom caused by pleural effusion. The pathophysiological pathways leading to dyspnea are poorly understood. Dysfunction of respiratory mechanics may be a factor. We aimed to study the change in diaphragmatic function ... ...

    Abstract Background: Dyspnea is the major symptom caused by pleural effusion. The pathophysiological pathways leading to dyspnea are poorly understood. Dysfunction of respiratory mechanics may be a factor. We aimed to study the change in diaphragmatic function following thoracentesis.
    Methods: Patients undergoing thoracentesis at a highly specialized pleural center, underwent ultrasound evaluation of hemidiaphragm movement, before and after thoracentesis was performed. The change was compared to the reduction of dyspnea measured at the modified Borg scale.
    Results: Thirty-two patients were included. Dyspnea was reduced from 5.01 [95% confidence interval (CI): 4.12-6.04] to 2.6 (95% CI: 1.87-3.4, P<0.0001). Low hemidiaphragmatic movement before thoracentesis on the side of pleural effusion was improved by 17.4 cm (95% CI: 13.04-21.08), equalizing movement to the side without pleural effusion. On average, 1283 mL (SD: 469) fluid was drained. Multiple linear regression analysis showed that prethoracentesis ultrasound evaluation of hemidiaphragmatic function was correlated with successful thoracentesis.
    Conclusion: Hemidiaphragm function is reduced on the side of pleural effusion, and thoracentesis restores function. Improvement in diaphragm movement is related to a reduction in dyspnea.
    MeSH term(s) Aged ; Aged, 80 and over ; Comorbidity/trends ; Diaphragm/diagnostic imaging ; Diaphragm/physiopathology ; Drainage/methods ; Dyspnea/etiology ; Dyspnea/physiopathology ; Exudates and Transudates ; Female ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Pleural Effusion/complications ; Pleural Effusion/surgery ; Prospective Studies ; Thoracentesis/adverse effects ; Ultrasonography/methods
    Language English
    Publishing date 2019-10-24
    Publishing country United States
    Document type Journal Article ; Observational Study
    ZDB-ID 2478320-1
    ISSN 1948-8270 ; 1944-6586
    ISSN (online) 1948-8270
    ISSN 1944-6586
    DOI 10.1097/LBR.0000000000000627
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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  5. Article: The CRISPR/Cas9 Minipig-A Transgenic Minipig to Produce Specific Mutations in Designated Tissues.

    Berthelsen, Martin Fogtmann / Riedel, Maria / Cai, Huiqiang / Skaarup, Søren H / Alstrup, Aage K O / Dagnæs-Hansen, Frederik / Luo, Yonglun / Jensen, Uffe B / Hager, Henrik / Liu, Ying / Callesen, Henrik / Vendelbo, Mikkel H / Jakobsen, Jannik E / Thomsen, Martin Kristian

    Cancers

    2021  Volume 13, Issue 12

    Abstract: The generation of large transgenic animals is impeded by complex cloning, long maturation and gastrulation times. An introduction of multiple gene alterations increases the complexity. We have cloned a transgenic Cas9 minipig to introduce multiple ... ...

    Abstract The generation of large transgenic animals is impeded by complex cloning, long maturation and gastrulation times. An introduction of multiple gene alterations increases the complexity. We have cloned a transgenic Cas9 minipig to introduce multiple mutations by CRISPR in somatic cells. Transgenic Cas9 pigs were generated by somatic cell nuclear transfer and were backcrossed to Göttingen Minipigs for two generations. Cas9 expression was controlled by FlpO-mediated recombination and was visualized by translation from red to yellow fluorescent protein. In vitro analyses in primary fibroblasts, keratinocytes and lung epithelial cells confirmed the genetic alterations executed by the viral delivery of single guide RNAs (sgRNA) to the target cells. Moreover, multiple gene alterations could be introduced simultaneously in a cell by viral delivery of sgRNAs. Cells with loss of TP53, PTEN and gain-of-function mutation in KRAS
    Language English
    Publishing date 2021-06-16
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers13123024
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  6. Article ; Online: Intralymphatic Immunotherapy: Update and Unmet Needs.

    Senti, Gabriela / Freiburghaus, Andreas U / Larenas-Linnemann, Désirée / Hoffmann, Hans Jürgen / Patterson, Amber M / Klimek, Ludger / Di Bona, Danilo / Pfaar, Oliver / Ahlbeck, Lars / Akdis, Mübeccel / Weinfeld, Dan / Contreras-Verduzco, Francisco A / Pedroza-Melendez, Alvaro / Skaarup, Søren H / Lee, Sang Min / Cardell, Lars-Olaf / Schmid, Johannes M / Westin, Ulla / Dollner, Ralph /
    Kündig, Thomas M

    International archives of allergy and immunology

    2018  Volume 178, Issue 2, Page(s) 141–149

    Abstract: Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as ... ...

    Abstract Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i.e., directly into lymph nodes - intralymphatic immunotherapy (ILIT). The major advantages of ILIT over the current AIT approaches are its short duration and the low allergen doses administered. The whole treatment consists of merely 3 ultrasound-guided injections into inguinal lymph nodes 1 month apart. While the number of patients included in randomised controlled trials is still limited, the clinical results for ILIT are encouraging, but more clinical trials are needed, as well as more preclinical work for optimising formulations.
    MeSH term(s) Allergens/administration & dosage ; Allergens/immunology ; Clinical Trials as Topic ; Desensitization, Immunologic/methods ; Humans ; Hypersensitivity/immunology ; Hypersensitivity/therapy ; Injections, Subcutaneous ; Lymph Nodes/immunology ; Sublingual Immunotherapy ; Treatment Outcome
    Chemical Substances Allergens
    Language English
    Publishing date 2018-11-02
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000493647
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Intralymphatic Immunotherapy: Update and Unmet Needs

    Senti, Gabriela / Freiburghaus, Andreas U. / Larenas-Linnemann, Désirée / Hoffmann, Hans Jürgen / Patterson, Amber M. / Klimek, Ludger / Di Bona, Danilo / Pfaar, Oliver / Ahlbeck, Lars / Akdis, Mübeccel / Weinfeld, Dan / Contreras-Verduzco, Francisco A. / Pedroza-Melendez, Alvaro / Skaarup, Søren H. / Lee, Sang Min / Cardell, Lars-Olaf / Schmid, Johannes M. / Westin, Ulla / Dollner, Ralph /
    Kündig, Thomas M.

    International Archives of Allergy and Immunology

    2018  Volume 178, Issue 2, Page(s) 141–149

    Abstract: Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as ... ...

    Institution Clinical Trials Center, University Hospital Zurich, Zurich, Switzerland
    Hospital Médica Sur, Mexico City, Mexico
    Department of Clinical Medicine, Aarhus University, Aarhus, Denmark
    Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Aarhus, Denmark
    ENT & Allergy Specialists of Northwest Ohio, Findlay, Ohio, USA
    Center for Rhinology and Allergology, Wiesbaden, Germany
    Department of Emergency and Organ Transplantation, Chair and School of Allergology and Clinical Immunology, University of Bari – Aldo Moro, Bari, Italy
    Department of Otorhinolaryngology, Head and Neck Surgery, Universitätsmedizin Mannheim, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany
    Department of Clinical and Experimental Medicine, Division of Neuro and Inflammation Sciences, Linköping University, Linköping, Sweden
    Swiss Institute of Allergy and Asthma Research SIAF, Davos Platz, Switzerland
    Asthma and Allergy Clinic (Adults), Department of Internal Medicine, South Alvsborgs (Central) Hospital, Boras, Sweden
    Allergy Department, National Institute of Pediatrics, Mexico City, Mexico
    Department of Clinical Medicine – Department of Respiratory Diseases and Allergy, Aarhus University, Aarhus, Denmark
    Division of Allergy and Pulmonology, Department of Internal Medicine, Gil Medical Center, Gachon University College of Medicine, Incheon, Republic of Korea
    Division of ENT Diseases, Department of Clinical Sciences, Intervention and Technology, Karolinska Institutet, Stockholm, Sweden
    Division of Ear, Nose and Throat Diseases, Head and Neck Surgery, Department of Clinical Sciences, Lund University, Skane University Hospital, Lund, Sweden
    Region Skane, Skane University Hospital, Malmö, Sweden
    Department Otorhinolaryngology – Head and Neck Surgery, Clinic for Head-Neck and Reconstructive Surgery, Oslo University Hospital (OUS) HF – Rikshospitalet, Oslo, Norway
    Department of Dermatology, University Hospital Zurich, Zurich, Switzerland
    Abstract Allergen-specific immunotherapy (AIT) is the only allergy treatment that confers long-term symptom amelioration for patients suffering from allergy. The most frequently used allergen application route is subcutaneous injection (SCIT), commonly taken as the gold standard, followed by sublingual (SLIT) or oral (OIT) application of allergen preparations. This is an up-to-date review of the clinical evidence for a novel route of allergen application, i.e., directly into lymph nodes – intralymphatic immunotherapy (ILIT). The major advantages of ILIT over the current AIT approaches are its short duration and the low allergen doses administered. The whole treatment consists of merely 3 ultrasound-guided injections into inguinal lymph nodes 1 month apart. While the number of patients included in randomised controlled trials is still limited, the clinical results for ILIT are encouraging, but more clinical trials are needed, as well as more preclinical work for optimising formulations.
    Keywords Allergen-specific immunotherapy ; Allergy ; Clinical trials ; Intralymphatic immunotherapy
    Language English
    Publishing date 2018-11-02
    Publisher S. Karger AG
    Publishing place Basel, Switzerland
    Document type Article
    Note Clinical Allergy – Review Article
    ZDB-ID 1108932-5
    ISSN 1423-0097 ; 1018-2438
    ISSN (online) 1423-0097
    ISSN 1018-2438
    DOI 10.1159/000493647
    Database Karger publisher's database

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