Artikel ; Online: Progresses in overcoming the limitations of in vitro erythropoiesis using human induced pluripotent stem cells.
2024 Band 15, Heft 1, Seite(n) 142
Abstract: Researchers have attempted to generate transfusable oxygen carriers to mitigate RBC supply shortages. In vitro generation of RBCs using stem cells such as hematopoietic stem and progenitor cells (HSPCs), embryonic stem cells (ESCs), and induced ... ...
Abstract | Researchers have attempted to generate transfusable oxygen carriers to mitigate RBC supply shortages. In vitro generation of RBCs using stem cells such as hematopoietic stem and progenitor cells (HSPCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) has shown promise. Specifically, the limited supplies of HSPCs and ethical issues with ESCs make iPSCs the most promising candidate for in vitro RBC generation. However, researchers have encountered some major challenges when using iPSCs to produce transfusable RBC products, such as enucleation and RBC maturation. In addition, it has proven difficult to manufacture these products on a large scale. In this review, we provide a brief overview of erythropoiesis and examine endeavors to recapitulate erythropoiesis in vitro using various cell sources. Furthermore, we explore the current obstacles and potential solutions aimed at enabling the large-scale production of transfusable RBCs in vitro. |
---|---|
Mesh-Begriff(e) | Humans ; Erythropoiesis ; Induced Pluripotent Stem Cells/cytology ; Induced Pluripotent Stem Cells/metabolism ; Erythrocytes/cytology ; Erythrocytes/metabolism ; Cell Differentiation ; Hematopoietic Stem Cells/cytology ; Hematopoietic Stem Cells/metabolism |
Sprache | Englisch |
Erscheinungsdatum | 2024-05-15 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Review |
ZDB-ID | 2548671-8 |
ISSN | 1757-6512 ; 1757-6512 |
ISSN (online) | 1757-6512 |
ISSN | 1757-6512 |
DOI | 10.1186/s13287-024-03754-9 |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
Zusatzmaterialien
Kategorien
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.