Article: Effect of once weekly oral levothyroxine therapy.
Endocrinology, diabetes & metabolism case reports
2021 Volume 2021
Abstract: Summary: Primary hypothyroidism is one of the most common endocrine disorders with widely available treatment. A minority of patients remain with uncontrolled hypothyroidism despite therapy. The objective of this case series was to demonstrate that ... ...
Abstract | Summary: Primary hypothyroidism is one of the most common endocrine disorders with widely available treatment. A minority of patients remain with uncontrolled hypothyroidism despite therapy. The objective of this case series was to demonstrate that medication non-adherence, rather than malabsorption, should be sought as the most common cause of unsuppressed TSH levels in patients receiving treatment for this condition. Non-adherence is often considered as a diagnosis of exclusion. Nonetheless, a diagnosis of malabsorption requires a more extensive workup, including imaging and invasive procedures, which increase healthcare costs and burden to the patient. The findings of this study allow for a cost-effective approach to uncontrolled hypothyroidism. Learning points: Medication non-adherence is a common cause of insuppressible TSH levels. Once weekly levothyroxine is an alternative approach to non-compliant patients. Assessing compliance is more cost-effective and less burdensome than testing for malabsorption. |
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Language | English |
Publishing date | 2021-07-01 |
Publishing country | England |
Document type | Journal Article |
ZDB-ID | 2785530-2 |
ISSN | 2052-0573 |
ISSN | 2052-0573 |
DOI | 10.1530/EDM-21-0045 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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