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  1. Artikel ; Online: When Zebras Collide: A Case of Synchronous Wolff-Parkinson-White Syndrome and Pheochromocytoma.

    Zhu, Kaiwen / Solin, Stacey / Deming, Madeleine S

    The American journal of case reports

    2021  Band 22, Seite(n) e934137

    Abstract: BACKGROUND Pheochromocytoma is a rare catecholamine-secreting tumor arising from chromaffin cells of the adrenal medulla. Wolff-Parkinson-White (WPW) pattern is a rare congenital cardiac conduction disorder in which 1 or more accessory pathways connects ... ...

    Abstract BACKGROUND Pheochromocytoma is a rare catecholamine-secreting tumor arising from chromaffin cells of the adrenal medulla. Wolff-Parkinson-White (WPW) pattern is a rare congenital cardiac conduction disorder in which 1 or more accessory pathways connects the atria and ventricles, bypassing the atrioventricular (AV) node. Patients with this type of accessory pathway who also experience pre-excitation evoked arrhythmias have what is termed WPW syndrome. Here, we present a patient with a WPW pattern who underwent surgical resection of a pheochromocytoma, review considerations relating to the perioperative management, and briefly summarize the hormonal effects of pheochromocytoma in a patient with a WPW accessory pathway. CASE REPORT A man in his early 30's with a history of hypertension developed shortness of breath with palpitations, was noted to have delta waves on electrocardiogram (ECG), and was given a diagnosis of WPW syndrome. Six years later, he developed headache, chest pain, and flank discomfort in addition to his daily palpitations and shortness of breath. Plasma catecholamine levels were measured and found to be elevated, and imaging studies noted the presence of a large right-sided adrenal mass, consistent with a pheochromocytoma. A decision was made to proceed with a laparoscopic right adrenalectomy, which was successful and uneventful. Through the 30-day postoperative period, he reported no further episodes of symptomatic palpitations for the first time in several years. CONCLUSIONS To the best of our knowledge, this is only the fourth case in the literature describing pheochromocytoma with co-existing WPW syndrome. In our case, resection of the pheochromocytoma ameliorated the patient's chronic WPW-related tachyarrhythmia.
    Mesh-Begriff(e) Adrenal Gland Neoplasms/complications ; Adrenal Gland Neoplasms/diagnosis ; Adrenal Gland Neoplasms/surgery ; Animals ; Electrocardiography ; Equidae ; Humans ; Male ; Pheochromocytoma/diagnosis ; Pheochromocytoma/surgery ; Wolff-Parkinson-White Syndrome/diagnosis ; Wolff-Parkinson-White Syndrome/surgery
    Sprache Englisch
    Erscheinungsdatum 2021-12-06
    Erscheinungsland United States
    Dokumenttyp Case Reports ; Journal Article
    ZDB-ID 2517183-5
    ISSN 1941-5923 ; 1941-5923
    ISSN (online) 1941-5923
    ISSN 1941-5923
    DOI 10.12659/AJCR.934137
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Deep phenotyping of post-infectious myalgic encephalomyelitis/chronic fatigue syndrome.

    Walitt, Brian / Singh, Komudi / LaMunion, Samuel R / Hallett, Mark / Jacobson, Steve / Chen, Kong / Enose-Akahata, Yoshimi / Apps, Richard / Barb, Jennifer J / Bedard, Patrick / Brychta, Robert J / Buckley, Ashura Williams / Burbelo, Peter D / Calco, Brice / Cathay, Brianna / Chen, Li / Chigurupati, Snigdha / Chen, Jinguo / Cheung, Foo /
    Chin, Lisa M K / Coleman, Benjamin W / Courville, Amber B / Deming, Madeleine S / Drinkard, Bart / Feng, Li Rebekah / Ferrucci, Luigi / Gabel, Scott A / Gavin, Angelique / Goldstein, David S / Hassanzadeh, Shahin / Horan, Sean C / Horovitz, Silvina G / Johnson, Kory R / Govan, Anita Jones / Knutson, Kristine M / Kreskow, Joy D / Levin, Mark / Lyons, Jonathan J / Madian, Nicholas / Malik, Nasir / Mammen, Andrew L / McCulloch, John A / McGurrin, Patrick M / Milner, Joshua D / Moaddel, Ruin / Mueller, Geoffrey A / Mukherjee, Amrita / Muñoz-Braceras, Sandra / Norato, Gina / Pak, Katherine / Pinal-Fernandez, Iago / Popa, Traian / Reoma, Lauren B / Sack, Michael N / Safavi, Farinaz / Saligan, Leorey N / Sellers, Brian A / Sinclair, Stephen / Smith, Bryan / Snow, Joseph / Solin, Stacey / Stussman, Barbara J / Trinchieri, Giorgio / Turner, Sara A / Vetter, C Stephenie / Vial, Felipe / Vizioli, Carlotta / Williams, Ashley / Yang, Shanna B / Nath, Avindra

    Nature communications

    2024  Band 15, Heft 1, Seite(n) 907

    Abstract: Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous ... ...

    Abstract Post-infectious myalgic encephalomyelitis/chronic fatigue syndrome (PI-ME/CFS) is a disabling disorder, yet the clinical phenotype is poorly defined, the pathophysiology is unknown, and no disease-modifying treatments are available. We used rigorous criteria to recruit PI-ME/CFS participants with matched controls to conduct deep phenotyping. Among the many physical and cognitive complaints, one defining feature of PI-ME/CFS was an alteration of effort preference, rather than physical or central fatigue, due to dysfunction of integrative brain regions potentially associated with central catechol pathway dysregulation, with consequences on autonomic functioning and physical conditioning. Immune profiling suggested chronic antigenic stimulation with increase in naïve and decrease in switched memory B-cells. Alterations in gene expression profiles of peripheral blood mononuclear cells and metabolic pathways were consistent with cellular phenotypic studies and demonstrated differences according to sex. Together these clinical abnormalities and biomarker differences provide unique insight into the underlying pathophysiology of PI-ME/CFS, which may guide future intervention.
    Mesh-Begriff(e) Humans ; Fatigue Syndrome, Chronic/metabolism ; Leukocytes, Mononuclear/metabolism ; Communicable Diseases/metabolism ; Biomarkers/metabolism ; Phenotype
    Chemische Substanzen Biomarkers
    Sprache Englisch
    Erscheinungsdatum 2024-02-21
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-45107-3
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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