Artikel ; Online: Maternal high-fat diet alters the neurobehavioral, biochemical and inflammatory parameters of their adult female rat offspring.
2023 Band 266, Seite(n) 114180
Abstract: Background: Lipid metabolism dysregulations have been associated with depressive and anxious behaviors which can affect pregnant and lactating individuals, with indications that such changes extend to the offspring. Therefore, the aim of this study was ... ...
| Abstract | Background: Lipid metabolism dysregulations have been associated with depressive and anxious behaviors which can affect pregnant and lactating individuals, with indications that such changes extend to the offspring. Therefore, the aim of this study was to evaluate the effect of a maternal high-fat diet on the neurobehavioral, biochemical and inflammatory parameters of their adult female offspring. Methods: Wistar rats ± 90 days old were mated. The dams were allocated to consume a control (CTL) or high-fat (HFD) diet during pregnancy and lactation. After weaning, the female offspring from the CTL (N = 10) and HFD (N = 10) groups received standard chow. The offspring behavioral tests were started at 120 days old. Then, the somatic measures were evaluated followed by euthanasia, histological and biochemical analyses. Results: The HFD group had less ambulation and longer immobility time in the open field test compared to the CTL. The HFD group had lower HDL (48.4%) and a higher adiposity (71.8%) and LDL (62.2%) than the CTL. The CTL had a higher organic acid concentration in the intestine, mainly acetic and butyric acids, however the HFD had a higher citric and acetic acid concentration in the brain and ischemic lesion in the hippocampus with a higher NF-κB concentration. Conclusion: The results demonstrate deleterious effects of a maternal HFD on the neurobehavioral and biochemical parameters of their offspring which may be associated with the role of organic acids and NF-κB in fetal programming. |
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| Mesh-Begriff(e) | Pregnancy ; Humans ; Rats ; Animals ; Female ; Rats, Wistar ; Diet, High-Fat/adverse effects ; Lactation ; NF-kappa B ; Prenatal Exposure Delayed Effects/metabolism ; Maternal Nutritional Physiological Phenomena |
| Chemische Substanzen | NF-kappa B |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-04-08 |
| Erscheinungsland | United States |
| Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 3907-x |
| ISSN | 1873-507X ; 0031-9384 |
| ISSN (online) | 1873-507X |
| ISSN | 0031-9384 |
| DOI | 10.1016/j.physbeh.2023.114180 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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