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  1. Artikel ; Online: Validation of bedside manual versus automated measurements of brain arterial diameters from MR angiography.

    Garzon-Mancera, Nicolas D / Khasiyev, Farid / Del Brutto, Victor J / Spagnolo Allende, Antonio J / Wright, Clinton B / Elkind, Mitchell / Rundek, Tatjana / Del Brutto, Oscar H / Gutierrez, Jose

    Journal of neuroimaging : official journal of the American Society of Neuroimaging

    2024  

    Abstract: Background and purpose: Brain arterial luminal diameters are reliably measured with automated imaging software. Nonautomated imaging software alternatives such as a Picture Archiving Communication System are more common bedside tools used for manual ... ...

    Abstract Background and purpose: Brain arterial luminal diameters are reliably measured with automated imaging software. Nonautomated imaging software alternatives such as a Picture Archiving Communication System are more common bedside tools used for manual measurement. This study is aimed at validating manual measurements against automated methods.
    Methods: We randomly selected 600 participants from the Northern Manhattan Study (NOMAS) and 260 participants from the Atahualpa Project studied with 1.5 Tesla MR angiography. Using the Radiant measuring tool, three independent readers (general practitioner, neurology resident, and vascular neurologist) measured manually the diameter of arterial brain vessels. The same vessels were also measured by LKEB Automated Vessel Analysis (LAVA). We calculated the intraclass correlation coefficient (ICC) of each rater's diameters versus those obtained with LAVA.
    Results: The ICC between diameters obtained by the general practitioner or the neurology resident compared to LAVA was excellent for both internal carotid arteries (ICA) and Basilar Arteries (BA) (ICC > .80 in all comparisons) in NOMAS. In the Atahualpa Project, ICC between diameters obtained by a vascular neurologist and LAVA was good for both ICA and BA (ICC > .60 in all comparisons). The ICCs for the measurements of the remaining arteries were moderate to poor.
    Conclusion: Results suggest that manual measurements of ICA and BA diameters, but not MCA or ACA, are valid and could be used to identify dilated brain arteries at the bedside and for eventual selection of patients with dolichoectasia into clinical trials.
    Sprache Englisch
    Erscheinungsdatum 2024-05-29
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 1071724-9
    ISSN 1552-6569 ; 1051-2284
    ISSN (online) 1552-6569
    ISSN 1051-2284
    DOI 10.1111/jon.13217
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Relationships of Hematocrit With Chronic Covert and Acute Symptomatic Lacunar Ischemic Lesions.

    Roh, David J / Murguia-Fuentes, Ricardo / Gurel, Kursat / Khasiyev, Farid / Rahman, Salwa / Bueno, Pedro Paiva / Kozii, Khrystyna / Spagnolo-Allende, Antonio J / Cottarelli, Azzurra / Simonetto, Marialaura / Ji, Robin / Guo, Jia / Spektor, Vadim / Hod, Eldad A / Burke, Devin J / Konofagou, Elisa / Rundek, Tatjana / Wright, Clinton B / Marshall, Randolph S /
    Elkind, Mitchell S V / Gutierrez, Jose

    Neurology

    2023  Band 102, Heft 2, Seite(n) e207961

    Abstract: Background and objectives: Red blood cell (RBC) concentrations are known to associate with ischemic stroke. It is unclear whether RBC concentrations associate specifically with small vessel disease lacunar infarcts. We investigated the hypothesis that ... ...

    Abstract Background and objectives: Red blood cell (RBC) concentrations are known to associate with ischemic stroke. It is unclear whether RBC concentrations associate specifically with small vessel disease lacunar infarcts. We investigated the hypothesis that RBC concentrations associate with both chronic covert and acute symptomatic brain MRI lacunar infarcts.
    Methods: A cross-sectional observational analysis was performed across 2 cohorts with available hematocrit (as the assessment of RBC concentration exposure) and MRI outcome data. The primary setting was a population-based cohort of stroke-free, older adult (>50 years) participants from the Northern Manhattan Study (NOMAS) enrolled between 2003 and 2009. A second replication sample consisted of patients admitted with acute stroke and enrolled into the Columbia Stroke Registry (CSR) between 2005 and 2020. Associations of hematocrit with (1) chronic, covert lacunar infarcts and (2) symptomatic (i.e., acute) lacunar strokes were separately assessed from the NOMAS and CSR cohorts, respectively, using general additive models after adjusting for relevant covariates.
    Results: Of 1,218 NOMAS participants analyzed, 6% had chronic, covert lacunar infarcts. The association between hematocrit and these covert lacunar infarcts was U-shaped (χ
    Discussion: We identified relationships of hematocrit with MRI lacunar infarcts in both stroke-free and ischemic stroke cohorts, respectively. The relationship between increased hematocrit concentrations with lacunar infarcts was replicated in both cohorts. Further studies are required to clarify the mechanisms behind the relationships of hematocrit with ischemic cerebral small vessel disease.
    Mesh-Begriff(e) Aged ; Humans ; Cross-Sectional Studies ; Hematocrit ; Ischemic Stroke ; Noma ; Stroke ; Stroke, Lacunar/diagnostic imaging ; Middle Aged
    Sprache Englisch
    Erscheinungsdatum 2023-12-19
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Observational Study
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000207961
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 374: Hefte anzeigen

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