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  1. Article ; Online: Étude du système de gestion de l’information (biobank information management system) pour les annotations clinico-biologiques des biobanques.

    Le Queau, Caroline / Ann Phillips, Wendy / Srinivasan, Apoorva

    Medecine sciences : M/S

    2020  Volume 36, Issue 3, Page(s) 285–288

    Title translation Practical use of biobank information management system (BIMS) for clinical-biological annotations in biobanks.
    MeSH term(s) Biological Specimen Banks/economics ; Biological Specimen Banks/organization & administration ; Biological Specimen Banks/standards ; Biomedical Research/economics ; Biomedical Research/methods ; Biomedical Research/organization & administration ; Commerce ; Data Curation/economics ; Data Curation/methods ; Data Curation/standards ; Data Management/economics ; Data Management/methods ; Data Management/organization & administration ; Data Management/standards ; Databases, Factual/standards ; Health Information Management/economics ; Health Information Management/methods ; Health Information Management/organization & administration ; Health Information Management/standards ; Humans ; Information Management/economics ; Information Management/methods ; Information Management/organization & administration ; Information Management/standards ; Organizational Innovation/economics ; Workflow
    Language French
    Publishing date 2020-03-31
    Publishing country France
    Document type News
    ZDB-ID 632733-3
    ISSN 1958-5381 ; 0767-0974
    ISSN (online) 1958-5381
    ISSN 0767-0974
    DOI 10.1051/medsci/2020044
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2872: Show issues Location:
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  2. Article ; Online: Geolocation features differentiate healthy from remitted depressed adults.

    Auerbach, Randy P / Srinivasan, Apoorva / Kirshenbaum, Jaclyn S / Mann, J John / Shankman, Stewart A

    Journal of psychopathology and clinical science

    2022  Volume 131, Issue 4, Page(s) 341–349

    Abstract: Depression recurrence is debilitating, and there is a pressing need to develop clinical tools that detect the reemergence of symptoms with the aim of bridging patients to treatment before recurrences. At baseline, remitted depressed adults ( ...

    Abstract Depression recurrence is debilitating, and there is a pressing need to develop clinical tools that detect the reemergence of symptoms with the aim of bridging patients to treatment before recurrences. At baseline, remitted depressed adults (
    MeSH term(s) Adult ; Depression/epidemiology ; Depression/etiology ; Ecological Momentary Assessment ; Geographic Information Systems ; Health Status ; Humans ; Mobile Applications ; Recurrence ; Secondary Prevention ; Self Report ; Smartphone
    Language English
    Publishing date 2022-02-24
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3121059-4
    ISSN 2769-755X
    ISSN (online) 2769-755X
    DOI 10.1037/abn0000742
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5071: Show issues Location:
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  3. Article ; Online: Suicidal Thoughts and Behaviors Among Adolescent Psychiatric Inpatients.

    Alqueza, Kira L / Pagliaccio, David / Durham, Katherine / Srinivasan, Apoorva / Stewart, Jeremy G / Auerbach, Randy P

    Archives of suicide research : official journal of the International Academy for Suicide Research

    2021  Volume 27, Issue 2, Page(s) 353–366

    Abstract: Background: Given low base rates of suicidal thoughts and behaviors (STBs) in national samples of adolescents, clarifying the sociodemographic and clinical correlates among psychiatric inpatients may afford insights into potential risk factors that ... ...

    Abstract Background: Given low base rates of suicidal thoughts and behaviors (STBs) in national samples of adolescents, clarifying the sociodemographic and clinical correlates among psychiatric inpatients may afford insights into potential risk factors that predict STBs onset.
    Method: Adolescents (
    Results: Age-of-onset for STBs occurred in early adolescence. Most patients reported suicide ideation with nearly half of patients making a plan and one-third a suicide attempt. Although relatively modest, the strongest correlates of lifetime attempts were depressive disorders, physical abuse, and non-suicidal self-injury. Knowing a peer that had attempted suicide also increased the likelihood of a suicide attempt, especially among attempters who transitioned from ideation to planned attempts.
    Conclusion: STBs are highly prevalent among adolescents admitted for acute psychiatric inpatient treatment. The modest effects suggest that correlates, particularly those related to suicide attempts, are widely distributed. As a history of physical abuse and knowing a peer with a suicide attempt history are related to transitioning from ideation to action, these may be critical factors to target in the deployment of future suicide prevention and treatment programs. HIGHLIGHTSOne-third of adolescent inpatients report a lifetime history of suicide attempts.Approximately 65% of adolescent inpatients with a lifetime plan attempt suicide.Knowing peers who attempt suicide may facilitate the transition from ideation to action.
    MeSH term(s) Humans ; Adolescent ; Child ; Young Adult ; Adult ; Inpatients ; Suicidal Ideation ; Suicide, Attempted/psychology ; Suicide Prevention ; Risk Factors
    Language English
    Publishing date 2021-11-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1283671-0
    ISSN 1543-6136 ; 1381-1118
    ISSN (online) 1543-6136
    ISSN 1381-1118
    DOI 10.1080/13811118.2021.1999874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4465: Show issues Location:
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  4. Article ; Online: Diagnosing and staging epithelial ovarian cancer by serum glycoproteomic profiling.

    Dhar, Chirag / Ramachandran, Prasanna / Xu, Gege / Pickering, Chad / Čaval, Tomislav / Wong, Maurice / Rice, Rachel / Zhou, Bo / Srinivasan, Apoorva / Aiyetan, Paul / Chu, Chih-Wei / Moser, Kaitlyn / Herzog, Thomas J / Olawaiye, Alexander Babatunde / Jacob, Francis / Serie, Daniel / Lindpaintner, Klaus / Schwarz, Flavio

    British journal of cancer

    2024  Volume 130, Issue 10, Page(s) 1716–1724

    Abstract: Background: There is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery.: Methods: We applied glycoproteomics to serum of ... ...

    Abstract Background: There is a need for diagnostic tests for screening, triaging and staging of epithelial ovarian cancer (EOC). Glycoproteomics of blood samples has shown promise for biomarker discovery.
    Methods: We applied glycoproteomics to serum of people with EOC or benign pelvic masses and healthy controls. A total of 653 analytes were quantified and assessed in multivariable models, which were tested in an independent cohort. Additionally, we analyzed glycosylation patterns in serum markers and in tissues.
    Results: We identified a biomarker panel that distinguished benign lesions from EOC with sensitivity and specificity of 83.5% and 90.1% in the training set, and of 86.7 and 86.7% in the test set, respectively. ROC analysis demonstrated strong performance across a range of cutoffs. Fucosylated multi-antennary glycopeptide markers were higher in late-stage than in early-stage EOC. A comparable pattern was found in late-stage EOC tissues.
    Conclusions: Blood glycopeptide biomarkers have the potential to distinguish benign from malignant pelvic masses, and early- from late-stage EOC. Glycosylation of circulating and tumor tissue proteins may be related. This study supports the hypothesis that blood glycoproteomic profiling can be used for EOC diagnosis and staging and it warrants further clinical evaluation.
    MeSH term(s) Humans ; Female ; Ovarian Neoplasms/blood ; Ovarian Neoplasms/diagnosis ; Ovarian Neoplasms/pathology ; Carcinoma, Ovarian Epithelial/blood ; Carcinoma, Ovarian Epithelial/diagnosis ; Carcinoma, Ovarian Epithelial/pathology ; Biomarkers, Tumor/blood ; Proteomics/methods ; Middle Aged ; Neoplasm Staging ; Aged ; Glycosylation ; Adult ; Glycopeptides/blood ; Neoplasms, Glandular and Epithelial/blood ; Neoplasms, Glandular and Epithelial/diagnosis ; Neoplasms, Glandular and Epithelial/pathology ; Glycoproteins/blood ; Case-Control Studies ; Sensitivity and Specificity
    Chemical Substances Biomarkers, Tumor ; Glycopeptides ; Glycoproteins
    Language English
    Publishing date 2024-04-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 80075-2
    ISSN 1532-1827 ; 0007-0920
    ISSN (online) 1532-1827
    ISSN 0007-0920
    DOI 10.1038/s41416-024-02644-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intensive Longitudinal Assessment of Adolescents to Predict Suicidal Thoughts and Behaviors.

    Auerbach, Randy P / Lan, Ranqing / Galfalvy, Hanga / Alqueza, Kira L / Cohn, Jeffrey F / Crowley, Ryann N / Durham, Katherine / Joyce, Karla J / Kahn, Lauren E / Kamath, Rahil A / Morency, Louis-Philippe / Porta, Giovanna / Srinivasan, Apoorva / Zelazny, Jamie / Brent, David A / Allen, Nicholas B

    Journal of the American Academy of Child and Adolescent Psychiatry

    2023  Volume 62, Issue 9, Page(s) 1010–1020

    Abstract: Objective: Suicide is a leading cause of death among adolescents. However, there are no clinical tools to detect proximal risk for suicide.: Method: Participants included 13- to 18-year-old adolescents (N = 103) reporting a current depressive, ... ...

    Abstract Objective: Suicide is a leading cause of death among adolescents. However, there are no clinical tools to detect proximal risk for suicide.
    Method: Participants included 13- to 18-year-old adolescents (N = 103) reporting a current depressive, anxiety, and/or substance use disorder who owned a smartphone; 62% reported current suicidal ideation, with 25% indicating a past-year attempt. At baseline, participants were administered clinical interviews to assess lifetime disorders and suicidal thoughts and behaviors (STBs). Self-reports assessing symptoms and suicide risk factors also were obtained. In addition, the Effortless Assessment of Risk States (EARS) app was installed on adolescent smartphones to acquire daily mood and weekly suicidal ideation severity during the 6-month follow-up period. Adolescents completed STB and psychiatric service use interviews at the 1-, 3-, and 6-month follow-up assessments.
    Results: K-means clustering based on aggregates of weekly suicidal ideation scores resulted in a 3-group solution reflecting high-risk (n = 26), medium-risk (n = 47), and low-risk (n = 30) groups. Of the high-risk group, 58% reported suicidal events (ie, suicide attempts, psychiatric hospitalizations, emergency department visits, ideation severity requiring an intervention) during the 6-month follow-up period. For participants in the high-risk and medium-risk groups (n = 73), mood disturbances in the preceding 7 days predicted clinically significant ideation, with a 1-SD decrease in mood doubling participants' likelihood of reporting clinically significant ideation on a given week.
    Conclusion: Intensive longitudinal assessment through use of personal smartphones offers a feasible method to assess variability in adolescents' emotional experiences and suicide risk. Translating these tools into clinical practice may help to reduce the needless loss of life among adolescents.
    MeSH term(s) Humans ; Adolescent ; Suicidal Ideation ; Suicide, Attempted/prevention & control ; Suicide, Attempted/psychology ; Mood Disorders ; Anxiety Disorders ; Risk Factors
    Language English
    Publishing date 2023-05-12
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 392535-3
    ISSN 1527-5418 ; 0890-8567
    ISSN (online) 1527-5418
    ISSN 0890-8567
    DOI 10.1016/j.jaac.2023.03.018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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