LIVIVO - Das Suchportal für Lebenswissenschaften

switch to English language
Erweiterte Suche

Suchergebnis

Treffer 1 - 10 von insgesamt 18

Suchoptionen

  1. Buch ; Dissertation / Habilitation: Einfluss des Serotoninagonisten m-Chlorophenylpiperazin (mCPP) auf Befindlichkeit und Vitalparameter bei gesunden männlichen Probanden

    Stephan, Ralf

    2003  

    Verfasserangabe vorgelegt von Ralf Stephan
    Sprache Deutsch
    Umfang 63 S. : graph. Darst.
    Erscheinungsland Deutschland
    Dokumenttyp Buch ; Dissertation / Habilitation
    Dissertation / Habilitation Bonn, Univ., Diss., 2003
    HBZ-ID HT013890455
    Datenquelle Katalog ZB MED Medizin, Gesundheit

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    SignaturLeihstatusStandort
    2003 D 2741 bestellbar zur Ausleihe Magazin

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  2. Artikel: ChatGPT usage in the Reactome curation process.

    Tiwari, Krishna / Matthews, Lisa / May, Bruce / Shamovsky, Veronica / Orlic-Milacic, Marija / Rothfels, Karen / Ragueneau, Eliot / Gong, Chuqiao / Stephan, Ralf / Li, Nancy / Wu, Guanming / Stein, Lincoln / D'Eustachio, Peter / Hermjakob, Henning

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Appreciating the rapid advancement and ubiquity of generative AI, particularly ChatGPT, a chatbot using large language models like GPT, we endeavour to explore the potential application of ChatGPT in the data collection and annotation stages within the ... ...

    Abstract Appreciating the rapid advancement and ubiquity of generative AI, particularly ChatGPT, a chatbot using large language models like GPT, we endeavour to explore the potential application of ChatGPT in the data collection and annotation stages within the Reactome curation process. This exploration aimed to create an automated or semi-automated framework to mitigate the extensive manual effort traditionally required for gathering and annotating information pertaining to biological pathways, adopting a Reactome "reaction-centric" approach. In this pilot study, we used ChatGPT/GPT4 to address gaps in the pathway annotation and enrichment in parallel with the conventional manual curation process. This approach facilitated a comparative analysis, where we assessed the outputs generated by ChatGPT against manually extracted information. The primary objective of this comparison was to ascertain the efficiency of integrating ChatGPT or other large language models into the Reactome curation workflow and helping plan our annotation pipeline, ultimately improving our protein-to-pathway association in a reliable and automated or semi-automated way. In the process, we identified some promising capabilities and inherent challenges associated with the utilisation of ChatGPT/GPT4 in general and also specifically in the context of Reactome curation processes. We describe approaches and tools for refining the output given by ChatGPT/GPT4 that aid in generating more accurate and detailed output.
    Sprache Englisch
    Erscheinungsdatum 2023-11-08
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.11.08.566195
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  3. Buch: Im Mähdrusch Kosten senken

    Stephan, Ralf

    (Bauernzeitung ; Entscheidungshilfen für Fach- und Führungskräfte ; 2003,2)

    2003  

    Verfasserangabe [Red.: Ralf Stephan]
    Serientitel Bauernzeitung
    Entscheidungshilfen für Fach- und Führungskräfte ; 2003,2
    Sprache Deutsch
    Umfang 43 S, Ill., graph. Darst, 30 cm
    Verlag Dt. Bauernverl
    Erscheinungsort Berlin
    Dokumenttyp Buch
    Datenquelle Johann Heinrich von Thünen-Institut, Bundesforschunginstitut für Ländliche Räume, Wald und Fischerei

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  4. Artikel ; Online: Pathway-based, reaction-specific annotation of disease variants for elucidation of molecular phenotypes.

    Orlic-Milacic, Marija / Rothfels, Karen / Matthews, Lisa / Wright, Adam / Jassal, Bijay / Shamovsky, Veronica / Trinh, Quang / Gillespie, Marc E / Sevilla, Cristoffer / Tiwari, Krishna / Ragueneau, Eliot / Gong, Chuqiao / Stephan, Ralf / May, Bruce / Haw, Robin / Weiser, Joel / Beavers, Deidre / Conley, Patrick / Hermjakob, Henning /
    Stein, Lincoln D / D'Eustachio, Peter / Wu, Guanming

    Database : the journal of biological databases and curation

    2024  Band 2024

    Abstract: Germline and somatic mutations can give rise to proteins with altered activity, including both gain and loss-of-function. The effects of these variants can be captured in disease-specific reactions and pathways that highlight the resulting changes to ... ...

    Abstract Germline and somatic mutations can give rise to proteins with altered activity, including both gain and loss-of-function. The effects of these variants can be captured in disease-specific reactions and pathways that highlight the resulting changes to normal biology. A disease reaction is defined as an aberrant reaction in which a variant protein participates. A disease pathway is defined as a pathway that contains a disease reaction. Annotation of disease variants as participants of disease reactions and disease pathways can provide a standardized overview of molecular phenotypes of pathogenic variants that is amenable to computational mining and mathematical modeling. Reactome (https://reactome.org/), an open source, manually curated, peer-reviewed database of human biological pathways, in addition to providing annotations for >11 000 unique human proteins in the context of ∼15 000 wild-type reactions within more than 2000 wild-type pathways, also provides annotations for >4000 disease variants of close to 400 genes as participants of ∼800 disease reactions in the context of ∼400 disease pathways. Functional annotation of disease variants proceeds from normal gene functions, described in wild-type reactions and pathways, through disease variants whose divergence from normal molecular behaviors has been experimentally verified, to extrapolation from molecular phenotypes of characterized variants to variants of unknown significance using criteria of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Reactome's data model enables mapping of disease variant datasets to specific disease reactions within disease pathways, providing a platform to infer pathway output impacts of numerous human disease variants and model organism orthologs, complementing computational predictions of variant pathogenicity. Database URL: https://reactome.org/.
    Mesh-Begriff(e) Humans ; Phenotype ; Molecular Sequence Annotation ; Databases, Genetic ; Disease/genetics
    Sprache Englisch
    Erscheinungsdatum 2024-04-29
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2496706-3
    ISSN 1758-0463 ; 1758-0463
    ISSN (online) 1758-0463
    ISSN 1758-0463
    DOI 10.1093/database/baae031
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  5. Artikel ; Online: The LOTUS initiative for open knowledge management in natural products research.

    Rutz, Adriano / Sorokina, Maria / Galgonek, Jakub / Mietchen, Daniel / Willighagen, Egon / Gaudry, Arnaud / Graham, James G / Stephan, Ralf / Page, Roderic / Vondrášek, Jiří / Steinbeck, Christoph / Pauli, Guido F / Wolfender, Jean-Luc / Bisson, Jonathan / Allard, Pierre-Marie

    eLife

    2022  Band 11

    Abstract: Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis and interpretation of data in natural products research. Currently, reliance on a disparate set of non-standardized, insular, and ... ...

    Abstract Contemporary bioinformatic and chemoinformatic capabilities hold promise to reshape knowledge management, analysis and interpretation of data in natural products research. Currently, reliance on a disparate set of non-standardized, insular, and specialized databases presents a series of challenges for data access, both within the discipline and for integration and interoperability between related fields. The fundamental elements of exchange are referenced structure-organism pairs that establish relationships between distinct molecular structures and the living organisms from which they were identified. Consolidating and sharing such information via an open platform has strong transformative potential for natural products research and beyond. This is the ultimate goal of the newly established LOTUS initiative, which has now completed the first steps toward the harmonization, curation, validation and open dissemination of 750,000+ referenced structure-organism pairs. LOTUS data is hosted on Wikidata and regularly mirrored on https://lotus.naturalproducts.net. Data sharing within the Wikidata framework broadens data access and interoperability, opening new possibilities for community curation and evolving publication models. Furthermore, embedding LOTUS data into the vast Wikidata knowledge graph will facilitate new biological and chemical insights. The LOTUS initiative represents an important advancement in the design and deployment of a comprehensive and collaborative natural products knowledge base.
    Mesh-Begriff(e) Biological Products ; Computational Biology ; Databases, Factual ; Knowledge ; Knowledge Management
    Chemische Substanzen Biological Products
    Sprache Englisch
    Erscheinungsdatum 2022-05-26
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.70780
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  6. Artikel ; Online: Using the Reactome Database.

    Rothfels, Karen / Milacic, Marija / Matthews, Lisa / Haw, Robin / Sevilla, Cristoffer / Gillespie, Marc / Stephan, Ralf / Gong, Chuqiao / Ragueneau, Eliot / May, Bruce / Shamovsky, Veronica / Wright, Adam / Weiser, Joel / Beavers, Deidre / Conley, Patrick / Tiwari, Krishna / Jassal, Bijay / Griss, Johannes / Senff-Ribeiro, Andrea /
    Brunson, Timothy / Petryszak, Robert / Hermjakob, Henning / D'Eustachio, Peter / Wu, Guanming / Stein, Lincoln

    Current protocols

    2023  Band 3, Heft 4, Seite(n) e722

    Abstract: Pathway databases provide descriptions of the roles of proteins, nucleic acids, lipids, carbohydrates, and other molecular entities within their biological cellular contexts. Pathway-centric views of these roles may allow for the discovery of unexpected ... ...

    Abstract Pathway databases provide descriptions of the roles of proteins, nucleic acids, lipids, carbohydrates, and other molecular entities within their biological cellular contexts. Pathway-centric views of these roles may allow for the discovery of unexpected functional relationships in data such as gene expression profiles and somatic mutation catalogues from tumor cells. For this reason, there is a high demand for high-quality pathway databases and their associated tools. The Reactome project (a collaboration between the Ontario Institute for Cancer Research, New York University Langone Health, the European Bioinformatics Institute, and Oregon Health & Science University) is one such pathway database. Reactome collects detailed information on biological pathways and processes in humans from the primary literature. Reactome content is manually curated, expert-authored, and peer-reviewed and spans the gamut from simple intermediate metabolism to signaling pathways and complex cellular events. This information is supplemented with likely orthologous molecular reactions in mouse, rat, zebrafish, worm, and other model organisms. © 2023 The Authors. Current Protocols published by Wiley Periodicals LLC. Basic Protocol 1: Browsing a Reactome pathway Basic Protocol 2: Exploring Reactome annotations of disease and drugs Basic Protocol 3: Finding the pathways involving a gene or protein Alternate Protocol 1: Finding the pathways involving a gene or protein using UniProtKB (SwissProt), Ensembl, or Entrez gene identifier Alternate Protocol 2: Using advanced search Basic Protocol 4: Using the Reactome pathway analysis tool to identify statistically overrepresented pathways Basic Protocol 5: Using the Reactome pathway analysis tool to overlay expression data onto Reactome pathway diagrams Basic Protocol 6: Comparing inferred model organism and human pathways using the Species Comparison tool Basic Protocol 7: Comparing tissue-specific expression using the Tissue Distribution tool.
    Mesh-Begriff(e) Humans ; Animals ; Mice ; Rats ; Metabolic Networks and Pathways ; Zebrafish/metabolism ; Databases, Protein ; Proteins/metabolism ; Signal Transduction
    Chemische Substanzen Proteins
    Sprache Englisch
    Erscheinungsdatum 2023-04-13
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ISSN 2691-1299
    ISSN (online) 2691-1299
    DOI 10.1002/cpz1.722
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  7. Artikel ; Online: The Reactome Pathway Knowledgebase 2024.

    Milacic, Marija / Beavers, Deidre / Conley, Patrick / Gong, Chuqiao / Gillespie, Marc / Griss, Johannes / Haw, Robin / Jassal, Bijay / Matthews, Lisa / May, Bruce / Petryszak, Robert / Ragueneau, Eliot / Rothfels, Karen / Sevilla, Cristoffer / Shamovsky, Veronica / Stephan, Ralf / Tiwari, Krishna / Varusai, Thawfeek / Weiser, Joel /
    Wright, Adam / Wu, Guanming / Stein, Lincoln / Hermjakob, Henning / D'Eustachio, Peter

    Nucleic acids research

    2023  Band 52, Heft D1, Seite(n) D672–D678

    Abstract: The Reactome Knowledgebase (https://reactome.org), an Elixir and GCBR core biological data resource, provides manually curated molecular details of a broad range of normal and disease-related biological processes. Processes are annotated as an ordered ... ...

    Abstract The Reactome Knowledgebase (https://reactome.org), an Elixir and GCBR core biological data resource, provides manually curated molecular details of a broad range of normal and disease-related biological processes. Processes are annotated as an ordered network of molecular transformations in a single consistent data model. Reactome thus functions both as a digital archive of manually curated human biological processes and as a tool for discovering functional relationships in data such as gene expression profiles or somatic mutation catalogs from tumor cells. Here we review progress towards annotation of the entire human proteome, targeted annotation of disease-causing genetic variants of proteins and of small-molecule drugs in a pathway context, and towards supporting explicit annotation of cell- and tissue-specific pathways. Finally, we briefly discuss issues involved in making Reactome more fully interoperable with other related resources such as the Gene Ontology and maintaining the resulting community resource network.
    Mesh-Begriff(e) Humans ; Knowledge Bases ; Metabolic Networks and Pathways/genetics ; Proteome/genetics ; Signal Transduction
    Chemische Substanzen Proteome
    Sprache Englisch
    Erscheinungsdatum 2023-11-08
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 186809-3
    ISSN 1362-4962 ; 1362-4954 ; 0301-5610 ; 0305-1048
    ISSN (online) 1362-4962 ; 1362-4954
    ISSN 0301-5610 ; 0305-1048
    DOI 10.1093/nar/gkad1025
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Zs.A 1067: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  8. Artikel: Pathway-based, reaction-specific annotation of disease variants for elucidation of molecular phenotypes.

    Orlic-Milacic, Marija / Rothfels, Karen / Matthews, Lisa / Wright, Adam / Jassal, Bijay / Shamovsky, Veronica / Trinh, Quang / Gillespie, Marc / Sevilla, Cristoffer / Tiwari, Krishna / Ragueneau, Eliot / Gong, Chuqiao / Stephan, Ralf / May, Bruce / Haw, Robin / Weiser, Joel / Beavers, Deidre / Conley, Patrick / Hermjakob, Henning /
    Stein, Lincoln D / D'Eustachio, Peter / Wu, Guanming

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Disease variant annotation in the context of biological reactions and pathways can provide a standardized overview of molecular phenotypes of pathogenic mutations that is amenable to computational mining and mathematical modeling. Reactome, an open ... ...

    Abstract Disease variant annotation in the context of biological reactions and pathways can provide a standardized overview of molecular phenotypes of pathogenic mutations that is amenable to computational mining and mathematical modeling. Reactome, an open source, manually curated, peer-reviewed database of human biological pathways, provides annotations for over 4000 disease variants of close to 400 genes in the context of ∼800 disease reactions constituting ∼400 disease pathways. Functional annotation of disease variants proceeds from normal gene functions, through disease variants whose divergence from normal molecular behaviors has been experimentally verified, to extrapolation from molecular phenotypes of characterized variants to variants of unknown significance using criteria of the American College of Medical Genetics and Genomics (ACMG). Reactome's pathway-based, reaction-specific disease variant dataset and data model provide a platform to infer pathway output impacts of numerous human disease variants and model organism orthologs, complementing computational predictions of variant pathogenicity.
    Sprache Englisch
    Erscheinungsdatum 2023-10-21
    Erscheinungsland United States
    Dokumenttyp Preprint
    DOI 10.1101/2023.10.18.562964
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

    Zusatzmaterialien

    Kategorien

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

  9. Artikel ; Konferenzbeitrag: The LOTUS initiative for knowledge sharing in Natural Products research

    Rutz, Adriano / Sorokina, Maria / Galgonek, Jakub / Mietchen, Daniel / Willighagen, Egon / Gaudry, Arnaud / Graham, James G. / Stephan, Ralf / Page, Roderic / Vondrášek, Jiří / Steinbeck, Christoph / Pauli, Guido F. / Wolfender, Jean-Luc / Bisson, Jonathan / Allard, Pierre-Marie

    Planta Medica

    2021  Band 87, Heft 15

    Veranstaltung/Kongress GA - 69th Annual Meeting 2021, Virtual conference, Bonn, Germany, 2021-09-05
    Sprache Englisch
    Erscheinungsdatum 2021-12-01
    Verlag Georg Thieme Verlag
    Erscheinungsort Stuttgart ; New York
    Dokumenttyp Artikel ; Konferenzbeitrag
    ZDB-ID 123545-x
    ISSN 1439-0221 ; 0032-0943
    ISSN (online) 1439-0221
    ISSN 0032-0943
    DOI 10.1055/s-0041-1736777
    Datenquelle Thieme Verlag

    Zusatzmaterialien

    Kategorien

    Verfügbar in ZB MED Köln/Königswinter

    Uf I Zs.157: Hefte anzeigen Standort:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

  10. Artikel: Das Zusammenwachsen der Rentenversicherungen in West und Ost: eine Zwischenbilanz im zehnten Jahr der Deutschen Einheit

    Stephan, Ralf-Peter

    Die Angestellten-Versicherung : Zeitschrift der Bundesversicherungsanstalt für Angestellte ; amtliches Veröffentlichungsblatt Vol. 46, No. 12 , p. 546-556

    1999  Band 46, Heft 12, Seite(n) 546–556

    Verfasserangabe von Ralf-Peter Stephan
    Schlagwörter Gesetzliche Rentenversicherung ; Alte Bundesländer ; Neue Bundesländer ; Deutschland
    Sprache Deutsch
    Verlag Bundesversicherungsanstalt
    Erscheinungsort Berlin
    Dokumenttyp Artikel
    ZDB-ID 279-3
    Datenquelle ECONomics Information System

    Zusatzmaterialien

    Kategorien

    Über subito bestellen

    Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.

    Fernleihe an ZB MED

    Sie können sich den gewünschten Titel als lokale Nutzerin oder lokaler Nutzer von ZB MED direkt an den Standort Köln schicken lassen.

Zum Seitenanfang