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  1. Artikel: RETRACTED: Sturtz, M.; House, C. Metal Catalysis Acting on Nitriles in Early Earth Hydrothermal Systems.

    Sturtz, Miranda / House, Christopher

    Life (Basel, Switzerland)

    2024  Band 14, Heft 4

    Abstract: ... ...

    Abstract The
    Sprache Englisch
    Erscheinungsdatum 2024-03-26
    Erscheinungsland Switzerland
    Dokumenttyp Retraction of Publication
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life14040439
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Metal Catalysis Acting on Nitriles in Early Earth Hydrothermal Systems.

    Sturtz, Miranda / House, Christopher

    Publikation ZURÜCKGEZOGEN

    Life (Basel, Switzerland)

    2023  Band 13, Heft 7

    Abstract: Hydrothermal systems are areas in which heated fluids and organic molecules rush through basaltic material rich in metals and minerals. By studying malononitrile and acetonitrile, we examine the effects of metal and mineral nanoparticles on nitrile ... ...

    Abstract Hydrothermal systems are areas in which heated fluids and organic molecules rush through basaltic material rich in metals and minerals. By studying malononitrile and acetonitrile, we examine the effects of metal and mineral nanoparticles on nitrile compounds in anoxic, hydrothermal conditions representing a prebiotic environment of early Earth. Polymerization, reduction, cyclization, and a phenomenon colloquially known as 'chemical gardening' (structure building via reprecipitation of metal compounds or complexing with organics) are all potential outcomes with the addition of metals and minerals. Reduction occurs with the addition of rhodium (Rh) or iron (II) sulfide (FeS), with positive identification of ethanol and ethylamine forming from acetonitrile reduction. We find that polymerization and insoluble product formation were associated with oxide minerals, metallic nickel (Ni), and metallic cobalt (Co) acting as catalysts. Oxide minerals strongly promoted polymerization into insoluble, tar-like products of nitriles. FeS, iron-nickel alloy (FeNi), and rhodium are unique cases that appear to act as reagents by actively participating in chemical gardening without returning to their initial state. Further, FeS tentatively had a phase change into the mineral parabutlerite. This research aims to identify metals and metal minerals that could best serve nitrile catalysis and reactions on early Earth.
    Sprache Englisch
    Erscheinungsdatum 2023-07-07
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Retracted Publication
    ZDB-ID 2662250-6
    ISSN 2075-1729
    ISSN 2075-1729
    DOI 10.3390/life13071524
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Avian influenza A viruses exhibit plasticity in sialylglycoconjugate receptor usage in human lung cells.

    Liang, Chieh-Yu / Huang, Iris / Han, Julianna / Sownthirarajan, Boopathi / Kulhankova, Katarina / Murray, Nathan B / Taherzadeh, Mehrnoush / Archer-Hartmann, Stephanie / Pepi, Lauren / Manivasagam, Senthamizharasi / Plung, Jesse / Sturtz, Miranda / Yu, Yolanda / Vogel, Olivia A / Kandasamy, Matheswaran / Gourronc, Francoise A / Klingelhutz, Aloysius J / Choudhury, Biswa / Rong, Lijun /
    Perez, Jasmine T / Azadi, Parastoo / McCray, Paul B / Neelamegham, Sriram / Manicassamy, Balaji

    Journal of virology

    2023  Band 97, Heft 11, Seite(n) e0090623

    Abstract: Importance: It is well known that influenza A viruses (IAV) initiate host cell infection by binding to sialic acid, a sugar molecule present at the ends of various sugar chains called glycoconjugates. These sugar chains can vary in chain length, ... ...

    Abstract Importance: It is well known that influenza A viruses (IAV) initiate host cell infection by binding to sialic acid, a sugar molecule present at the ends of various sugar chains called glycoconjugates. These sugar chains can vary in chain length, structure, and composition. However, it remains unknown if IAV strains preferentially bind to sialic acid on specific glycoconjugate type(s) for host cell infection. Here, we utilized CRISPR gene editing to abolish sialic acid on different glycoconjugate types in human lung cells, and evaluated human versus avian IAV infections. Our studies show that both human and avian IAV strains can infect human lung cells by utilizing any of the three major sialic acid-containing glycoconjugate types, specifically N-glycans, O-glycans, and glycolipids. Interestingly, simultaneous elimination of sialic acid on all three major glycoconjugate types in human lung cells dramatically decreased human IAV infection, yet had little effect on avian IAV infection. These studies show that avian IAV strains effectively utilize other less prevalent glycoconjugates for infection, whereas human IAV strains rely on a limited repertoire of glycoconjugate types. The remarkable ability of avian IAV strains to utilize diverse glycoconjugate types may allow for easy transmission into new host species.
    Mesh-Begriff(e) Animals ; Humans ; Carrier Proteins/metabolism ; Glycoconjugates/metabolism ; Influenza A virus/metabolism ; Influenza, Human ; Lung/virology ; N-Acetylneuraminic Acid/metabolism ; Polysaccharides/metabolism ; Sugars/metabolism ; Influenza in Birds/metabolism ; Receptors, Cell Surface/metabolism ; Receptors, Virus/metabolism
    Chemische Substanzen Carrier Proteins ; Glycoconjugates ; N-Acetylneuraminic Acid (GZP2782OP0) ; Polysaccharides ; Sugars ; Receptors, Cell Surface ; Receptors, Virus
    Sprache Englisch
    Erscheinungsdatum 2023-10-16
    Erscheinungsland United States
    Dokumenttyp Journal Article
    ZDB-ID 80174-4
    ISSN 1098-5514 ; 0022-538X
    ISSN (online) 1098-5514
    ISSN 0022-538X
    DOI 10.1128/jvi.00906-23
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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