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  1. Artikel ; Online: Extracts of

    Ma, Juncheng / Wei, Juanru / Chen, Gang / Yan, Xiaowei / Sun, Hechun / Li, Ning

    Pharmaceutical biology

    2023  Band 61, Heft 1, Seite(n) 1446–1453

    Abstract: Context: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading rapidly. Relevant research based on the antiviral effects of : Objective: To investigate the antiviral and anti-inflammatory effects of extracts of : ... ...

    Abstract Context: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is still spreading rapidly. Relevant research based on the antiviral effects of
    Objective: To investigate the antiviral and anti-inflammatory effects of extracts of
    Materials and methods: To investigate the anti-entry and replication effect of the ethanol extract of
    Results: The ethanol extract of
    Conclusion: T. chinense
    Mesh-Begriff(e) Chlorocebus aethiops ; Animals ; SARS-CoV-2 ; COVID-19 ; Interleukin-6 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Vero Cells ; Inflammation/drug therapy ; Antiviral Agents/pharmacology ; Ethanol
    Chemische Substanzen Interleukin-6 ; Lipopolysaccharides ; Tumor Necrosis Factor-alpha ; Antiviral Agents ; Ethanol (3K9958V90M)
    Sprache Englisch
    Erscheinungsdatum 2023-09-11
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 1440131-9
    ISSN 1744-5116 ; 1388-0209
    ISSN (online) 1744-5116
    ISSN 1388-0209
    DOI 10.1080/13880209.2023.2253841
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: [Evaluation of the influence of humidity and temperature on the drug stability by initial average rate experiment].

    He, Ning / Sun, Hechun / Dai, Miaomiao

    Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences

    2014  Band 39, Heft 5, Seite(n) 501–510

    Abstract: Objective: To evaluate the influence of temperature and humidity on the drug stability by initial average rate experiment, and to obtained the kinetic parameters.: Methods: The effect of concentration error, drug degradation extent, humidity and ... ...

    Abstract Objective: To evaluate the influence of temperature and humidity on the drug stability by initial average rate experiment, and to obtained the kinetic parameters.
    Methods: The effect of concentration error, drug degradation extent, humidity and temperature numbers, humidity and temperature range, and average humidity and temperature on the accuracy and precision of kinetic parameters in the initial average rate experiment was explored. The stability of vitamin C, as a solid state model, was investigated by an initial average rate experiment.
    Results: Under the same experimental conditions, the kinetic parameters obtained from this proposed method were comparable to those from classical isothermal experiment at constant humidity. The estimates were more accurate and precise by controlling the extent of drug degradation, changing humidity and temperature range, or by setting the average temperature closer to room temperature.
    Conclusion: Compared with isothermal experiments at constant humidity, our proposed method saves time, labor, and materials.
    Mesh-Begriff(e) Ascorbic Acid/chemistry ; Drug Stability ; Humidity ; Kinetics ; Temperature
    Chemische Substanzen Ascorbic Acid (PQ6CK8PD0R)
    Sprache Chinesisch
    Erscheinungsdatum 2014-05
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article
    ZDB-ID 2168533-2
    ISSN 1672-7347
    ISSN 1672-7347
    DOI 10.3969/j.issn.1672-7347.2014.05.011
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel: [Synthesis and characterization of PEG-b-(PG-g-PEI) for gene delivery].

    He, Ning / Sun, Hechun / Xu, Huanxi / Dong, Xiaoman / Shao, Zhangzhang

    Nan fang yi ke da xue xue bao = Journal of Southern Medical University

    2013  Band 33, Heft 11, Seite(n) 1643–1647

    Abstract: Objective: To synthesize a biodegradable non-viral gene carrier with a high transfection efficiency and a low cytotoxicity.: Methods: Poly(ethylene glycol)-block-(poly(L-glutamic acid)-graft-polyethylenimine) was prepared via ammonolysis of poly( ... ...

    Abstract Objective: To synthesize a biodegradable non-viral gene carrier with a high transfection efficiency and a low cytotoxicity.
    Methods: Poly(ethylene glycol)-block-(poly(L-glutamic acid)-graft-polyethylenimine) was prepared via ammonolysis of poly(ethylene glycol)-block-poly (γ-benzyl L-glutamate) with the low-molecular-mass polyethylenimine (600 Da). The synthesized copolymer was characterized by 1H nuclear magnetic resonance spectroscopy and gel permeation chromatography. The polyplex micelle from PEG-b-(PG-g-PEI) and plasmid DNA (pDNA) was studied using dynamic light scattering, zeta-potential measurements, and gel retardation assay. The in vitro cytotoxicity and transfection efficiency of PEG-b-(PG-g-PEI) were tested by MTT assay and luciferase assay in HEK 293T cells using PEI (25 kDa) as the control.
    Results: PEG-b-(PG-g-PEI) could efficiently condense DNA into nanosized particles with positive surface charges when the N/P ratio of polymer and DNA was above 5:1. The zeta potential of the polyplexes was about 25 mV, and the particle size was 120 nm at a N/P ratio of 10. The cell toxicity and gene transfection evaluations showed a lower cytotoxicity and a higher gene transfection efficiency of the copolymer than PEI 25000 in HEK 293T cells.
    Conclusions: The polymer can be used as a potential non-viral gene carrier for gene therapy.
    Mesh-Begriff(e) Cell Survival ; Gene Transfer Techniques ; Genetic Vectors ; Glutamic Acid/chemistry ; HEK293 Cells ; Humans ; Particle Size ; Plasmids ; Polyethylene Glycols/chemical synthesis ; Polyethylene Glycols/chemistry ; Polyethyleneimine/analogs & derivatives ; Polyethyleneimine/chemical synthesis ; Polyethyleneimine/chemistry ; Polyglutamic Acid/analogs & derivatives ; Polyglutamic Acid/chemical synthesis ; Polyglutamic Acid/chemistry ; Polymers ; Transfection
    Chemische Substanzen PEG-b-(PG-g-PEI) ; Polymers ; poly(ethylene glycol)-co-poly(ethyleneimine) ; Polyglutamic Acid (25513-46-6) ; Polyethylene Glycols (30IQX730WE) ; Glutamic Acid (3KX376GY7L) ; Polyethyleneimine (9002-98-6)
    Sprache Chinesisch
    Erscheinungsdatum 2013-11
    Erscheinungsland China
    Dokumenttyp English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2250951-3
    ISSN 1673-4254
    ISSN 1673-4254
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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