Artikel ; Online: Antiosteoporosis effect of bryodulcosigenin on ovariectomy-induced osteoporosis in experimental rats.
2024 Band 39, Seite(n) e391024
Abstract: Purpose: Osteoporosis is a bone disease which commonly occurred in postmenopausal women. Almost 10 percent of world population and approximately 30% of women (postmenopausal) suffer from this disease. Alternative medicine has great success in the ... ...
| Abstract | Purpose: Osteoporosis is a bone disease which commonly occurred in postmenopausal women. Almost 10 percent of world population and approximately 30% of women (postmenopausal) suffer from this disease. Alternative medicine has great success in the treatment of osteoporosis disease. Bryodulcosigenin, a potent phytoconstituent, already displayed the anti-inflammatory and antioxidant effect. In this study, we made effort to analyze the antiosteoporosis effect of bryodulcosigenin against ovariectomy (OVX) induced osteoporosis in rats. Methods: Swiss albino Wistar rats were grouped into fIve groups and given an oral dose of bryodulcosigenin (10, 20 and 30 mg/kg) for eight weeks. Body weight, uterus, bone mineral density, cytokines, hormones parameters, transforming growth factor (TGF)-β, insulin-like growth factor (IGF), osteoprotegerin (OPG), receptor activator of nuclear factor kappa-Β ligand (RANKL), and its ratio were estimated. Results: Bryodulcosigenin significantly (p < 0.001) suppressed the body weight and enhanced the uterine weight and significantly (p < 0.001) increased the bone mineral density in whole femur, caput femoris, distal femur and proximal femur. Bryodulcosigenin significantly (P < 0.001) altered the level of biochemical parameters at dose dependent manner, significantly (P < 0.001) improved the level of estrogen and suppressed the level of follicle stimulating hormone and luteinizing hormone. Bryodulcosigenin significantly (P < 0.001) improved the level of OPG and suppressed the level of RANKL. Conclusions: Bryodulcosigenin reduced the cytokines level and suppressed the TGF-β and IGF. We concluded that bryodulcosigenin is an antiosteoporosis medication based on the findings. |
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| Mesh-Begriff(e) | Animals ; Female ; Rats, Wistar ; Ovariectomy ; Bone Density/drug effects ; Osteoporosis/drug therapy ; Osteoporosis/prevention & control ; Osteoporosis/etiology ; Rats ; Body Weight/drug effects ; Disease Models, Animal ; Uterus/drug effects ; Cytokines/blood ; Cytokines/drug effects ; Femur/drug effects ; Treatment Outcome |
| Chemische Substanzen | Cytokines |
| Sprache | Englisch |
| Erscheinungsdatum | 2024-04-22 |
| Erscheinungsland | Brazil |
| Dokumenttyp | Journal Article |
| ZDB-ID | 2012156-8 |
| ISSN | 1678-2674 ; 1678-2674 |
| ISSN (online) | 1678-2674 |
| ISSN | 1678-2674 |
| DOI | 10.1590/acb391024 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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