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  1. Article ; Online: Serum from Jiao-Tai-Wan treated rats increases glucose consumption by 3T3-L1 adipocytes through AMPK pathway signaling.

    Yuan, Lin / Tang, Peng / Li, Hui-Jiao / Hu, Na / Zhong, Xiao-Yu / Lin, Min / Sun, Yin-Qiang / Lu, Min / Lu, Xiong

    Bioscience reports

    2019  Volume 39, Issue 4

    Abstract: Type 2 diabetes (T2DM) is characterized by hyperglycemia resulting from insulin resistance. Jiao-Tai-Wan (JTW), a traditional Chinese medicine consisting of a 10:1 formulation ... ...

    Abstract Type 2 diabetes (T2DM) is characterized by hyperglycemia resulting from insulin resistance. Jiao-Tai-Wan (JTW), a traditional Chinese medicine consisting of a 10:1 formulation of
    MeSH term(s) 3T3 Cells ; AMP-Activated Protein Kinases/antagonists & inhibitors ; AMP-Activated Protein Kinases/metabolism ; Adipocytes/metabolism ; Animals ; Cell Line ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/pathology ; Disease Models, Animal ; Drugs, Chinese Herbal/pharmacology ; Glucose/metabolism ; Glucose Transporter Type 4/metabolism ; Hyperglycemia/drug therapy ; Hyperglycemia/pathology ; Hypoglycemic Agents/pharmacology ; Insulin Resistance/physiology ; Male ; Mice ; Rats ; Serum/chemistry
    Chemical Substances Drugs, Chinese Herbal ; Glucose Transporter Type 4 ; Hypoglycemic Agents ; Slc2a4 protein, mouse ; jiao tai wan ; AMP-Activated Protein Kinases (EC 2.7.11.31) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2019-04-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 764946-0
    ISSN 1573-4935 ; 0144-8463
    ISSN (online) 1573-4935
    ISSN 0144-8463
    DOI 10.1042/BSR20181286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1676: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article: Anti-Diabetic Activities of Jiaotaiwan in db/db Mice by Augmentation of AMPK Protein Activity and Upregulation of GLUT4 Expression.

    Hu, Na / Yuan, Lin / Li, Hui-Jiao / Huang, Cheng / Mao, Quan-Ming / Zhang, Yong-Yu / Lin, Min / Sun, Yin-Qiang / Zhong, Xiao-Yu / Tang, Peng / Lu, Xiong

    Evidence-based complementary and alternative medicine : eCAM

    2013  Volume 2013, Page(s) 180721

    Abstract: Jiaotaiwan (JTW), which is composed of Coptis chinensis (CC) and cinnamon (CIN), is one of the most well-known traditional Chinese medicines. In this study, we investigated the antidiabetic effects and mechanism of JTW in db/db mice. Results showed that ... ...

    Abstract Jiaotaiwan (JTW), which is composed of Coptis chinensis (CC) and cinnamon (CIN), is one of the most well-known traditional Chinese medicines. In this study, we investigated the antidiabetic effects and mechanism of JTW in db/db mice. Results showed that JTW significantly decreased the level of fasting blood glucose and improved glucose and insulin tolerance better than CC or CIN alone. JTW also effectively protected the pancreatic islet shape, augmented the activation of AMP-activated protein kinase (AMPK) in the liver, and increased the expression of glucose transporter 4 (GLUT4) protein in skeletal muscle and white fat. AMPK and GLUT4 contributed to glucose metabolism regulation and had an essential function in the development of diabetes mellitus (DM). Therefore, the mechanisms of JTW may be related to suppressing gluconeogenesis by activating AMPK in the liver and affecting glucose uptake in surrounding tissues through the upregulation of GLUT4 protein expression. These findings provided a new insight into the antidiabetic clinical applications of JTW and demonstrated the potential of JTW as a new drug candidate for DM treatment.
    Language English
    Publishing date 2013-05-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2013/180721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Extract of Kuding tea prevents high-fat diet-induced metabolic disorders in C57BL/6 mice via liver X receptor (LXR) β antagonism.

    Fan, Shengjie / Zhang, Yu / Hu, Na / Sun, Qinhu / Ding, Xiaobo / Li, Guowen / Zheng, Bin / Gu, Ming / Huang, Feisi / Sun, Yin-Qiang / Zhou, Zhiqin / Lu, Xiong / Huang, Cheng / Ji, Guang

    PloS one

    2012  Volume 7, Issue 12, Page(s) e51007

    Abstract: Objective: To investigate the effects of ilex kudingcha C. J. Tseng (kuding tea), a traditional beverage in China, on the metabolic disorders in C57BL/6 mice induced by high-fat diets.: Design: For the preventive experiment, the female C57BL/6 mice ... ...

    Abstract Objective: To investigate the effects of ilex kudingcha C. J. Tseng (kuding tea), a traditional beverage in China, on the metabolic disorders in C57BL/6 mice induced by high-fat diets.
    Design: For the preventive experiment, the female C57BL/6 mice were fed with a standard diet (Chow), high-fat diet (HF), and high-fat diet mixed with 0.05% ethanol extract of kuding tea (EK) for 5 weeks. For the therapeutic experiment, the C57BL/6 mice were fed high-fat diet for 3 months, and then mice were split and EK was given with oral gavages for 2 weeks at 50 mg/day/kg. Body weight and daily food intake amounts were measured. At the end of treatment, the adipocyte images were assayed with a scanning electron microscope, and the fasting blood glucose, glucose tolerance test, serum lipid profile and lipids in the livers were analyzed. A reporter gene assay system was used to test the whether EK could act on nuclear receptor transcription factors, and the gene expression analysis was performed with a quantitative PCR assay.
    Results: In the preventive treatment, EK blocked the body weight gain, reduced the size of the adipocytes, lowered serum triglyceride, cholesterol, LDL-cholesterol, fasting blood glucose levels and glucose tolerance in high-fat diet-fed C57BL/6 mice. In the therapeutic treatment, EK reduced the size of the white adipocytes, serum TG and fasting blood glucose levels in obese mice. With the reporter assay, EK inhibited LXRβ transactivity and mRNA expression of LXRβ target genes.
    Conclusion: We observed that EK has both preventive and therapeutic roles in metabolic disorders in mice induced with high-fat diets. The effects appear to be mediated through the antagonism of LXRβ transactivity. Our data indicate that kuding tea is a useful dietary therapy and a potential source for the development of novel anti-obesity and lipid lowering drugs.
    MeSH term(s) 3T3-L1 Cells ; Adipocytes/cytology ; Adipocytes/drug effects ; Animals ; Cell Differentiation/drug effects ; Cell Differentiation/genetics ; Culture Media/pharmacology ; Diet, High-Fat ; Ethanol ; Female ; Gene Expression Regulation/drug effects ; Hyperlipidemias/complications ; Hyperlipidemias/drug therapy ; Hyperlipidemias/pathology ; Hyperlipidemias/prevention & control ; Ligands ; Lipogenesis/drug effects ; Lipogenesis/genetics ; Liver/drug effects ; Liver/metabolism ; Liver/pathology ; Liver X Receptors ; Metabolic Diseases/drug therapy ; Metabolic Diseases/genetics ; Metabolic Diseases/pathology ; Metabolic Diseases/prevention & control ; Mice ; Mice, Inbred C57BL ; Obesity/complications ; Obesity/drug therapy ; Obesity/pathology ; Obesity/prevention & control ; Orphan Nuclear Receptors/antagonists & inhibitors ; Orphan Nuclear Receptors/metabolism ; Phytotherapy ; Plant Extracts/pharmacology ; Plant Extracts/therapeutic use ; Tea/chemistry
    Chemical Substances Culture Media ; Ligands ; Liver X Receptors ; Orphan Nuclear Receptors ; Plant Extracts ; Tea ; Ethanol (3K9958V90M)
    Language English
    Publishing date 2012-12-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0051007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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