Artikel ; Online: Modulating TRADD to restore cellular homeostasis and inhibit apoptosis.
2020 Band 587, Heft 7832, Seite(n) 133–138
Abstract: Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathological state. Although mechanisms of cell death ... ...
Abstract | Cell death in human diseases is often a consequence of disrupted cellular homeostasis. If cell death is prevented without restoring cellular homeostasis, it may lead to a persistent dysfunctional and pathological state. Although mechanisms of cell death have been thoroughly investigated |
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Mesh-Begriff(e) | Animals ; Apoptosis/drug effects ; Autophagy/drug effects ; Baculoviral IAP Repeat-Containing 3 Protein/metabolism ; Beclin-1/chemistry ; Beclin-1/metabolism ; Bortezomib/antagonists & inhibitors ; Bortezomib/pharmacology ; Cell Line ; Homeostasis/drug effects ; Humans ; Huntingtin Protein/metabolism ; Inhibitor of Apoptosis Proteins/metabolism ; Male ; Mice ; Models, Molecular ; Neurofibrillary Tangles/metabolism ; Proteome/metabolism ; Receptor-Interacting Protein Serine-Threonine Kinases/chemistry ; Receptor-Interacting Protein Serine-Threonine Kinases/metabolism ; TNF Receptor-Associated Death Domain Protein/antagonists & inhibitors ; TNF Receptor-Associated Death Domain Protein/chemistry ; TNF Receptor-Associated Death Domain Protein/deficiency ; TNF Receptor-Associated Death Domain Protein/metabolism ; TNF Receptor-Associated Factor 2/metabolism ; Ubiquitination ; alpha-Synuclein/metabolism ; tau Proteins/metabolism |
Chemische Substanzen | Beclin-1 ; Huntingtin Protein ; Inhibitor of Apoptosis Proteins ; Proteome ; TNF Receptor-Associated Death Domain Protein ; TNF Receptor-Associated Factor 2 ; alpha-Synuclein ; tau Proteins ; Bortezomib (69G8BD63PP) ; Baculoviral IAP Repeat-Containing 3 Protein (EC 2.3.2.27) ; Receptor-Interacting Protein Serine-Threonine Kinases (EC 2.7.11.1) |
Sprache | Englisch |
Erscheinungsdatum | 2020-09-23 |
Erscheinungsland | England |
Dokumenttyp | Journal Article ; Research Support, Non-U.S. Gov't |
ZDB-ID | 120714-3 |
ISSN | 1476-4687 ; 0028-0836 |
ISSN (online) | 1476-4687 |
ISSN | 0028-0836 |
DOI | 10.1038/s41586-020-2757-z |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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