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  1. Artikel ; Online: A nano-based thermotherapy for cancer stem cell-targeted therapy.

    Suo, Xiaomin / Zhang, Juncai / Zhang, Yue / Liang, Xing-Jie / Zhang, Jinchao / Liu, Dandan

    Journal of materials chemistry. B

    2020  Band 8, Heft 18, Seite(n) 3985–4001

    Abstract: Cancer stem cells (CSCs) exhibit high resistance to conventional therapy and are responsible for cancer metastasis and tumor relapse. Therefore, it is of significance to develop effective novel strategies to target CSCs for cancer therapies. The ... ...

    Abstract Cancer stem cells (CSCs) exhibit high resistance to conventional therapy and are responsible for cancer metastasis and tumor relapse. Therefore, it is of significance to develop effective novel strategies to target CSCs for cancer therapies. The challenges associated with developing novel strategies include specific CSC targeting and overcoming their therapeutic resistance. In the present review, we summarize the various strategies for CSC-targeted cancer thermotherapy and combinational therapy, and the potential challenges and prospects for future work in this emerging field.
    Mesh-Begriff(e) Animals ; Antineoplastic Agents/chemistry ; Antineoplastic Agents/pharmacology ; Humans ; Nanomedicine ; Nanoparticles/chemistry ; Neoplastic Stem Cells/drug effects ; Particle Size ; Photothermal Therapy ; Surface Properties
    Chemische Substanzen Antineoplastic Agents
    Sprache Englisch
    Erscheinungsdatum 2020-03-31
    Erscheinungsland England
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2702241-9
    ISSN 2050-7518 ; 2050-750X
    ISSN (online) 2050-7518
    ISSN 2050-750X
    DOI 10.1039/d0tb00311e
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel ; Online: Multifunctional Magnetic Nanoplatform Eliminates Cancer Stem Cells via Inhibiting the Secretion of Extracellular Heat Shock Protein 90.

    Liu, Yajing / Suo, Xiaomin / Peng, Haotong / Yan, Weixiao / Li, Hongjuan / Yang, Xinjian / Li, Zhenhua / Zhang, Jinchao / Liu, Dandan

    Advanced healthcare materials

    2019  Band 8, Heft 13, Seite(n) e1900160

    Abstract: Cancer stem cells (CSCs) are responsible for malignant tumor initiation, recurrences, and metastasis. Therefore, targeting CSCs is a promising strategy for the development of cancer therapies. A big challenge for CSC-based cancer therapy is the ... ...

    Abstract Cancer stem cells (CSCs) are responsible for malignant tumor initiation, recurrences, and metastasis. Therefore, targeting CSCs is a promising strategy for the development of cancer therapies. A big challenge for CSC-based cancer therapy is the overexpression of therapeutic stress protein, heat shock protein 90 (Hsp90), which protects CSCs from further therapeutic-induced damage, leading to the failure of treatment. Thus, efficient strategies to target CSCs are urgently needed for cancer therapy. To this end, a multifunctional nanoparticle (MNP) for CSC-based combined thermotherapy and chemotherapy is reported. This strategy dramatically suppresses tumor growth in breast CSC xenograft-bearing mice. Furthermore, a new mechanism is present that the MNP exerts its striking effects on CSCs by inhibiting the secretion of extracellular Hsp90 (eHsp90), resulting in the interruption of several key signaling pathways. These findings open new perspectives on the use of an MNP for effective CSC-based cancer treatment by inhibiting the function of eHsp90.
    Mesh-Begriff(e) Animals ; Antibodies/chemistry ; Antibodies/immunology ; Antibodies/pharmacology ; Antibodies/therapeutic use ; Apoptosis/drug effects ; Benzoquinones/chemistry ; Benzoquinones/pharmacology ; Benzoquinones/therapeutic use ; Cell Line, Tumor ; Ferrosoferric Oxide/chemistry ; HSP90 Heat-Shock Proteins/antagonists & inhibitors ; HSP90 Heat-Shock Proteins/metabolism ; Humans ; Hyaluronan Receptors/immunology ; Hyperthermia, Induced ; Lactams, Macrocyclic/chemistry ; Lactams, Macrocyclic/pharmacology ; Lactams, Macrocyclic/therapeutic use ; Magnetite Nanoparticles/chemistry ; Mice ; Neoplasms/drug therapy ; Neoplasms/pathology ; Neoplastic Stem Cells/cytology ; Neoplastic Stem Cells/metabolism ; Porosity ; Signal Transduction/drug effects ; Silicon Dioxide/chemistry ; Transplantation, Heterologous
    Chemische Substanzen Antibodies ; Benzoquinones ; HSP90 Heat-Shock Proteins ; Hyaluronan Receptors ; Lactams, Macrocyclic ; Magnetite Nanoparticles ; 17-(dimethylaminoethylamino)-17-demethoxygeldanamycin (001L2FE0M3) ; Silicon Dioxide (7631-86-9) ; Ferrosoferric Oxide (XM0M87F357)
    Sprache Englisch
    Erscheinungsdatum 2019-04-10
    Erscheinungsland Germany
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2649576-4
    ISSN 2192-2659 ; 2192-2640
    ISSN (online) 2192-2659
    ISSN 2192-2640
    DOI 10.1002/adhm.201900160
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6966: Hefte anzeigen Standort:
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  3. Artikel ; Online: Nucleus-targeted nano delivery system eradicates cancer stem cells by combined thermotherapy and hypoxia-activated chemotherapy.

    Li, Hongjuan / Yan, Weixiao / Suo, Xiaomin / Peng, Haotong / Yang, Xinjian / Li, Zhenhua / Zhang, Jinchao / Liu, Dandan

    Biomaterials

    2019  Band 200, Seite(n) 1–14

    Abstract: Many efforts have focused on the cancer stem cell (CSC) targeting nano delivery system, however, the anticancer therapy efficacy is relative low due to the highly drug-resistance and drug efflux. Nucleus-targeted drug delivery is a promising strategy for ...

    Abstract Many efforts have focused on the cancer stem cell (CSC) targeting nano delivery system, however, the anticancer therapy efficacy is relative low due to the highly drug-resistance and drug efflux. Nucleus-targeted drug delivery is a promising strategy for reverse the drug resistance and drug efflux of CSCs, but in vivo nucleus-targeted drug delivery has been challenging. Herein, we designed a mesoporous silica nanoparticle (MSN)-based nucleus-targeted system, which could directly target the CSCs and further enter the nucleus by the surface modification of anti-CD133 and thermal-triggered exposure of TAT peptides under an alternating magnetic field (AMF). The nucleus-targeted drug release ultimately leads to an exhaustive apoptosis of the CSCs through combined thermotherapy and hypoxia-activated chemotherapy. In vivo, the nucleus-targeted nano delivery system efficiently inhibits the tumor growth without notable side effects during the course of treatment. Molecular mechanism study illustrates that the system effectively eliminates the CSCs by blocking the hypoxia signaling pathway. This designed nucleus-targeted nano delivery system is expected to provide new insights for developing efficient platforms for CSC-targeted cancer therapy.
    Mesh-Begriff(e) AC133 Antigen/metabolism ; Animals ; Antineoplastic Agents/pharmacology ; Apoptosis/drug effects ; Breast Neoplasms/metabolism ; Breast Neoplasms/pathology ; Cell Line, Tumor ; Cell Nucleus/drug effects ; Cell Nucleus/metabolism ; Cell Proliferation/drug effects ; Cell Survival/drug effects ; Drug Delivery Systems ; Drug Liberation ; Female ; Ferric Compounds/chemistry ; Humans ; Hyperthermia, Induced ; Mice, Nude ; Nanoparticles/chemistry ; Nanoparticles/ultrastructure ; Neoplastic Stem Cells/drug effects ; Neoplastic Stem Cells/metabolism ; Neoplastic Stem Cells/pathology ; Silicon Dioxide/chemistry ; Temperature ; Tissue Distribution/drug effects ; Tumor Hypoxia/drug effects
    Chemische Substanzen AC133 Antigen ; Antineoplastic Agents ; Ferric Compounds ; ferric oxide (1K09F3G675) ; Silicon Dioxide (7631-86-9)
    Sprache Englisch
    Erscheinungsdatum 2019-02-06
    Erscheinungsland Netherlands
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603079-8
    ISSN 1878-5905 ; 0142-9612
    ISSN (online) 1878-5905
    ISSN 0142-9612
    DOI 10.1016/j.biomaterials.2019.01.048
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.B 2371: Hefte anzeigen Standort:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  4. Artikel ; Online: Antioxidant properties of cap and stipe from Coprinus comatus.

    Li, Bo / Lu, Fei / Suo, Xiaomin / Nan, Haijuan / Li, Bin

    Molecules (Basel, Switzerland)

    2010  Band 15, Heft 3, Seite(n) 1473–1486

    Abstract: Coprinus comatus, also called chicken drumstick mushroom, is currently commercially available in China. Hot water and ethanolic extracts were prepared from cap and stipe of C. comatus fruit bodies and their antioxidant properties were studied. Ethanolic ... ...

    Abstract Coprinus comatus, also called chicken drumstick mushroom, is currently commercially available in China. Hot water and ethanolic extracts were prepared from cap and stipe of C. comatus fruit bodies and their antioxidant properties were studied. Ethanolic extract from stipe showed high antioxidant activity (80.6%) at 1 mg/mL. Reducing power of hot water extracts from cap was 1.653 at 10 mg/mL. Extracts from cap showed better scavenging ability on DPPH (57.9% at 1 mg/mL) than stipe ones. Ethanolic extracts were more effective in scavenging ability on hydroxyl radicals (57.4-61.3% at 5 mg/mL) than hot water extracts. Ethanolic extracts showed moderate scavenging ability on superoxide radicals (46.3-47.0% at 20 mg/mL). Naturally occurring antioxidant components including total phenols (3.60-20.00 mg/g), tocopherols (0.58-11.93 mg/g), flavonoids (0.19-3.52 mg/g) and polysaccharides (58.52-547.86 mg/g) were found in the extracts. Overall, extracts from cap were more effective for the antioxidant properties assayed.
    Mesh-Begriff(e) Antioxidants/pharmacology ; Chromatography, High Pressure Liquid ; Coprinus/chemistry ; Free Radicals/chemistry ; Plant Extracts/pharmacology ; Spectrophotometry, Ultraviolet
    Chemische Substanzen Antioxidants ; Free Radicals ; Plant Extracts
    Sprache Englisch
    Erscheinungsdatum 2010-03-09
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules15031473
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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    Verfügbar in ZB MED Köln/Königswinter

    Zs.MO 81: Hefte anzeigen

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  5. Artikel ; Online: Y

    Gao, Chunyue / Jin, Yi / Jia, Guang / Suo, Xiaomin / Liu, Huifang / Liu, Dandan / Yang, Xinjian / Ge, Kun / Liang, Xing-Jie / Wang, Shuxiang / Zhang, Jinchao

    ACS nano

    2018  Band 13, Heft 1, Seite(n) 313–323

    Abstract: ... ...

    Abstract Y
    Mesh-Begriff(e) Animals ; Apoptosis ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/metabolism ; Cathepsins/metabolism ; Cells, Cultured ; Female ; Lysosomes/drug effects ; Lysosomes/metabolism ; Mice ; Mice, Inbred ICR ; Mitochondria/genetics ; Mitochondria/metabolism ; Nanoparticles/chemistry ; Nanoparticles/toxicity ; Phosphates/metabolism ; Yttrium/chemistry ; Yttrium/pharmacokinetics ; Yttrium/toxicity
    Chemische Substanzen Phosphates ; Yttrium (58784XQC3Y) ; Cathepsins (EC 3.4.-) ; yttria (X8071685XT)
    Sprache Englisch
    Erscheinungsdatum 2018-12-24
    Erscheinungsland United States
    Dokumenttyp Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1936-086X
    ISSN (online) 1936-086X
    DOI 10.1021/acsnano.8b06211
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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