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  1. Artikel ; Online: De novo exon 18 G724S point mutation may be sensitive to Gefitinib

    Tai‐Huang Lee / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 37, Iss 10, Pp 918-

    2021  Band 919

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2021-10-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  2. Artikel ; Online: EGFR‐TKI plus antiangiogenic agent combination therapy may reduce the incidence of EGFR‐TKI–associated interstitial lung disease in Asian

    Tai‐Huang Lee / Hsiao‐Ling Chen / Ming‐Ju Tsai / Chih‐Jen Yang

    Kaohsiung Journal of Medical Sciences, Vol 38, Iss 11, Pp 1133-

    2022  Band 1134

    Schlagwörter Medicine (General) ; R5-920
    Sprache Englisch
    Erscheinungsdatum 2022-11-01T00:00:00Z
    Verlag Wiley
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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  3. Artikel ; Online: First-Line Anaplastic Lymphoma Kinase (ALK) Inhibitors for ALK-Positive Lung Cancer in Asian Populations

    Kuan-Li Wu / Hsiao-Ling Chen / Ying-Ming Tsai / Tai-Huang Lee / Hsiu-Mei Chang / Yu-Chen Tsai / Cheng-Hao Chuang / Yong-Chieh Chang / Yu-Kang Tu / Chih-Jen Yang / Jen-Yu Hung / Inn-Wen Chong

    Journal of Clinical Medicine, Vol 10, Iss 4376, p

    Systematic Review and Network Meta-Analysis

    2021  Band 4376

    Abstract: Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs ... ...

    Abstract Various anaplastic lymphoma kinase inhibitors (ALKIs) have been approved for first-line use in treating anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC). To date, no head-to-head comparison of these newer generation ALKIs has been made, and different efficacies of ALKIs may present across ethnicity. This study aims to compare newer generation ALKIs for treatment efficacy in Asian groups using network meta-analysis. Phase II/III trials that enrolled treatment-naïve Asian ALK-rearranged NSCLC patients treated by ALKIs were included. Progression-free survival (PFS) and overall response rate (ORR) of each trial were extracted as indicators of drug efficacy. Surfaces under cumulative ranking curves (SUCRAs) were calculated as a numeric presentation of the overall ranking associated with each agent. After a systematic literature review, six phase III clinical trials were included. Our results showed that newer generation ALKIs, such as alectinib, brigatinib, ensartinib, and lorlatinib, all demonstrated superior efficacy to crizotinib. Among those, ensartinib exhibited the best overall SUCRA value and ranked first among all agents. According to our network meta-analysis, ensartinib may currently be the most effective first-line treatment for Asian patients with ALK-positive NSCLC. However, this conclusion needs further validation by a larger scale of clinical trials or posthoc analysis of Asian populations. Moreover, in our comparison, low-dose alectinib (300 mg twice daily) exhibited an efficacy profile similar to a higher dose regimen in Asian populations.
    Schlagwörter Asian ; anaplastic lymphoma kinase inhibitor ; non-small cell lung cancer ; Medicine ; R
    Thema/Rubrik (Code) 610
    Sprache Englisch
    Erscheinungsdatum 2021-09-01T00:00:00Z
    Verlag MDPI AG
    Dokumenttyp Artikel ; Online
    Datenquelle BASE - Bielefeld Academic Search Engine (Lebenswissenschaftliche Auswahl)

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