Artikel ; Online: γδ T cells in oral diseases.
Inflammation research : official journal of the European Histamine Research Society ... [et al.
2024 Band 73, Heft 5, Seite(n) 867–876
Abstract: Objective: γδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting with other immune cells, thereby modulating immune responses. As the first line of host defense, γδ T ... ...
Abstract | Objective: γδ T cells are a distinct subset of unconventional T cells, which link innate and adaptive immunity by secreting cytokines and interacting with other immune cells, thereby modulating immune responses. As the first line of host defense, γδ T cells are essential for mucosal homeostasis and immune surveillance. When abnormally activated or impaired, γδ T cells can contribute to pathogenic processes. Accumulating evidence has revealed substantial impacts of γδ T cells on the pathogenesis of cancers, infections, and immune-inflammatory diseases. γδ T cells exhibit dual roles in cancers, promoting or inhibiting tumor growth, depending on their phenotypes and the clinical stage of cancers. During infections, γδ T cells exert high cytotoxic activity in infectious diseases, which is essential for combating bacterial and viral infections by recognizing foreign antigens and activating other immune cells. γδ T cells are also implicated in the onset and progression of immune-inflammatory diseases. However, the specific involvement and underlying mechanisms of γδ T cells in oral diseases have not been systematically discussed. Methods: We conducted a systematic literature review using the PubMed/MEDLINE databases to identify and analyze relevant literature on the roles of γδ T cells in oral diseases. Results: The literature review revealed that γδ T cells play a pivotal role in maintaining oral mucosal homeostasis and are involved in the pathogenesis of oral cancers, periodontal diseases, graft-versus-host disease (GVHD), oral lichen planus (OLP), and oral candidiasis. γδ T cells mainly influence various pathophysiological processes, such as anti-tumor activity, eradication of infection, and immune response regulation. Conclusion: This review focuses on the involvement of γδ T cells in oral diseases, with a particular emphasis on the main functions and underlying mechanisms by which γδ T cells influence the pathogenesis and progression of these conditions. This review underscores the potential of γδ T cells as therapeutic targets in managing oral health issues. |
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Mesh-Begriff(e) | Humans ; Mouth Diseases/immunology ; Animals ; Receptors, Antigen, T-Cell, gamma-delta/immunology ; Receptors, Antigen, T-Cell, gamma-delta/metabolism ; Intraepithelial Lymphocytes/immunology ; Graft vs Host Disease/immunology ; T-Lymphocytes/immunology |
Chemische Substanzen | Receptors, Antigen, T-Cell, gamma-delta |
Sprache | Englisch |
Erscheinungsdatum | 2024-04-02 |
Erscheinungsland | Switzerland |
Dokumenttyp | Journal Article ; Systematic Review ; Review |
ZDB-ID | 1221794-3 |
ISSN | 1420-908X ; 1023-3830 |
ISSN (online) | 1420-908X |
ISSN | 1023-3830 |
DOI | 10.1007/s00011-024-01870-z |
Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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