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  1. Artikel ; Online: Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis

    Liu, Yang / Tang, Amei / Liu, Ming / Xu, Changjun / Cao, Feng / Yang, Changfu

    Journal of Ethnopharmacology. 2024 Jan., v. 318 p.116983-

    2024  

    Abstract: Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona sessilifolia (Miq.) Miq. or Stemona ... ...

    Abstract Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona sessilifolia (Miq.) Miq. or Stemona japonica (Blume) Miq. (The plant name has been checked with http://www.theplantlist.org), of which multiple biological activities has been verified. However, whether it may alleviate pulmonary fibrosis via regulating ferroptosis mechanism has not been confirmed. The aim of this study is to observe whether tuberostemonine alleviates pulmonary fibrosis by enhancing the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis. We validated the effects of tuberostemonine and ferroptosis on TGF-β1-induced proliferation of human lung fibroblast and bleomycin-induced pulmonary fibrosis in mice. In vitro, the ferroptosis effect of TGF-β1 on human lung fibroblast were examined and the activity of ɑ-SMA, collagen, hydroxyproline and ferrous ions in cells were also examined. In vivo, ferroptosis impacts respiratory function. Inflammatory manifestations, hydroxyproline, collagen activity and ferrous ions in the lung or blood were subject to evaluation. Tuberostemonine significantly improved respiratory function in mice with bleomycin-induced pulmonary fibrosis, decreased cellular and lung hydroxyproline content, reduced inflammation and collagen deposition in cells and lung, and promoted an increase in the SLC7A11 and GPX4 proteins. Tuberostemonine inhibits the ferroptosis phenomenon, up-regulates SLC7A11, GPX4 and GSH, and down-regulates the accumulation of iron and ROS. Tuberostemonine significantly inhibited ferroptosis and improved pulmonary fibrosis both in vivo and vitro.
    Schlagwörter Stemona sessilifolia ; Stemona tuberosa ; antiporters ; blood ; collagen ; cough ; ferroptosis ; fibroblasts ; humans ; hydroxyproline ; inflammation ; iron ; lung function ; lungs ; medicinal plants ; pulmonary fibrosis ; traditional medicine ; tuberculosis ; China ; Tuberostemonine ; Respiratory diseases
    Sprache Englisch
    Erscheinungsverlauf 2024-01
    Erscheinungsort Elsevier B.V.
    Dokumenttyp Artikel ; Online
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116983
    Datenquelle NAL Katalog (AGRICOLA)

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  2. Artikel: Non-linear association of cystatin C and all-cause mortality of heart failure: A secondary analysis based on a published database.

    Zheng, Tao / Tang, A-Mei / Huang, Yuan-Lei / Chen, Jin

    Frontiers in cardiovascular medicine

    2022  Band 9, Seite(n) 930498

    Abstract: Background: Prior reports have revealed that basal Cystatin-C (CysC) is positively associated with all-cause death in patients with heart failure (HF). Yet, this positive association is not necessarily generalizable to Chinese HF patients due to ... ...

    Abstract Background: Prior reports have revealed that basal Cystatin-C (CysC) is positively associated with all-cause death in patients with heart failure (HF). Yet, this positive association is not necessarily generalizable to Chinese HF patients due to methodological limitations and lack of data from Chinese patients.
    Materials and methods: We performed secondary data mining based on a retrospective cohort dataset published on the internet. This dataset contains 2008 patients with HF who were admitted to a tertiary hospital in Sichuan Province, China from 2016 to 2019. The exposure variable was baseline CysC and the outcome variable was all-cause death on day 28, day 90, and month 6. Covariates were baseline measurements, including demographic data, drug use, comorbidity score, organ function status (heart, kidney), and severity of heart failure.
    Results: Among 1966 selected participants, the mortality rates at 28 days, 90 days and 6 months were 1.83% (36/1966), 2.09% (41/1966) and 2.85% (56/1966) respectively. After adjustment for confounders, the non-linear associations between CysC and all-cause deaths were observed. We calculated the inflection points were about 2.5 mg/L of CysC. On the right of inflection point, each increase of 1 mg/L in CysC was associated with an increase in the risk of 28-day mortality (Relative risk [RR], 2.07; 95% confidence interval [CI], 1.09 to 3.93;
    Conclusion: Our findings suggest that values about 2.5 mg/l of cystatin could be a danger threshold for the short-term risk of death in heart failure. Exceeding this threshold, for every 1 mg/L increase in CysC, the risk of all-cause mortality increased by more than one time.
    Sprache Englisch
    Erscheinungsdatum 2022-09-06
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.930498
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  3. Artikel ; Online: Tuberostemonine may enhance the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis to alleviate pulmonary fibrosis.

    Liu, Yang / Tang, Amei / Liu, Ming / Xu, Changjun / Cao, Feng / Yang, Changfu

    Journal of ethnopharmacology

    2023  Band 318, Heft Pt B, Seite(n) 116983

    Abstract: Ethnopharmacological relevance: Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona ... ...

    Abstract Ethnopharmacological relevance: Stemona is a medicinal plant that has been used in China for thousands of years to treat respiratory diseases such as cough and tuberculosis. The tuberostemonine is the component of the Stemona tuberosa Lour., Stemona sessilifolia (Miq.) Miq. or Stemona japonica (Blume) Miq. (The plant name has been checked with http://www.theplantlist.org), of which multiple biological activities has been verified. However, whether it may alleviate pulmonary fibrosis via regulating ferroptosis mechanism has not been confirmed.
    Aim of the study: The aim of this study is to observe whether tuberostemonine alleviates pulmonary fibrosis by enhancing the function of the SLC7A11/glutamate antiporter to restrain the ferroptosis.
    Materials and methods: We validated the effects of tuberostemonine and ferroptosis on TGF-β1-induced proliferation of human lung fibroblast and bleomycin-induced pulmonary fibrosis in mice. In vitro, the ferroptosis effect of TGF-β1 on human lung fibroblast were examined and the activity of ɑ-SMA, collagen, hydroxyproline and ferrous ions in cells were also examined. In vivo, ferroptosis impacts respiratory function. Inflammatory manifestations, hydroxyproline, collagen activity and ferrous ions in the lung or blood were subject to evaluation.
    Results: Tuberostemonine significantly improved respiratory function in mice with bleomycin-induced pulmonary fibrosis, decreased cellular and lung hydroxyproline content, reduced inflammation and collagen deposition in cells and lung, and promoted an increase in the SLC7A11 and GPX4 proteins. Tuberostemonine inhibits the ferroptosis phenomenon, up-regulates SLC7A11, GPX4 and GSH, and down-regulates the accumulation of iron and ROS.
    Conclusions: Tuberostemonine significantly inhibited ferroptosis and improved pulmonary fibrosis both in vivo and vitro.
    Mesh-Begriff(e) Mice ; Humans ; Animals ; Pulmonary Fibrosis/chemically induced ; Pulmonary Fibrosis/drug therapy ; Pulmonary Fibrosis/metabolism ; Transforming Growth Factor beta1/metabolism ; Glutamic Acid ; Hydroxyproline ; Ferroptosis ; Collagen/metabolism ; Bleomycin ; Ions/adverse effects ; Ions/metabolism ; Amino Acid Transport System y+
    Chemische Substanzen tuberostemonine (6879-01-2) ; Transforming Growth Factor beta1 ; Glutamic Acid (3KX376GY7L) ; Hydroxyproline (RMB44WO89X) ; Collagen (9007-34-5) ; Bleomycin (11056-06-7) ; Ions ; SLC7A11 protein, human ; Amino Acid Transport System y+
    Sprache Englisch
    Erscheinungsdatum 2023-08-01
    Erscheinungsland Ireland
    Dokumenttyp Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116983
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  4. Artikel ; Online: Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococci Recovered from Public Shared Bicycles in China.

    Xu, Zhen / Chen, Liqin / Chen, Xiaowei / Tang, Amei / Huang, Dengmin / Pan, Qin / Fang, Zhongze

    International journal of environmental research and public health

    2022  Band 19, Heft 8

    Abstract: Millions of public shared bicycles (PSBs) have been launched in China, and PSBs are a potential reservoir of antimicrobial-resistant staphylococci. However, no national data to elucidate the dissemination, antimicrobial resistance and genotypes of ... ...

    Abstract Millions of public shared bicycles (PSBs) have been launched in China, and PSBs are a potential reservoir of antimicrobial-resistant staphylococci. However, no national data to elucidate the dissemination, antimicrobial resistance and genotypes of staphylococci has been recovered from public shared bicycles located in different cities in China. Antimicrobial susceptibility, SCC
    Mesh-Begriff(e) Anti-Bacterial Agents/pharmacology ; Humans ; Methicillin Resistance/genetics ; Methicillin-Resistant Staphylococcus aureus/genetics ; Microbial Sensitivity Tests ; Prevalence ; Staphylococcal Infections/epidemiology ; Staphylococcus/genetics ; Staphylococcus epidermidis/genetics
    Chemische Substanzen Anti-Bacterial Agents
    Sprache Englisch
    Erscheinungsdatum 2022-04-08
    Erscheinungsland Switzerland
    Dokumenttyp Journal Article
    ZDB-ID 2175195-X
    ISSN 1660-4601 ; 1661-7827
    ISSN (online) 1660-4601
    ISSN 1661-7827
    DOI 10.3390/ijerph19084492
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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