Artikel ; Online: Molecular pathways of NF-ĸB and NLRP3 inflammasome as potential targets in the treatment of inflammation in diabetic wounds: A review.
2023 Band 334, Seite(n) 122228
Abstract: Diabetic wounds are slow healing wounds characterized by disordered healing processes and frequently take longer than three months to heal. One of the defining characteristics of impaired diabetic wound healing is an abnormal and unresolved inflammatory ... ...
| Abstract | Diabetic wounds are slow healing wounds characterized by disordered healing processes and frequently take longer than three months to heal. One of the defining characteristics of impaired diabetic wound healing is an abnormal and unresolved inflammatory response, which is primarily brought on by abnormal macrophage innate immune signaling activation. The persistent inflammatory state in a diabetic wound may be attributed to inflammatory pathways such as nuclear factor kappa B (NF-ĸB) and nod-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome, which have long been associated with inflammatory diseases. Despite the available treatments for diabetic foot ulcers (DFUs) that include debridement, growth factor therapy, and topical anti-bacterial agents, successful wound healing is still hampered. Further understanding of the molecular mechanism of these pathways could be useful in designing potential therapeutic targets for diabetic wound healing. This review provides an update and novel insights into the roles of NF-ĸB and NLRP3 pathways in the molecular mechanism of diabetic wound inflammation and their potential as therapeutic targets in diabetic wound healing. |
|---|---|
| Mesh-Begriff(e) | Humans ; Diabetes Mellitus ; Diabetic Foot/drug therapy ; Inflammasomes/metabolism ; Inflammation/drug therapy ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism |
| Chemische Substanzen | Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; NLRP3 protein, human |
| Sprache | Englisch |
| Erscheinungsdatum | 2023-11-01 |
| Erscheinungsland | Netherlands |
| Dokumenttyp | Journal Article ; Review |
| ZDB-ID | 3378-9 |
| ISSN | 1879-0631 ; 0024-3205 |
| ISSN (online) | 1879-0631 |
| ISSN | 0024-3205 |
| DOI | 10.1016/j.lfs.2023.122228 |
| Datenquelle | MEDical Literature Analysis and Retrieval System OnLINE |
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