Article ; Online: Functions of DEAD box RNA helicases DDX5 and DDX17 in chromatin organization and transcriptional regulation.
2018 Volume 51, Issue 12, Page(s) 613–622
Abstract: RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing ... ...
Abstract | RNA helicases DDX5 and DDX17 are multitasking proteins that regulate gene expression in different biological contexts through diverse activities. Special attention has long been paid to their function as coregulators of transcription factors, providing insight about their functional association with a number of chromatin modifiers and remodelers. However, to date, the variety of described mechanisms has made it difficult to understand precisely how these proteins work at the molecular level, and the contribution of their ATPase domain to these mechanisms remains unclear as well. In light of their association with long noncoding RNAs that are key epigenetic regulators, an emerging view is that DDX5 and DDX17 may act through modulating the activity of various ribonucleoprotein complexes that could ensure their targeting to specific chromatin loci. This review will comprehensively describe the current knowledge on these different mechanisms. We will also discuss the potential roles of DDX5 and DDX17 on the 3D chromatin organization and how these could impact gene expression at the transcriptional and post-transcriptional levels. [BMB Reports 2018; 51(12): 613-622]. |
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MeSH term(s) | Animals ; Chromatin/metabolism ; Chromatin Assembly and Disassembly ; DEAD-box RNA Helicases/chemistry ; DEAD-box RNA Helicases/metabolism ; Humans ; Protein Processing, Post-Translational ; RNA, Untranslated/chemistry ; RNA, Untranslated/metabolism ; Transcription Factors/genetics ; Transcription Factors/metabolism ; Transcription, Genetic |
Chemical Substances | Chromatin ; RNA, Untranslated ; Transcription Factors ; DDX17 protein, human (EC 3.6.1.-) ; Ddx5 protein, human (EC 3.6.1.-) ; DEAD-box RNA Helicases (EC 3.6.4.13) |
Language | English |
Publishing date | 2018-10-08 |
Publishing country | Korea (South) |
Document type | Journal Article ; Review |
ZDB-ID | 2410389-5 |
ISSN | 1976-670X ; 1976-6696 |
ISSN (online) | 1976-670X |
ISSN | 1976-6696 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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