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  1. Artikel ; Online: Processing speed predicts SuperAging years later.

    Ticha, Zuzana / Georgi, Hana / Schmand, Ben / Heissler, Radek / Kopecek, Miloslav

    BMC psychology

    2023  Band 11, Heft 1, Seite(n) 34

    Abstract: Background: SuperAging is one of the current concepts related to elite, resilient or high-functioning cognitive aging. The main aim of our study was to find possible predictors of SuperAgers (SA).: Methods: Community-dwelling older persons (N = 96) ... ...

    Abstract Background: SuperAging is one of the current concepts related to elite, resilient or high-functioning cognitive aging. The main aim of our study was to find possible predictors of SuperAgers (SA).
    Methods: Community-dwelling older persons (N = 96) aged 80-101 years in 2018 were repeatedly tested (year 2012 and 2018). SA were defined based on their performance in 2018 as persons of 80+ years of age who recalled ≥ 9 words in the delayed recall of the Philadelphia Verbal Learning Test, and had a normal performance in non-memory tasks [the Boston Naming Test, the Trail Making Test Part B, and Category Fluency ("Animals")], which was defined as a score within or above one standard deviation from the age and education appropriate average. Three composite scores (CS; immediate memory, processing speed, and executive functions) were created from the performance in 2012, and analysed as possible predictors of SA status in 2018.
    Results: We identified 19 SA (15 females) and 77 nonSA (42 females), groups did not significantly differ in age, years of education, and sex. The logistic regression model (p = 0.028) revealed three predictors of SA from the baseline (year 2012), including processing speed (p = 0.006; CS-speed: the Prague Stroop Test-Dots and the Digit Symbol Substitution Test), sex (p = 0.015), and age (p = 0.045).
    Conclusions: Thus, SA may be predicted based on the level of processing speed, which supports the hypothesis of the processing speed theory of healthy aging.
    Mesh-Begriff(e) Female ; Humans ; Neuropsychological Tests ; Processing Speed ; Cognition Disorders/psychology ; Executive Function ; Stroop Test ; Cognition
    Sprache Englisch
    Erscheinungsdatum 2023-02-02
    Erscheinungsland England
    Dokumenttyp Journal Article
    ZDB-ID 2705921-2
    ISSN 2050-7283 ; 2050-7283
    ISSN (online) 2050-7283
    ISSN 2050-7283
    DOI 10.1186/s40359-023-01069-7
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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  2. Artikel: Proteomic analysis of MOLT-4 cells treated by valproic acid

    Vávrová, Jiřina / Janovská, Sylva / Řezáčová, Martina / Hernychová, Lenka / Tichá, Zuzana / Vokurková, Doris / Záškodová, Darina / Lukášová, Emilie

    Molecular and cellular biochemistry. 2007 Sept., v. 303, no. 1-2

    2007  

    Abstract: The effect of valproic acid (VA) on protein expression in human T-lymphocytic leukemia cells MOLT-4 was studied. VA is an inhibitor of histonedeacetylases and has a potential use as antitumor agent in leukemia treatment. The authors in this work prove ... ...

    Abstract The effect of valproic acid (VA) on protein expression in human T-lymphocytic leukemia cells MOLT-4 was studied. VA is an inhibitor of histonedeacetylases and has a potential use as antitumor agent in leukemia treatment. The authors in this work prove that 4 h long incubation with 2 mmol/l VA causes phosphorylation of histone H2A.X and its colocalization with 53BP1 in nuclear foci. Their co-localization is typical for DSB signaling machinery. These foci were detected in cells after 4 h exposure without increase of Annexin V positive apoptotic cells. Slight increase in apoptosis (Annexin V positivity) after 24 h is accompanied by more intensive increase in phosphorylation of H2A.X and also by formation of nuclear foci containing γH2A.X and 53BP1. Treatment of cells with 2 mmol/l VA resulted in induction of apoptosis affecting about 30% of cells after incubation for 72 h. The changes in protein expression were examined after cell incubation with 2 mmol/l VA for 4 h. Proteins were separated by two-dimensional electrophoresis and quantified using image evaluation system. Those exhibiting significant VA-induced abundance alterations were identified by mass spectrometry. Changes in expression of 22 proteins were detected, of which 15 proteins were down-regulated. Proteomic analysis resulted in successful identification of three proteins involving alfa-tubulin 3, tubulin-specific chaperone and heterogeneous nuclear ribonucloprotein F. Expression of seven proteins was up-regulated, including heterogeneous nuclear ribonucloprotein A/B. Identified proteins are related to microtubular system and hnRNP family. Suppression of microtubular proteins and changes of balance among hnRNPs can contribute to proliferation arrest and apoptosis induction.
    Schlagwörter valproic acid
    Sprache Englisch
    Erscheinungsverlauf 2007-09
    Umfang p. 53-61.
    Verlag Springer US
    Erscheinungsort Boston
    Dokumenttyp Artikel
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-007-9455-0
    Datenquelle NAL Katalog (AGRICOLA)

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    Verfügbar in ZB MED Bonn

    Z 74/721: Hefte anzeigen

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  3. Artikel: Proteomic analysis of MOLT-4 cells treated by valproic acid.

    Vávrová, Jirina / Janovská, Sylva / Rezácová, Martina / Hernychová, Lenka / Tichá, Zuzana / Vokurková, Doris / Záskodová, Darina / Lukásová, Emilie

    Molecular and cellular biochemistry

    2007  Band 303, Heft 1-2, Seite(n) 53–61

    Abstract: The effect of valproic acid (VA) on protein expression in human T-lymphocytic leukemia cells MOLT-4 was studied. VA is an inhibitor of histonedeacetylases and has a potential use as antitumor agent in leukemia treatment. The authors in this work prove ... ...

    Abstract The effect of valproic acid (VA) on protein expression in human T-lymphocytic leukemia cells MOLT-4 was studied. VA is an inhibitor of histonedeacetylases and has a potential use as antitumor agent in leukemia treatment. The authors in this work prove that 4 h long incubation with 2 mmol/l VA causes phosphorylation of histone H2A.X and its colocalization with 53BP1 in nuclear foci. Their co-localization is typical for DSB signaling machinery. These foci were detected in cells after 4 h exposure without increase of Annexin V positive apoptotic cells. Slight increase in apoptosis (Annexin V positivity) after 24 h is accompanied by more intensive increase in phosphorylation of H2A.X and also by formation of nuclear foci containing gammaH2A.X and 53BP1. Treatment of cells with 2 mmol/l VA resulted in induction of apoptosis affecting about 30% of cells after incubation for 72 h. The changes in protein expression were examined after cell incubation with 2 mmol/l VA for 4 h. Proteins were separated by two-dimensional electrophoresis and quantified using image evaluation system. Those exhibiting significant VA-induced abundance alterations were identified by mass spectrometry. Changes in expression of 22 proteins were detected, of which 15 proteins were down-regulated. Proteomic analysis resulted in successful identification of three proteins involving alfa-tubulin 3, tubulin-specific chaperone and heterogeneous nuclear ribonucloprotein F. Expression of seven proteins was up-regulated, including heterogeneous nuclear ribonucloprotein A/B. Identified proteins are related to microtubular system and hnRNP family. Suppression of microtubular proteins and changes of balance among hnRNPs can contribute to proliferation arrest and apoptosis induction.
    Mesh-Begriff(e) Annexin A5/metabolism ; Apoptosis/drug effects ; Cell Survival/drug effects ; Electrophoresis, Gel, Two-Dimensional ; Enzyme Inhibitors/pharmacology ; Flow Cytometry ; Heterogeneous-Nuclear Ribonucleoproteins/metabolism ; Histone Deacetylase Inhibitors ; Humans ; Leukemia, T-Cell/drug therapy ; Leukemia, T-Cell/metabolism ; Leukemia, T-Cell/pathology ; Neoplasm Proteins/metabolism ; Proteome/analysis ; Signal Transduction ; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization ; Valproic Acid/pharmacology
    Chemische Substanzen Annexin A5 ; Enzyme Inhibitors ; Heterogeneous-Nuclear Ribonucleoproteins ; Histone Deacetylase Inhibitors ; Neoplasm Proteins ; Proteome ; Valproic Acid (614OI1Z5WI)
    Sprache Englisch
    Erscheinungsdatum 2007-09
    Erscheinungsland Netherlands
    Dokumenttyp Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 184833-1
    ISSN 1573-4919 ; 0300-8177
    ISSN (online) 1573-4919
    ISSN 0300-8177
    DOI 10.1007/s11010-007-9455-0
    Datenquelle MEDical Literature Analysis and Retrieval System OnLINE

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