Artikel: Characterization and antioxidant activities of the polysaccharides from Radix Cyathulae officinalis Kuan
International journal of biological macromolecules. 2015 Jan., v. 72
2015
Abstract: A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular ... ...
| Abstract | A water-soluble polysaccharide (PSRC) was extracted and purified from the roots of Radix Cyathulae officinalis Kuan, and its chemical characteristics, monosaccharide composition and antioxidant activities were characterized. The average of molecular weight (Mw) of PSRC was 182kDa. The majority of monosaccharide components of PSRC was glucose (relative mass 48.8%) with lower levels of mannose, rhamnose, galactose, fructose and arabinose (relative mass of 15.7, 14.3, 10.6, 6.1 and 4.5%, respectively). In vitro assays revealed that RSRC possessed potent scavenging activities against DPPH, hydroxyl and superoxide anion radicals. Oral administration of PSRC significantly enhanced antioxidant enzyme activities (including total superoxide dismutase, copper-zinc superoxide dismutase (Cu,Zn-SOD), manganese superoxide dismutase (Mn-SOD), glutathione peroxidase and catalase (CAT)) and capacities of scavenging superoxide anion and hydroxyl radicals, markedly lowered lipid peroxidation formation of malondialdehyde and significantly up-regulated mRNA expressions of Cu,Zn-SOD, Mn-SOD, CAT, glutathione peroxidase 1, thioredoxin 1 and thioredoxin 2, in a d-galactose-induced aging mouse model. Taken together, these findings demonstrate that PSRC could be used as a novel promising source of natural antioxidants and antiaging drugs. |
|||||
|---|---|---|---|---|---|---|
| Schlagwörter | 2,2-diphenyl-1-picrylhydrazyl ; animal models ; antioxidant activity ; antioxidants ; arabinose ; catalase ; drugs ; enzyme activity ; fructose ; galactose ; gene expression regulation ; glucose ; glutathione peroxidase ; hydroxyl radicals ; in vitro studies ; lipid peroxidation ; malondialdehyde ; mannose ; messenger RNA ; molecular weight ; oral administration ; polysaccharides ; rhamnose ; roots ; superoxide anion ; superoxide dismutase | |||||
| Sprache | Englisch | |||||
| Erscheinungsverlauf | 2015-01 | |||||
| Umfang | p. 544-552. | |||||
| Erscheinungsort | Elsevier B.V. | |||||
| Dokumenttyp | Artikel | |||||
| ZDB-ID | 282732-3 | |||||
| ISSN | 1879-0003 ; 0141-8130 | |||||
| ISSN (online) | 1879-0003 | |||||
| ISSN | 0141-8130 | |||||
| DOI | 10.1016/j.ijbiomac.2014.09.007 | |||||
| Signatur |
|
|||||
| Datenquelle | NAL Katalog (AGRICOLA) |
Volltext online
Zusatzmaterialien
Kategorien
Verfügbar in ZB MED Köln/Königswinter
| Zs.B 2374: Hefte anzeigen | Standort: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG) |
Über subito bestellen
Dieser Service ist kostenpflichtig (siehe Lieferbedingungen von subito). Bestellungen, die einen Artikel nebst Supplementary Material umfassen, werden grundsätzlich wie mehrfache Bestellungen bearbeitet. Gebühren fallen in diesen Fällen für jede einzelne Bestellung an.